Chondroprotective/restorative compositions and methods of use thereof

• US 20020068718A1
• Filed: 10/02/2001
• Published: 06/06/2002
• Est. Priority Date: 10/03/2000
• Status: Active Grant

• Current Assignee: Scott W. Pierce
• Original Assignee: Scott W. Pierce
• Inventors: Pierce, Scott W.
• Granted Patent: US 6,924,273 B2
• Time in Patent Office: Days
• US Class Current: 514/54
• CPC Class Codes: A23K 50/20 for horses
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/7008 Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
• CPC Class Codes: A61K 31/728 Hyaluronic acid

Abstract

The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function including joint mobility, the reduction or inhibition of metabolic activity of chondrocytes, the activity of enzymes that degrade cartilage, the reduction or inhibition of the production of Hyaluronic acid, said method comprising orally administering to a mammalian species a therapeutically effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof. Additionally, compositions containing hyaluronic acid; chondroitin sulfate, and glucosamine sulfate in a paste formulation are also disclosed which can be administered on their own or can be used as a feed additive.

Claims

1. A method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function, the reduction or inhibition of metabolic activity of chondrocytes, the activity of enzymes that degrade cartilage, the reduction or inhibition of the production of Hyaluronic acid in a mammal, said method comprising orally administering to said mammal a therapeutically effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof.

2. The method of claim 1 further including an effective amount of Glucosamine or its pharmaceutically acceptable salts.

3. The method of claim 1 further including an effective amount of chondroitin or its pharmaceutically acceptable salts.

4. The method of claim 2 wherein said pharmaceutically acceptable salt is glucosamine sulfate.

5. The method of claim 3 wherein said pharmaceutically acceptable salt is chondroitin sulfate.

6. The method of claim 1 further including therapeutically effective amounts of glucosamine sulfate and chondroitin sulfate.

7. The method according to claim 1 wherein said hyaluronic acid is uncrosslinked.

8. The method according to claim 1 wherein said pharmaceutically acceptable salt is sodium hyaluronate.

9. The method according to claim 8 wherein said therapeutically effective amount of sodium hyaluronate is in the range of 10 mg to 2000 mg.

10. A Chondroprotective/Restorative composition comprising an effective amount Hyaluronic Acid or its pharmaceutically acceptable salts and optionally a pharmaceutically acceptable carrier.

14. The Chondroprotective/Restorative composition of claim 10 further including nutritionally effective amounts of a supplement selected from the group consisting of vitamin A, D and E, ascorbic acid, biotin, panthothenic, choline, niacin, pyridoxine, riboflavin, thiamine, calcium, phosphorus, NaCl, copper, iron, manganese, iodine, zinc and combinations thereof.

11. A Chondroprotective/Restorative composition comprising:

(a) an effective amount of Glucosamine sulfate;

(b) an effective amount Hyaluronic Acid or pharmaceutically acceptable salts thereof; and

(c) optionally a pharmaceutically acceptable carrier.

15. The Chondroprotective/Restorative composition of claim 11 further including nutritionally effective amounts of a supplement selected from the group consisting of vitamin A, D and E, ascorbic acid, biotin, panthothenic, choline, niacin, pyridoxine, riboflavin, thiamine, calcium, phosphorus, NaCl, copper, iron, manganese, iodine, zinc and combinations thereof.

16. The Chondroprotective/Restorative composition of claim 12 further including nutritionally effective amounts of a supplement selected from the group consisting of vitamin A, D and E, ascorbic acid, biotin, panthothenic, choline, niacin, pyridoxine, riboflavin, thiamine, calcium, phosphorus, NaCl, copper, iron, manganese, iodine, zinc and combinations thereof.

17. The Chondroprotective/Restorative composition of claim 13 further including nutritionally effective amounts of a supplement selected from the group consisting of vitamin A, D and E, ascorbic acid, biotin, panthothenic, choline, niacin, pyridoxine, riboflavin, thiamine, calcium, phosphorus, NaCl, copper, iron, manganese, iodine, zinc and combinations thereof.

19. The animal feed of claim 18 further including an effective amount of Glucosamine sulfate.

20. The animal feed of claim 19 further including an effective amount of Chondroitin sulfate.

21. The animal feed of claim 20 further including molasses.

22. The animal feed of claim 21 further including nutritionally effective amounts of a supplement selected from the group consisting of vitamin A, D and E, ascorbic acid, biotin, panthothenic, choline, niacin, pyridoxine, riboflavin, thiamine, calcium, phosphorus, NaCl, copper, iron, manganese, iodine, zinc and combinations thereof.

23. The animal feed of claim 22 in the form of a paste.

24. The animal feed according to claim 23, which is a cat feed.

25. The animal feed according to claim 23, which is a dog feed.

26. The animal feed according to claim 23, which is a horse feed.

28. The therapeutic and Chondroprotective/Restorative composition of claim 27 wherein said therapeutic drug is selected from the group consisting of acetaminophen, acetic acid, acetylsalicylic acid, buffered acetylsalicylic acid, albuterol, albuterol sulfate, ethanol isopropanol, allantoin, aloe, aluminum acetate, aluminum carbonate, aluminum chlorohydrate, aluminum hydroxide, alprozolam, amino acids, aminobenzoic acid, amoxicillin, ampicillin, amsacrine, amsalog, anethole, aspartame, atenolol, bacitracin, balsam peru, beclomethasone dipropionate, benzocaine, benzoic acid, benzophenones, benzoyl peroxide, biotin, bisacodyl, bornyl acetate, bromopheniramine maleate, buspirone, caffeine, calamine, calcium, calcium carbonate, calcium casinate, calcium hydroxide, camphor, captopril, cascara sagrada, castor oil, Cephalosporins, cefaclor, cefadroxil, cephalexin, cetylalcohol, cetylpyridinium chloride, chelated minerals, chloramphenicol, chlorcyclizine hydrochloride, chlorhexidine gluconate, chloroxylenol, chloropentostatin, chlorpheniramine maleate, cholestyramine resin, choline bitartrate, cimetidine hydrochloride, cinnamedrine hydrochloride, citalopram, citric acid, Clenbuterol, cocoa butter, cod liver oil, codeine and codeine phosphate, clonidine, clonidine hydrochloride, clorfibrate, ciprofloxacin HCl, cyanocobalamin, cyclizine hydrochloride, DMSO, danthron, Dantrium, dexamethazone, dexbrompheniranime maleate, dextromethorphan hydrobromide, diazapam, dibucaine, diclofenac sodium, digoxin, diltiazem, dimethicone, dioxybenzone, diphenhydramine citrate, diphenhydramine hydrochloride, docusate calicum, docusate potassium, docusate sodium, doxycycline hyclate, doxylamine succinate, efaroxan, enalapril, enoxacin, erythromycin, estropipate, ethinyl estradiol, ephedrine, epinephrine bitartrate, erythropoietin, eucalyptol, ferrous fumarate, ferrous gluconate, ferrous sulfate, folic acid, fosphenytoin, Flunixin Meglumine, fluoxetine HCl, furosemide, gabapentan, gentamicin, Gentocin sulfate, gemfibrozil, glipizide, glycerin, glyceryl stearate, griseofulvin, guaifenesin, hexylresorcinol, hydrochlorothiaxide, hydrocodone bitartrate, hydrocortisone, hydrocortisone acetate, 8-hydroxyquinoline sulfate, ibuprofen, indomethacin, inositol, insulin, iodine, ipecac, iron, isoxicam, Isoxuprine, ketamine, Ketofin, koalin, lactic acid, lanolin, lecithin, lidocaine, lidocaine hydrochloride, lifinopril, liotrix, lovastatin, MSM (methylsulfonylmethane), magnesium carbonate, magnesium hydroxide, magnesium salicylate, magnesium trisilocate, mefenamic acid, meclofenanic acid, meclofenamate sodium, medroxyprogesterone acetate, methenamine, mandelate, Methocarbamol, menthol, meperidine hydrochloride, metaproterenol sulfate, methyl nicotinate, methyl salicylate, methylcellulose, methsuximide, metromidazole, metromidazole hydrochloride, metoprolol tartrate, miconazole nitrate, mineral oil, minoxidil, morphine, naproxen, naproxen sodium, nifedipine, neomycin sulfate, Neomycin-Bacitracin, niacin, niacinamide, nicotine, nicotinamide, nitroglycerin, nonoxynol-9, norethindone, norethindone acetate, nystatin, octoxynol, octyl dimethyl PABA, octyl methoxycinnamate, omega-3 polyunsaturated fatty acids, omeprazole, oxolinic acid, oxybenzone, oxtriphylline, para-aminobenzoic acid (PABA), padimate O, paramethadione, Penicillin, pentastatin, peppermint oil, pentaerythriol tetranitrate, pentobarbital sodium, pheniramine maleate, phenobarbital, phenol, phenolphthalein, phenybutazone, phenylephrine hydrochloride, phenylpropanolamine, phenylpropanolamine hydrochloride, phenytoin, phenelzine sulfate, pirmenol, piroxicam, polymycin B sulfate, potassium chloride, potassium nitrate, prazepam, prednisone, prednisolone, procainamide hydrochloride, procaterol, propoxyphene, propoxyphene HCl, propoxyphene napsylate, pramiracetin, pramoxine, pramoxine hydrochloride, propronolol HCl, pseudoephedrine hydrochloride, pseudoephedrine sulfate, pyridoxine, quinapril, quinidine gluconate, quinestrol, ralitoline, ranitadine, resorcinol, riboflavin, salicylic acid, sesame oil, shark liver oil, simethicone, sodium bicarbonate, sodium citrate, sodium fluoride, sodium monofluorophosphate, Sulfa-drugs, sulfanethoxazole, sulfur, tacrine, tacrine HCl, theophylline, terfenidine, thioperidone, trimetrexate, triazolam, timolol maleate, tretinoin, tetracycline hydrochloride, tolmetin, tolnaftate, triamcinolone, triclosan, triprolidine hydrochloride, undecylenic acid, vancomycin, verapamil HCl, vidaribine phosphate, vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, witch hazel, xylometazoline hydrochloride, zinc, zinc sulfate, and zinc undecylenate.

30. The Chondroprotective/Restorative composition of claim 29 further including glucosamine sulfate.

31. The Chondroprotective/Restorative composition of claim 30 further including chondroitin sulfate.

32. The Chondroprotective/Restorative composition of claim 31 further including nutritionally effective amounts of vitamins and minerals.

33. A method of enhancing chondrocyte synthesis in a mammal which method comprises administering orally to said mammal an effective amount of the composition according to claim 31.

34. A method for inhibiting enzymes that degrade cartilage, and reduce pain and synovitis in a mammal which method comprises administering orally to said mammal an effective amount of the composition according to claim 31.

36. The Chondroprotective/Restorative composition of claim 35 further including glucosamine sulfate.

37. The Chondroprotective/Restorative composition of claim 35 further including chondroitin sulfate.

38. The Chondroprotective/Restorative composition of claim 35 further including nutritionally effective amounts of vitamins and minerals.

12. A Chondroprotective/Restorative composition comprising:

(b) an effective amount of Chondroitin sulfate;

(b) an effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof; and

(c) optionally a pharmaceutically acceptable carrier.

13. A Chondroprotective/Restorative composition comprising

(a) an effective amount of Glucosamine sulfate;

(b) an effective amount of Chondroitin sulfate;

(c) an effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof; and

(d) optionally a pharmaceutically acceptable carrier.

18. An animal feed having Chondroprotective/Restorative benefits comprising:

(a) a nutritionally effective feed base selected from the group consisting of grains, proteins, fats and mixtures thereof; and

(b) an effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof.

27. A therapeutic and Chondroprotective/Restorative composition comprising:

(a) an effective amount of hyaluronic Acid or its pharmaceutically acceptable salts;

(b) an effective amount of a therapeutic drug; and

(c) optionally a pharmaceutically acceptable carrier.

29. A Chondroprotective/Restorative composition in paste form comprising:

(a) an effective amount of Hyaluronic Acid or its pharmaceutically acceptable salts; and

(b) a sufficient amount of molasses to make a paste.

35. A Chondroprotective/Restorative composition in gel form comprising:

(a) an effective amount of Hyaluronic Acid or its pharmaceutically acceptable salts;

(b) water; and

(c) a sufficient amount of carboxymethylcellulose or its sodium salt to make a gel.