Detection system for disk-based laboratory and improved optical bio-disc including same
First Claim
1. A detection system for use in an optical disk-based analytical devise for measuring the presence of an analyte in a sample, said detection system comprising:
- an analyte detector unit comprising a primary detector which selectively reacts with analyte present in a sample to produce an amplification agent;
an amplification unit comprising a plurality of secondary detection agents wherein each of said detection agents is changeable between a negative detection state and a positive detection state; and
a fluid connection between said analyte detector unit and said amplification unit to provide reactive contact between said amplification agent and said plurality of detection agents wherein said amplification agent is capable of changing a plurality of said detection agents between said negative and said positive detection states to thereby amplify the measurable presence of said analyte.
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Abstract
A detection system for use in optical disk-based devices for measuring the presence of an analyte in a sample. The detection system includes an analyte detector unit containing a primary detector which selectively reacts with analyte present in a sample to produce an amplification agent. The detection system further includes an amplification unit comprising a plurality of secondary detection agents which are each changeable between a negative and positive detection state. A fluid connection is provided between the analyte detector unit and amplification unit to provide reactive contact between the amplification agent and the plurality of detection agents. The amplification agent is capable of changing a plurality of detection agents between the negative and positive detection states to thereby amplify the measurable presence of the analyte.
30 Citations
12 Claims
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1. A detection system for use in an optical disk-based analytical devise for measuring the presence of an analyte in a sample, said detection system comprising:
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an analyte detector unit comprising a primary detector which selectively reacts with analyte present in a sample to produce an amplification agent;
an amplification unit comprising a plurality of secondary detection agents wherein each of said detection agents is changeable between a negative detection state and a positive detection state; and
a fluid connection between said analyte detector unit and said amplification unit to provide reactive contact between said amplification agent and said plurality of detection agents wherein said amplification agent is capable of changing a plurality of said detection agents between said negative and said positive detection states to thereby amplify the measurable presence of said analyte. - View Dependent Claims (2, 3, 4, 5, 9, 10)
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6. A detection system for use in an optical disk-based analytical device for measuring the presence of an analyte in a sample, said detection system comprising:
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an analyte detector unit comprising a primary detector which selectively reacts with analyte present in a sample to produce a primary amplification agent;
a multiplier unit which comprises a plurality of intermediary multiplier agents;
a fluid connection between said analyte detector unit and said multiplier unit to provide reactive contact between said primary amplification agent and said plurality of intermediary multiplier agents wherein said primary amplification agent is capable of reacting with a plurality of said intermediary multiplier agents to provide a plurality of secondary amplification agents;
an amplification unit comprising a plurality of detection agents wherein each of said detection agents is changeable between a negative detection state and a positive detection state; and
a fluid connection between said multiplier unit and said amplification unit to provide reactive contact between said plurality of secondary amplification agents and said plurality of detection agents wherein each of said secondary amplification agents is capable of changing a plurality of said detection agents between said positive and said negative detection states to thereby amplify the measurable presence of said analyte. - View Dependent Claims (7, 8, 11, 12)
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Specification