Systems and methods providing functional magnetic resonance imaging data analysis services

• US 20020069242A1
• Filed: 12/06/2000
• Published: 06/06/2002
• Est. Priority Date: 12/06/1999
• Status: Abandoned Application

• Current Assignee: Emory University
• Original Assignee: Emory University
• Inventors: Berns, Gregory S.
• Application Number:
  US09/732,219
• Publication Number:
  US 20020069242A1
• Time in Patent Office: Days
• US Class Current: 709/203
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/4806 Functional imaging of brain activation

Abstract

Systems and method for providing functional magnetic resonance imaging (fMRI) data analysis and comparison services are provided. The system comprises an interface, a processing engine, an fMRI comparison engine, a searchable database, and a billing functionality. The interface may be adapted to receive from a client via a communications network a client data set containing information related to a functional magnetic resonance image. The processing engine may be programmed to identify a plurality of spatially independent components related to the client data set by applying a blind source separation algorithm to the client data set. The searchable database may include information related to (i) a plurality of sets of independent components corresponding to a plurality of functional magnetic resonance image data sets and (ii) a set of fundamental independent components comprising common components which exist in a scientifically-significant portion of the plurality of sets of independent components. The fMRI comparison engine may be programmed to compare the plurality of independent components related to the client data set to the set of fundamental independent components in the database. The interface may be coupled to the comparison engine and adapted to deliver to the client information based on the comparison via the communications network. The billing functionality may be coupled to the interface and adapted to charge the client for delivering the information based on the comparison.

Claims

1. A method of providing functional magnetic resonance imaging data analysis services, comprising:

receiving from a client via a communications network a data set containing information related to a functional magnetic resonance image of an individual'"'"'s brain;

identifying a plurality of spatially independent components related to the data set by applying a blind source separation algorithm to the data set; and

delivering to the client via a communications network information related to the plurality of independent components of the data set.

2. The method of claim 1, further comprising reducing the dimensionality of the data set by applying a singular value decomposition algorithm to the data set prior to identifying spatially independent components of the data set.

3. The method of claim 1, further comprising charging the client for delivering the independent components of the data set.

4. The method of claim 1, wherein the receiving from a client and the delivering to the client is via the Internet and the client views the information related to the plurality of independent components of the data set with a web browser.

5. The method of claim 1, further comprising storing the plurality of independent components in a database containing information related to a plurality of sets of other independent components, each set of other independent components corresponding to another data set related to a distinct functional magnetic resonance image of another individual'"'"'s brain.

6. The method of claim 1, further comprising receiving a request from the client via the communications network to compare the plurality of independent components to the plurality of sets of other independent components in the database.

7. The method of claim 6, further comprising (i) comparing the plurality of independent components to the plurality of sets of independent components in the database and (ii) delivering to the client via the communications network information based on the comparison.

8. The method of claim 7, further comprising charging the client for delivering the information based on the comparison.

9. A method of developing a functional magnetic resonance image database containing information related to a plurality of data sets, each of the plurality of data sets corresponding to a different functional magnetic resonance image, comprising:

offering functional magnetic resonance imaging data analysis services, the services comprising (i) enabling a client to transmit via a communications network a client data set, the client data set containing information related to a functional magnetic resonance image, (ii) identifying a plurality of spatially independent components related to the client data set by applying a blind source separation algorithm to the data set, and (iii) delivering to the client via the communications network information related to the plurality of independent components related to the client data set;

receiving a plurality of client data sets from a plurality of clients via the communications network; and

providing the functional magnetic resonance imaging data analysis services to the plurality of clients.

10. The method of claim 9, further comprising storing the plurality of sets of independent components corresponding to the plurality of clients in the database.

11. The method of claim 10, further comprising comparing each of the plurality of sets of independent components to the other of the plurality of sets of independent components.

12. The method of claim 11, further comprising identifying common components which exist in a scientifically-significant portion of the plurality of sets of independent components.

13. The method of claim 9, wherein the services further comprise reducing the dimensionality of the client data set by applying a singular value decomposition algorithm to the client data set prior to identifying a plurality of spatially independent components related to the client data set.

14. The method of claim 9, further comprising charging the plurality of clients for the services.

15. The method of claim 9, wherein the communications network is the Internet and the plurality of clients view the information related to the plurality of independent components of the data set with a web browser.

17. The method of claim 16, further comprising comparing the plurality of independent components related to the client data set to the set of fundamental independent components in the database.

18. The method of claim 17, further comprising delivering to the client information based on the comparison via the communications network.

19. The method of claim 16, further comprising reducing the dimensionality of the client data set by applying a singular value decomposition algorithm to the client data set prior to identifying spatially independent components of the client data set.

20. The method of claim 18, further comprising charging the client for delivering the information based on the comparison.

21. The method of claim 18, wherein the receiving from a client and the delivering to the client is via the Internet and the client views the information with a web browser.

22. The method of claim 16, further comprising modifying the set of fundamental independent components in the database based on the plurality of independent components related to the client data set.

24. The system of claim 23, further comprising a means for reducing the dimensionality of the data set by applying a singular value decomposition algorithm to the data set prior to identifying spatially independent components of the data set.

25. The system of claim 23, further comprising a means for charging the client for delivering the information related to the plurality of independent components related to the data set.

26. The system of claim 23, wherein the communications network is the Internet and the client views the information related to the plurality of independent components related to the data set with a web browser.

27. The system of claim 23, further comprising a means for storing the plurality of independent components.

28. The system of claim 23, further comprising a means for receiving a request from the client via the communications network to compare the plurality of independent components to information related to a plurality of sets of other independent components, each set of other independent components corresponding to another data set related to a distinct functional magnetic resonance image.

29. The system of claim 28, further comprising a means for comparing the plurality of independent components to the plurality of sets of independent components in the database and a means for delivering to the client via the communications network information based on the comparison.

30. The system of claim 29, further comprising a means for charging the client for delivering the information based on the comparison.

16. A method of providing functional magnetic resonance imaging comparison services, comprising:

receiving from a client via a communications network a client data set containing information related to a functional magnetic resonance image;

identifying a plurality of spatially independent components related to the client data set by applying a blind source separation algorithm to the client data set; and

receiving from the client a request to compare the plurality of independent components to a set of fundamental independent components in a database, the set of fundamental independent components comprising common components which exist in a scientifically-significant portion of a plurality of sets of independent components corresponding to a plurality of functional magnetic resonance image data sets contained in the database.

23. A system for providing functional magnetic resonance imaging data analysis services, comprising:

a means for receiving from a client via a communications network a data set containing information related to a functional magnetic resonance image of an individual'"'"'s brain;

a means for identifying a plurality of spatially independent components related to the data set by applying a blind source separation algorithm to the data set; and

a means for delivering to the client via a communications network information related to the plurality of independent components of the data set.

31. A system for developing a functional magnetic resonance image database containing information related to a plurality of data sets, each of the plurality of data sets corresponding to a different functional magnetic resonance image, comprising:

a means for offering functional magnetic resonance imaging data analysis services, the services comprising (i) enabling a client to transmit via a communications network a client data set, the client data set containing information related to a functional magnetic resonance image, (ii) identifying a plurality of spatially independent components related to the client data set by applying a blind source separation algorithm to the data set, and (iii) delivering to the client via the communications network information related to the plurality of independent components related to the client data set;

a means for receiving a plurality of client data sets from a plurality of clients via the communications network; and

a means for providing the functional magnetic resonance imaging data analysis services to the plurality of clients.

32. The system of claim 31, further comprising a means for storing the plurality of sets of independent components corresponding to the plurality of clients in the database.

33. The system of claim 32, further comprising a means for comparing each of the plurality of sets of independent components to the other of the plurality of sets of independent components.

34. The system of claim 33, further comprising a means for identifying common components which exist in a scientifically-significant portion of the plurality of sets of independent components.

35. The system of claim 31, wherein the services further comprise reducing the dimensionality of the client data set by applying a singular value decomposition algorithm to the client data set prior to identifying a plurality of spatially independent components related to the client data set.

36. The system of claim 31, further comprising a means for charging the plurality of clients for the services.

37. The system of claim 31, wherein the communications network is the Internet and the plurality of clients view the information related to the plurality of independent components with a web browser.

39. The system of claim 38, further comprising a means for comparing the plurality of independent components related to the client data set to the set of fundamental independent components in the database.

40. The system of claim 39, further comprising a means for delivering to the client information based on the comparison via the communications network.

41. The system of claim 38, further comprising a means for reducing the dimensionality of the client data set by applying a singular value decomposition algorithm to the client data set prior to identifying spatially independent components of the client data set.

42. The system of claim 40, further comprising a means for charging the client for delivering the information based on the comparison.

43. The system of claim 40, wherein the communications network is the Internet and the client views the information with a web browser.

44. The system of claim 39, wherein the set of fundamental independent components in the database is modified based on the plurality of independent components related to the client data set.

46. The system of claim 45, wherein the processing engine is further programmed to reduce the dimensionality of the data set by applying a singular value decomposition algorithm to the data set prior to identifying a plurality of spatially independent components.

47. The system of claim 46, further comprising a billing functionality coupled to the interface for charging the client for delivering the independent components of the data set.

48. The system of claim 46, wherein the communications network is the Internet and the interface is a web server.

49. The system of claim 46, further comprising a database for storing the plurality of independent components.

50. The system of claim 46, wherein the interface is further adapted to receive a request from the client via the communications network to compare the plurality of independent components to information related to a plurality of sets of other independent components stored in the database, each set of other independent components corresponding to another data set related to a distinct functional magnetic resonance image.

51. The system of claim 50, wherein the processing engine is further programmed to compare the plurality of independent components to the plurality of sets of independent components in the database and the interface is further adapted to deliver to the client via the communications network information based on the comparison.

52. The system of claim 51, further comprising a billing functionality coupled to the interface for charging the client for delivering the information based on the comparison.

38. A system for providing functional magnetic resonance imaging data comparison services, comprising:

a means for receiving from a client via a communications network a client data set containing information related to a functional magnetic resonance image;

a means for identifying a plurality of spatially independent components related to the client data set by applying a blind source separation algorithm to the client data set; and

a means for receiving from the client a request to compare the plurality of independent components to a set of fundamental independent components in a database, the set of fundamental independent components comprising common components which exist in a scientifically-significant portion of a plurality of sets of independent components corresponding to a plurality of functional magnetic resonance image data sets contained in the database.

45. A system for providing functional magnetic resonance imaging data analysis services, comprising:

an interface adapted to receive from a client via a communications network a data set containing information related to a functional magnetic resonance image of an individual'"'"'s brain and adapted to deliver to the client information related to a plurality of spatially independent components related to the data set; and

a processing engine programmed to identify a plurality of spatially independent components related to the data set by applying a blind source separation algorithm to the data set.

53. A system for providing functional magnetic resonance imaging data analysis and comparison services, comprising:

an interface adapted to receive from a client via a communications network a client data set containing information related to a functional magnetic resonance image;

a processing engine programmed to identify a plurality of spatially independent components related to the client data set by applying a blind source separation algorithm to the client data set; and

a searchable database containing information related to (i) a plurality of sets of independent components corresponding to a plurality of functional magnetic resonance image data sets and (ii) a set of fundamental independent components comprising common independent components which exist in a scientifically-significant portion of the plurality of sets of independent components.

54. The system of claim 53, further comprising a functional magnetic resonance image comparison engine programmed to compare the plurality of independent components related to the client data set to the set of fundamental independent components in the database.

55. The system of claim 54, wherein the interface is coupled to the comparison engine and is adapted to deliver to the client information based on the comparison via the communications network.

56. The system of claim 53, wherein the processing engine is further programmed to reduce the dimensionality of the client data set by applying a singular value decomposition algorithm to the client data set prior to identifying spatially independent components of the client data set.

57. The system of claim 55, further comprising a billing functionality coupled to the interface for charging the client for delivering the information based on the comparison.

58. The system of claim 55, wherein the communications network is the Internet and the interface is a web server.

59. The system of claim 53, wherein the set of fundamental independent components in the database is modified based on the plurality of independent components related to the client data set.

60. A computer-readable medium for use by a computer for providing functional magnetic resonance imaging data analysis services, comprising:

a first portion of code for receiving from a client via a communications network a data set containing information related to a functional magnetic resonance image of an individual'"'"'s brain;

a second portion of code for identifying a plurality of spatially independent components related to the data set by applying a blind source separation algorithm to the data set; and

a third portion of code for delivering to the client via a communications network information related to the plurality of independent components of the data set.

61. The computer-readable medium of claim 60, further comprising a fourth portion of code for reducing the dimensionality of the data set by applying a singular value decomposition algorithm to the data set prior to identifying spatially independent components of the data set.

62. The computer-readable medium of claim 60, further comprising a fourth portion of code for charging the client for delivering the independent components of the data set.

63. The computer-readable medium of claim 60, wherein receiving from the client and delivering to the client is via the Internet and the client views the information related to the plurality of independent components of the data set with a web browser.

64. The computer-readable medium of claim 60, further comprising a fourth portion of code for storing the plurality of independent components in a database containing information related to a plurality of sets of other independent components, each set of other independent components corresponding to another data set related to a distinct functional magnetic resonance image of another individual'"'"'s brain.

65. The method of claim 60, further comprising a fourth portion of code for receiving a request from the client via the communications network to compare the plurality of independent components to the plurality of sets of other independent components in the database.

66. The computer-readable medium of claim 65, further comprising a fifth portion of code for (i) comparing the plurality of independent components to the plurality of sets of independent components in the database and (ii) delivering to the client via the communications network information based on the comparison.

67. The computer-readable medium of claim 66, further comprising a sixth portion of code for charging the client for delivering the information based on the comparison.

69. The computer-readable medium of claim 68, further comprising a fourth portion of code for comparing the plurality of independent components related to the client data set to the set of fundamental independent components in the database.

70. The computer-readable medium of claim 69, further comprising a fifth portion of code for delivering to the client information based on the comparison via the communications network.

71. The computer-readable medium of claim 68, further comprising a fourth portion of code for reducing the dimensionality of the client data set by applying a singular value decomposition algorithm to the client data set prior to identifying spatially independent components of the client data set.

72. The method of claim 70, further comprising a sixth portion of code for charging the client for delivering the information based on the comparison.

73. The computer-readable medium of claim 70, wherein receiving from a client and delivering to the client is via the Internet and the client views the information with a web browser.

74. The computer-readable medium of claim 69, further comprising a fifth portion of code for modifying the set of fundamental independent components in the database based on the plurality of independent components related to the client data set.

68. A computer-readable medium for use by a computer for providing functional magnetic resonance imaging comparison services, comprising:

a first portion of code for receiving from a client via a communications network a client data set containing information related to a functional magnetic resonance image;

a second portion of code for identifying a plurality of spatially independent components related to the client data set by applying a blind source separation algorithm to the client data set; and

a third portion of code for receiving from the client a request to compare the plurality of independent components to a set of fundamental independent components in a database, the set of fundamental independent components comprising common components which exist in a scientifically-significant portion of a plurality of sets of independent components corresponding to a plurality of functional magnetic resonance image data sets contained in the database.