Bi-laminar, hyaluronan coatings with silver- based anti-microbial properties

• US 20020068093A1
• Filed: 08/29/2001
• Published: 06/06/2002
• Est. Priority Date: 08/30/2000
• Status: Active Grant

• Current Assignee: BioCoat, Inc., Sciessent, LLC
• Original Assignee: BioCoat, Inc.
• Inventors: Trogolo, Jeffrey A., Pervin, Elizabeth, Johnston, James B., Stahl, Amy, Pastecki, Elizabeth A., Hyman, Mark
• Granted Patent: US 6,866,859 B2
• Time in Patent Office: Days
• US Class Current: 424/618
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/236 Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/608 having two or more layers
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/10 Inorganic materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: C08K 3/34 Silicon-containing compounds
• CPC Class Codes: C08K 9/02 Ingredients treated with inorganic substances
• CPC Class Codes: C08L 5/00 Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

An article including a surface having a coating thereon, in which the coating includes a base coat, firmly adhered to the surface, and a hydrophilic, biocompatible top-coat. An antibiotic ceramic component is dispersed in one or both of the base coat and top-coat. Preferably, the ceramic component is dispersed in the base coat. In a preferred embodiment, the ceramic component is a zeolite with silver ions exchanged onto internal acidic sites of the zeolite, and the top-coat includes a polysaccharide, such as hyaluronan. The zeolite is highly effective in imparting anti-microbial character to the coating.

Claims

1. An article including a surface having a coating thereon, said coating comprising:

(a) a polysaccharide component; and

(b) an antibiotic ceramic component dispersed within the polysaccharide component.

2. The article of claim 1 wherein the antibiotic ceramic component comprises a zeolite material.

3. The article of claim 2 wherein the zeolite material comprises silver ions ion-exchanged thereon.

4. The article of claim 1, wherein the polysaccharide component comprises hyaluronan.

5. The article of claim 1, comprising a polymeric tubing.

6. The article of claim 1, comprising a polymeric catheter tubing.

7. The article of claim 1, comprising a tubing made from a material selected from the group consisting of ethyl vinyl acetate and polyurethane.

8. The article of claim 1, comprising a polymeric material providing said surface.

9. The article of claim 1, wherein the surface is formed of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.

10. An article including a surface having a coating thereon, said coating comprising:

(a) a base coat adhered to said surface, and

(b) a hydrophilic, biocompatible top-coat which is chemically grafted to said base coat,

wherein the base coat includes an antibiotic ceramic component dispersed within the base coat.

11. The article of claim 10, wherein the top-coat includes a polysaccharide component.

12. The article of claim 10, wherein the antibiotic ceramic component comprises a zeolite material.

13. The article of claim 12 wherein the zeolite material comprises silver ions ion-exchanged thereon.

14. The article of claim 11, wherein the polysaccharide component comprises hyaluronan.

15. The article of claim 10, comprising a polymeric tubing.

16. The article of claim 10, comprising a polymeric catheter tubing.

17. The article of claim 10, comprising a tubing made of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.

18. The article of claim 10, comprising a polymeric material providing said surface.

19. The article of claim 10, wherein the surface is formed of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.

20. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:

coating the object on a surface portion thereof with a coating comprising;

(i) a polysaccharide component; and

(ii) an antibiotic ceramic component dispersed within the polysaccharide component.

21. The method of claim 20, wherein the antibiotic ceramic component comprises a zeolite component.

22. The method of claim 20, wherein the zeolite component comprises silver ions ion-exchanged thereon.

23. The method of claim 20, wherein the polysaccharide component comprises hyaluronan.

24. The method of claim 20, wherein the object comprises polymeric tubing.

25. The method of claim 20, wherein the object comprises polymeric catheter tubing.

26. The method of claim 20, wherein the object comprises a tubing made of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.

27. The method of claim 20, wherein the object comprises a polymeric material.

28. The method of claim 20, wherein the object comprises a material selected from the group consisting of ethyl vinyl acetate and polyurethane.

29. An article comprising a hyaluronan coating containing a silver ion exchanged zeolite.

30. An article comprising a substrate, a base coat, and a top-coat containing hyaluronan, wherein the base coat contains a silver ion exchanged zeolite.

31. A method for providing an object with antibiotic properties for introduction of the object into an animal, said method comprising:

coating the object on a surface portion thereof with a coating comprising;

(i) a base coat which adheres firmly to said surface portion, and polysaccharide component; and

(ii) a hydrophilic, biocompatible top-coat, the top-coat being chemically grafted to said base coat,

the method further comprising dispersing an antibiotic ceramic component within said base coat.

32. The method of claim 31, wherein the antibiotic ceramic component comprises a zeolite component.

33. The method of claim 31, wherein the zeolite component comprises silver ions ion-exchanged thereon.

34. The method of claim 31, wherein the polysaccharide component comprises hyaluronan.

35. The method of claim 31, wherein the object comprises polymeric tubing.

36. The method of claim 31, wherein the object comprises polymeric catheter tubing.

37. The method of claim 31, wherein the object comprises a tubing made of a material selected from the group consisting of ethyl vinyl acetate and polyurethane.

38. The method of claim 31, wherein the object comprises a polymeric material.

39. The method of claim 31, wherein the object comprises a material selected from the group consisting of ethyl vinyl acetate and polyurethane.

40. An article having a coating which includes a polysaccharide and a silver ion exchanged zeolite.

41. An article having a coating which includes hyaluronan and a silver ion exchanged zeolite.