Method and apparatus for high-resolution detection and characterization of medical pathologies

• US 20020065466A1
• Filed: 11/27/2001
• Published: 05/30/2002
• Est. Priority Date: 03/20/1998
• Status: Active Grant

• Current Assignee: Delphinus Medical Technologies, Inc.
• Original Assignee: Barbara Ann Karmanos Cancer Institute
• Inventors: Rather, John D. G., Zeiders, Glenn W., Doolittle, Richard D., Littrup, Peter J., Caulfield, H. John
• Granted Patent: US 6,728,567 B2
• Time in Patent Office: Days
• US Class Current: 600/447
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61B 8/0825 for diagnosis of the breast, e.g. mammography
• CPC Class Codes: A61B 8/485 involving measuring strain or elastic properties
• CPC Class Codes: Y10S 128/92 Computer assisted medical diagnostics
• CPC Class Codes: Y10S 128/924 using artificial intelligence
• CPC Class Codes: Y10S 128/925 Neural network

Abstract

The present invention relates to a method and apparatus for the construction and/or use of multidimensional fields that can be used for high-resolution detection and characterization of features within objects. The multidimensional field is constructed from data that is collected by an array of radiation detectors that substantially surround the object under study. The detected radiation is produced by an array of radiation sources and is subsequently scattered, reflected, transmitted, or diffracted by the object under study and any features within the object under study. In particular embodiments of the invention, the radiation that is used is ultrasonic radiation and the object under study is human or animal tissue or an organ. In this case, the invention permits the detection and identification of cancer by an intelligently trained evaluation system.

Claims

1. Apparatus for detection and characterization of one or more medical pathologies within an object under study, comprising:

(a) a radiation source adapted to emit radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object, said radiation source being disposed so as to be capable of radiating such object;

(b) a plurality of radiation detectors being disposed relative to such object to receive radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the radiation received;

(c) means for controlling said radiation source and said plurality of radiation detectors to emit and receive radiation; and

(d) a device coupled to said plurality of radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of detectors, and to detect and characterize such one or more medical pathologies within said volume.

2. The apparatus according to claim 1, wherein said radiation source comprises a plurality of radiation sources.

3. The apparatus according to claim 2, wherein said plurality of radiation sources is a plurality of ultrasound sources, and said plurality of radiation detectors is a plurality of ultrasound detectors.

4. The apparatus according to claim 3, wherein said plurality of ultrasound sources and said plurality of ultrasound detectors includes at least one device that is used both as an ultrasound source and a ultrasound detector.

5. The apparatus according to claim 3, wherein said plurality of radiation detectors are silicon micro-electro-mechanical systems detectors.

6. The apparatus according to claim 3, wherein said plurality of radiation detectors are piezoelectric detectors.

7. The apparatus according to claim 3, wherein said plurality of radiation detectors are deformable dielectric detectors.

8. The apparatus according to claim 2, wherein said plurality of radiation sources and said plurality of radiation detectors are configured to subtend a solid angle greater than π

sr around said object under study.

9. The apparatus according to claim 8, wherein said plurality of radiation sources and said plurality of radiation detectors are configured to subtend a solid angle greater than 2π

r around said object under study.

10. The apparatus according to claim 2, wherein said plurality of radiation sources produce radiation that is identically phased.

11. The apparatus according to claim 2, wherein said plurality of radiation sources produce radiation that is differently phased.

12. The apparatus according to claim 11, wherein said plurality of radiation sources produce radiation that is phased to focus.

13. The apparatus according to claim 11, wherein said plurality of radiation sources produce radiation that is phased to scan the object under study.

14. The apparatus according to claim 2, wherein said plurality of radiation sources and said plurality of radiation detectors are configured as an ellipsoidal array.

15. The apparatus according to claim 2, wherein said plurality of radiation sources and said plurality of radiation detectors are configured as a hemispherical array.

16. The apparatus according to claim 2, wherein said plurality of radiation sources and said plurality of radiation detectors are configured as a cylindrical array.

17. The apparatus according to claim 2, wherein said plurality of radiation sources and said plurality of radiation detectors are configured as an array that comprises concentric cylinders.

18. The apparatus according to claim 2, wherein said plurality of radiation sources and said plurality of radiation detectors are configured as an array that comprises an inner cylinder and an outer concentric cylindrical arc.

19. The apparatus according to claim 2, wherein said plurality of radiation sources and said plurality of radiation detectors are configured as a conical or truncated conical array.

20. The apparatus according to claim 2, wherein said plurality of radiation sources and said plurality of radiation detectors are configured as a geodesic dome.

21. The apparatus according to claim 2, wherein said plurality of radiation detectors detect at least one of an amplitude, phase, and frequency of said radiation after it has been transmitted through or reflected by said object under study.

22. The apparatus according to claim 2, wherein substantial numbers of said plurality of radiation detectors are integrated in an integrated circuit chip that contains at least one sensor.

23. The apparatus according to claim 22, wherein said integrated circuit chip contains signal processing elements.

24. The apparatus according to claim 2, wherein said plurality of radiation sources produces individually identifiable modulated signals, and at least one of said plurality of radiation detectors includes a matched filter configured to decode at least one of the individually identifiable modulated signals.

25. The apparatus according to claim 24, wherein said modulated signal is modulated according to linear maximal length sequence modulation.

26. The apparatus according to claim 24, wherein said modulated signal is modulated according to the Walsh Function modulation scheme.

27. The apparatus according to claim 2, wherein said object under study comprises a plurality of animal or human tissues.

28. The apparatus according to claim 27, wherein said plurality of animal or human tissues comprises a human breast.

29. The apparatus according to claim 27, wherein said plurality of animal or human tissues comprises a human prostate.

30. The apparatus according to claim 27, wherein said plurality of animal or human tissues comprises a human lung.

31. The apparatus according to claim 27, wherein said plurality of animal or human tissues comprises a section of a human alimentary canal.

32. The apparatus according to claim 27, wherein said plurality of animal or human tissues comprises a human liver.

33. The apparatus according to claim 2, further comprising a matching-impedance contact between said object under study and said plurality of radiation sources and said plurality of radiation detectors;

34. The apparatus according to claim 33, wherein said matching-impedance contact comprises a liquid or gel.

35. The apparatus according to claim 33, wherein said matching-impedance contact comprises a conformal human-shaped suit, and wherein said radiation sources and said radiation detectors are embedded in said conformal human-shaped suit.

36. The apparatus according to claim 1, wherein said radiation source is an electromagnetic radiation source and said plurality of radiation detectors is a plurality of electromagnetic radiation detectors.

37. The apparatus according to claim 1, further comprising a vibration source in contact with said object under study.

38. The apparatus according to claim 1, wherein said medical pathologies comprise cancer.

39. Apparatus for detection and characterization of one or more medical pathologies within an object under study, comprising:

(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such object;

(b) a plurality of ultrasound radiation detectors being disposed relative to such object to receive ultrasound radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the ultrasound radiation received;

(c) means for controlling said plurality of ultrasound radiation sources and said plurality of radiation detectors to emit and receive ultrasound radiation; and

(d) a device coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of detectors, and to detect and characterize such one or more medical pathologies within said volume.

40. Apparatus for detection and characterization of one or more medical pathologies within an object under study, comprising:

(a) a plurality of devices adapted both to emit radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object and to receive radiation scattered by said volume, said plurality of devices being disposed so as to be capable of insonifying such object and said plurality of devices being capable of providing data corresponding to the radiation received;

(b) means for controlling said plurality of devices; and

(c) a computational device coupled to said plurality of devices and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of devices, and to detect and characterize such one or more medical pathologies within said volume.

41. Apparatus for detection and characterization of one or more medical pathologies within an object under study, comprising:

(a) a plurality of devices adapted both to emit ultrasound radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object and to receive ultrasound radiation scattered by said volume, said plurality of devices being disposed so as to be capable of insonifying such object and said plurality of devices being capable of providing data corresponding to the ultrasound radiation received;

(b) means for controlling said plurality of devices; and

(c) a computational device coupled to said plurality of devices and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of devices, and to detect and characterize such one or more medical pathologies within said volume.

42. Apparatus for detection and characterization of one or more medical pathologies within a human breast, comprising:

(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such object;

(b) a plurality of ultrasound radiation detectors being disposed relative to such object to receive ultrasound radiation scattered by said volume, said plurality of ultrasound radiation detectors being capable of providing data corresponding to the ultrasound radiation received;

(c) means for controlling said plurality of ultrasound radiation sources and said plurality of ultrasound radiation detectors to emit and receive ultrasound radiation; and

(d) a device coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors, and to detect and characterize such one or more medical pathologies within said volume.

43. Apparatus for detection and characterization of one or more medical pathologies within an object under study, comprising:

(a) a radiation source adapted to emit radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object, said radiation source being disposed so as to be capable of radiating such object;

(b) at least 5,000 radiation detectors being disposed relative to such object to receive radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the radiation received;

(c) means for controlling said radiation source and said at least 5,000 radiation detectors to emit and receive radiation; and

(d) a device coupled to said at least 5,000 radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said at least 5,000 radiation detectors, and to detect and characterize such one or more medical pathologies within said volume.

44. Apparatus for detection and characterization of cancer within human or animal tissue, comprising:

(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such human or animal tissue;

(b) a plurality of ultrasound radiation detectors being disposed relative to such human or animal tissue to receive ultrasound radiation scattered by said volume, said plurality of ultrasound radiation detectors being capable of providing data corresponding to the ultrasound radiation received;

(c) means for controlling said plurality of ultrasound radiation sources and said plurality of ultrasound radiation detectors to emit and receive ultrasound radiation; and

(d) a device coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors, and to detect and characterize such cancer within said volume.

48. The method according to claim 47, wherein said step of detecting and characterizing such one or more medical pathologies within said volume using said multidimensional field rendering of said volume is accomplished by using an expert system.

49. The method according to claim 47, wherein said step of detecting and characterizing such one or more medical pathologies within said volume using said multidimensional field rendering of said volume is accomplished by using a neural net.

50. The method according to claim 47, wherein said step of constructing a multidimensional field rendering of said volume using the data provided by said plurality of detectors comprises the substeps of:

(a) estimating a three-dimensional shape of said object under study based on said data;

(b) constructing an estimated multidimensional field rendering of said object under study based on said three-dimensional shape and based on physiological data derived from at least one physiological characteristic;

(c) computing estimated radiation data that would be produced by said estimated multidimensional field rendering of said object under study;

(d) testing the difference between said data and said estimated radiation data against a predetermined level of noise;

(e) adjusting said physiological data to calculate a new estimated multidimensional field rendering of said object under study; and

(f) iterating steps (c) through (e) until the difference between said data and said estimated radiation data is below the predetermined level of noise.

51. The method according to claim 47, wherein said radiation is ultrasound radiation.

52. The method according to claim 47, wherein said object under study is a plurality of animal or human tissues.

53. The method according to claim 52, wherein said plurality of animal or human tissues is a human breast.

54. The method according to claim 52, wherein said plurality of animal or human tissues is a human prostate.

55. The method according to claim 52, wherein said plurality of animal or human tissues is a human lung.

56. The method according to claim 52, wherein said plurality of animal or human tissues is a section of a human alimentary canal.

57. The method according to claim 52, wherein said plurality of animal or human tissues is a human liver.

58. The method according to claim 52, wherein said multidimensional field rendering comprises sound speeds and sound absorptions for a plurality of volume elements occupied by said plurality of animal or human tissues.

59. The method according to claim 52, further comprising the step of classifying said plurality of animal or human tissues based on said multidimensional field rendering.

60. The method according to claim 52, further comprising the step of identifying closed volumes in said plurality of animal or human tissues based on said multidimensional field rendering.

61. The method according to claim 60, further comprising the step of determining the quasifractal dimension of said closed volumes based on said multidimensional field rendering.

62. The method according to claim 52, further comprising the step of identifying angiogenesis in said plurality of animal or human tissues based on said multidimensional field rendering.

63. The method according to claim 52, further comprising the step of applying a vibration source in contact with said plurality of animal or human tissues based on said multidimensional field rendering.

64. The method according to claim 52, further comprising the step of identifying microcalcifications in said plurality of tissues based on said multidimensional field rendering.

65. The method according to claim 52, further comprising the step of identifying the electrical impedance of said plurality of tissues based on said multidimensional field rendering.

66. The method according to claim 47, further comprising the step of storing said multidimensional field rendering.

67. The method according to claim 66, wherein said step of storing said multidimensional field rendering is accomplished by lossless compression.

68. The method according to claim 47, further comprising the step of comparing said multidimensional field rendering with an earlier stored multidimensional field rendering of said object under study.

69. The method according to claim 68, wherein said step of comparing said multidimensional field rendering with an earlier stored multidimensional field rendering of said object under study comprises the substep of morphing said earlier stored multidimensional field rendering into said multidimensional field rendering.

45. Apparatus for detection and characterization of cancer within human or animal tissue, comprising:

(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such human or animal tissue;

(b) a plurality of ultrasound radiation detectors being disposed relative to such human or animal tissue to receive ultrasound radiation scattered by said volume said plurality of ultrasound radiation detectors being capable of providing data corresponding to the ultrasound radiation received;

(c) means for controlling said plurality of ultrasound radiation sources and said plurality of ultrasound radiation detectors to emit and receive ultrasound radiation; and

(d) an expert system coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume, using the data provided by said plurality of ultrasound radiation detectors, and to detect and characterize such cancer within said volume.

46. Apparatus for detection and characterization of cancer within human or animal tissue, comprising:

(a) a plurality of ultrasound radiation sources adapted to emit ultrasound radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object, said plurality of ultrasound radiation sources being disposed so as to be capable of insonifying such human or animal tissue;

(b) a plurality of ultrasound radiation detectors being disposed relative to such human or animal tissue to receive ultrasound radiation scattered by said volume, said plurality of ultrasound radiation detectors being capable of providing data corresponding to the ultrasound radiation received;

(c) means for controlling said plurality of ultrasound radiation sources and said plurality of ultrasound radiation detectors to emit and receive ultrasound radiation; and

(d) a neural net coupled to said plurality of ultrasound radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors, and to detect and characterize such cancer within said volume.

47. Method for detection and characterization of one or more medical pathologies within an object under study, comprising the steps of:

(a) irradiating, using a radiation source disposed so as to be capable of irradiating such object, upon a volume within the object under study with radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using a plurality of radiation detectors being disposed relative to such object, radiation scattered by said volume within the object and providing data corresponding to the radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of detectors; and

(d) detecting and characterizing such one or more medical pathologies within said volume using said multidimensional field rendering of said volume.

70. Method for detection and characterization of one or more medical pathologies within an object under study, comprising the steps of:

(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such object, upon a volume within the object under study with ultrasound radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using a plurality of ultrasound radiation detectors being disposed relative to such object, ultrasound radiation scattered by said volume within the object and providing data corresponding to the ultrasound radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and

(d) detecting and characterizing such one or more medical pathologies within said volume using said multidimensional field rendering of said volume.

71. Method for detection and characterization of one or more medical pathologies within an object under study, comprising the steps of:

(a) irradiating, using a plurality of devices disposed so as to be capable of irradiating such object, upon a volume within the object under study with radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using such plurality of devices being disposed relative to such object, radiation scattered by said volume within the object and providing data corresponding to the radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of devices; and

(d) detecting and characterizing such one or more medical pathologies within said volume using said multidimensional field rendering of said volume.

72. Method for detection and characterization of one or more medical pathologies within an object under study, comprising the steps of:

(a) irradiating, using a radiation source disposed so as to be capable of irradiating such object, upon a volume within the object under study with radiation within a redetermined frequency range or at a predetermined frequency;

(b) receiving, using at least 5,000 radiation detectors being disposed relative to such object, radiation scattered by said volume within the object and providing data corresponding to the radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said at least 5,000 radiation detectors; and

(d) detecting and characterizing such one or more medical pathologies within said volume using said multidimensional field rendering of said volume.

73. Method for detection and characterization of one or more medical pathologies within an object under study, comprising the steps of:

(a) insonifying, using a plurality of ultrasound devices disposed so as to be capable of insonifying such object, upon a volume within the object under study with ultrasound radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using such plurality of ultrasound devices being disposed relative to such object, ultrasound radiation scattered by said volume within the object and providing data corresponding to the ultrasound radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound devices; and

(d) detecting and characterizing such one or more medical pathologies within said volume using said multidimensional field rendering of said volume.

74. Method for detection and characterization of one or more medical pathologies within a human breast, comprising the steps of:

(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such human breast, upon a volume within the human breast with ultrasound radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using a plurality of ultrasound radiation detectors being disposed relative to such human breast, ultrasound radiation scattered by said volume within the human breast and providing data corresponding to the ultrasound radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and

(d) detecting and characterizing such one or more medical pathologies within said volume using said multidimensional field rendering of said volume.

75. Method for detection and characterization of cancer within an human or animal tissue, comprising the steps of:

(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such human or animal tissue, upon a volume within the human or animal tissue with ultrasound radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using a plurality of ultrasound radiation detectors being disposed relative to such human or animal tissue, ultrasound radiation scattered by said volume within the human or animal tissue and providing data corresponding to the ultrasound radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and

(d) detecting and characterizing such cancer within said volume using said multidimensional field rendering of said volume.

76. Method for detection and characterization of cancer within an human or animal tissue, comprising the steps of:

(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such human or animal tissue, upon a volume within the human or animal tissue with ultrasound radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using a plurality of ultrasound radiation detectors being disposed relative to such human or animal tissue, ultrasound radiation scattered by said volume within the human or animal tissue and providing data corresponding to the ultrasound radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and

(d) detecting and characterizing such cancer within said volume using an expert system to analyze said multidimensional field rendering of said volume.

77. Method for detection and characterization of cancer within an human or animal tissue, comprising the steps of:

(a) insonifying, using a plurality of ultrasound radiation sources disposed so as to be capable of insonifying such human or animal tissue, upon a volume within the human or animal tissue with ultrasound radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using a plurality of ultrasound radiation detectors being disposed relative to such human or animal tissue, ultrasound radiation scattered by said volume within the human or animal tissue and providing data corresponding to the ultrasound radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of ultrasound radiation detectors; and

(d) detecting and characterizing such cancer within said volume using a neural net to analyze said multidimensional field rendering of said volume.

78. Apparatus for detection and characterization of one or more distinct features within an object under study, comprising:

(a) a radiation source adapted to emit radiation within a predetermined frequency range or at a predetermined frequency onto a volume within such object, said radiation source being disposed so as to be capable of radiating such object;

(b) a plurality of radiation detectors being disposed relative to such object to receive radiation scattered by said volume, said plurality of detectors being capable of providing data corresponding to the radiation received;

(c) means for controlling said radiation source and said plurality of radiation detectors to emit and receive radiation; and

(d) a device coupled to said plurality of radiation detectors and configured to construct a multidimensional field rendering of said volume using the data provided by said plurality of detectors, and to detect and characterize such one or more distinct features within said volume.

79. Method for detection and characterization of one or more distinct features within an object under study, comprising the steps of:

(a) irradiating, using a radiation source disposed so as to be capable of irradiating such object, upon a volume within the object under study with radiation within a predetermined frequency range or at a predetermined frequency;

(b) receiving, using a plurality of radiation detectors being disposed relative to such object, radiation scattered by said volume within the object and providing data corresponding to the radiation received;

(c) constructing a multidimensional field rendering of said volume using the data provided by said plurality of detectors; and

(d) detecting and characterizing such one or more distinct features within said volume using said multidimensional field rendering of said volume.

80. Method for destruction of one or more medical pathologies within an object under study, comprising the steps of:

(a) constructing or retrieving a multidimensional field rendering of a volume of an object under study;

(b) detecting and characterizing such one or more medical pathologies based on said multidimensional field rendering; and

(b) irradiating such one or more medical pathologies with high-intensity focused radiation to destroy or eliminate such one or more medical pathologies.

81. Method for destruction of one or more distinct features within an object under study, comprising the steps of:

(a) constructing or retrieving a multidimensional field rendering of a volume of an object under study;

(b) detecting and characterizing such one or more distinct features based on said multidimensional field rendering; and

(b) irradiating such one or more distinct features with high-intensity focused radiation to destroy or eliminate such one or more medical pathologies.