Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
First Claim
1. A dual phase polymeric agent-delivery composition comprising:
- (a) a continuous biocompatible gel phase, (b) a discontinuous particulate phase comprising defined microparticles; and
(c) an agent to be delivered contained in at least said discontinuous particulate phase.
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Abstract
A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent—delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bioactive agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.
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Citations
54 Claims
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1. A dual phase polymeric agent-delivery composition comprising:
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(a) a continuous biocompatible gel phase, (b) a discontinuous particulate phase comprising defined microparticles; and
(c) an agent to be delivered contained in at least said discontinuous particulate phase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 48, 51, 52, 53, 54)
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22. A dual phase polymeric agent-delivery composition comprising:
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(a) a continuous biocompatible gel phase which is stimuli responsive, (b) a discontinuous particulate phase comprising defined microparticles; and
(c) an agent to be delivered contained in at least said discontinuous particulate phase. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 40, 42, 43, 44, 45, 46, 47, 49, 50)
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35. A dual phase polymeric agent-delivery composition comprising:
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(a) a continuous biocompatible gel phase having reverse thermal gelation properties, (b) a discontinuous particulate phase comprising defined microparticles; and
(c) an agent to be delivered contained in at least said discontinuous particulate phase.
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Specification