Products with biofunctional coating
First Claim
1. A product comprising a solid surface, a multilayer system of at least two covalently interconnected layers of a polymeric material covalently attached to said surface, and a biofunctional layer covalently attached to said multilayer system.
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Accused Products
Abstract
The invention relates to products comprising a solid surface, a multilayer system of at least two covalently interconnected layers of a polymeric material covalently attached to said surface, and a biofunctional layer covalently attached to said multilayer system. The biofunctional layer may comprise a bioactive ingredient to make the product useful for numerous applications, such as biosensors, implants, sample containers, affinity sensor arrays and affinity chromatography media.
The invention also relates to methods for making such products.
The use of a multilayer system of organic polymers allows to obtain almost identical biofunctional surfaces on very different substrates and provides a more complete shielding of the original surface of the substrate which reduces non-specific adsorption of biomolecules.
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Citations
26 Claims
- 1. A product comprising a solid surface, a multilayer system of at least two covalently interconnected layers of a polymeric material covalently attached to said surface, and a biofunctional layer covalently attached to said multilayer system.
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21. A method for making a product having a solid surface coated with polymeric layers and a biofunctional layer, comprising the steps of
(a) functionalizing said surface; -
(b) covalently coupling a polymer layer with one type of functional group to said surface;
(c) covalently coupling a polymer layer with a second type of functional groups to the previous polymer layer, optionally after having activated the functional groups of said previous polymer layer with a suitable activating reagent;
(d) optionally repeating steps (b) and (c); and
(e) covalently coupling a biofunctional layer which is suitable for the binding of bioactive molecules and/or the prevention of non-specific adsorption, to the assembly. - View Dependent Claims (22, 23, 24, 25, 26)
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Specification