Expandable foam-like biomaterials and methods
First Claim
1. A proteinaceous biopolymeric material having a cellular foam structure.
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Accused Products
Abstract
Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
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Citations
40 Claims
- 1. A proteinaceous biopolymeric material having a cellular foam structure.
- 2. A biopolymeric material which is the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant in amounts sufficient to impart a cellular foam structure to the material.
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12. A method of making a biopolymeric material having a cellular foam structure comprising introducing a blowing agent into a proteinaceous cross-linkable pre-polymeric liquid material, and allowing the liquid material to cross-link simultaneously with evolution of gas from said blowing agent to thereby form the biopolymeric material having a cellular foam structure.
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18. A method of making a biopolymeric material having a cellular foam structure comprising introducing a gaseous blowing agent into a proteinaceous pre-polymeric liquid material, and allowing the liquid material to solidify to thereby form the biopolymeric material having a cellular foam structure.
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19. A method of treating a tissue site, which comprises applying to the tissue site a proteinaceous pre-polymeric liquid material containing a gaseous blowing agent, and allowing the liquid material to solidify to thereby form the biopolymeric material having a cellular foam structure.
- 30. A kit for forming a proteinaceous biopolymeric material comprising separate reactable aliquot portions of a first aqueous solution containing a proteinaceous material, and a second aqueous solution which is reactable with the proteinaceous component of the first aqueous solution to form a proteinaceous biopolymeric material, and wherein the first aqueous solution includes a blowing agent, and wherein said second aqueous solution includes an acidic titrant reactable on contact with the blowing agent sufficient to evolve a gas to impart a cellular foam structure to the proteinaceous biopolymeric material.
Specification