Method for optimally delivering virus to a solid tumor mass
First Claim
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1. A method for delivering a virus to a solid tumor to reduce growth of the tumor, comprising administering an effective amount of virus to a subject bearing the tumor, wherein the virus is capable of selectively killing tumor cells, by a base administration selected from the group consisting of:
- (a) delivering a composition comprising the virus to multiple sites inside the solid tumor; and
(b) delivering directly into the tumor a composition comprising the virus, wherein the volume of the composition is between about 10% to about 100% of the volume of the tumor.
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Abstract
This invention relates to a method for optimally delivering virus to a solid tumor. Two approaches can be adopted to increase the number of tumor cells inside the solid tumor which are exposed to virus. The virus can be delivered to multiple sites inside the solid tumor, or the virus can be delivered to a single site in such a large volume that the delivered virus is capable of reaching more tumor cells in the solid tumor.
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21 Claims
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1. A method for delivering a virus to a solid tumor to reduce growth of the tumor, comprising administering an effective amount of virus to a subject bearing the tumor, wherein the virus is capable of selectively killing tumor cells, by a base administration selected from the group consisting of:
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(a) delivering a composition comprising the virus to multiple sites inside the solid tumor; and
(b) delivering directly into the tumor a composition comprising the virus, wherein the volume of the composition is between about 10% to about 100% of the volume of the tumor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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