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Proteomic analysis by parallel mass spectrometry

  • US 20020068366A1
  • Filed: 04/13/2001
  • Published: 06/06/2002
  • Est. Priority Date: 04/13/2000
  • Status: Abandoned Application
First Claim
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1. A method for analysis of proteins in a biological system comprising:

  • providing a biological system;

    exposing the system to a stimulus;

    sampling the biological system at multiple time intervals after exposing the system to the stimulus, treating the multiple samples by separation technique to provide multiple protein samples suitable for analysis by mass spectrometry, and analyzing the multiple samples to determine changes in protein abundance as a function of time after exposing the biological system to stimulus, said analyzing including providing a parallel array of mass spectrometry systems adapted for protein analysis, and directing mass spectral data from the mass spectrometry systems in said array to a common computing device, said mass spectral data being indicative of the identity and the abundance of protein in said multiple sample, and correlating said mass spectral data as a function of time.

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