Methods for diagnosing thyroid conditions and for monitoring thyroxine therapy
First Claim
1. A method of diagnosing a thyroid condition in a subject which comprises:
- a) obtaining a suitable urine sample from the subject;
b) determining the concentration of thyroid stimulating hormone in the sample by a method which is not a radioimmunoassay; and
c) comparing the concentration of thyroid stimulating hormone with a urinary concentration of thyroid stimulating hormone in a normal subject;
wherein;
i) a concentration of thyroid stimulating hormone which is higher than the urinary concentration of thyroid stimulating hormone in the normal subject diagnoses hypothyroidism in the subject; and
ii) a concentration of thyroid stimulating hormone which is lower than the urinary concentration of thyroid stimulating hormone in the normal subject diagnoses hyperthyroidism in the subject.
1 Assignment
0 Petitions
Accused Products
Abstract
This invention provides a method of diagnosing a thyroid condition in a subject which comprises: determining the concentration of thyroid stimulating hormone in a urine sample by a method which is not a radioimmunoassay; and comparing the concentration of thyroid stimulating hormone with a urinary concentration of thyroid stimulating hormone in a normal subject; wherein: i) a concentration of thyroid stimulating hormone which is higher than the urinary concentration of thyroid stimulating hormone in the normal subject diagnoses hypothyroidism in the subject; and ii) a concentration of thyroid stimulating hormone which is lower than the urinary concentration of thyroid stimulating hormone in the normal subject diagnoses hyperthyroidism in the subject. This invention also proves a method of monitoring thyroxine therapy.
9 Citations
93 Claims
-
1. A method of diagnosing a thyroid condition in a subject which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of thyroid stimulating hormone in the sample by a method which is not a radioimmunoassay; and
c) comparing the concentration of thyroid stimulating hormone with a urinary concentration of thyroid stimulating hormone in a normal subject;
wherein;
i) a concentration of thyroid stimulating hormone which is higher than the urinary concentration of thyroid stimulating hormone in the normal subject diagnoses hypothyroidism in the subject; and
ii) a concentration of thyroid stimulating hormone which is lower than the urinary concentration of thyroid stimulating hormone in the normal subject diagnoses hyperthyroidism in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 91, 92)
-
-
9. A method of diagnosing a thyroid condition in a subject which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of triiodothyronine in the sample by a method which is not a radioimmunoassay; and
c) comparing the concentration of triiodothyronine with a urinary concentration of triiodothyronine in a normal subject;
whereini) a concentration of triiodothyronine which is lower than the urinary concentration of triiodothyronine in the normal subject diagnoses hypothyroidism in the subject; and
ii) a concentration of triiodothyronine which is higher than the urinary concentration of triiodothyronine in the normal subject diagnoses hyperthyroidism in the subject. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28, 29, 30, 31, 32, 89, 93)
-
-
17. A method of diagnosing a thyroid condition in a subject which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of triiodothyronine-sulfate in the sample by a method which is not a radioimmunoassay; and
c) comparing the concentration of triiodothyronine-sulfate with a urinary concentration of triiodothyronine-sulfate in a normal subject;
whereini) a concentration of triiodothyronine-sulfate which is lower than the urinary concentration of triiodothyronine-sulfate in the normal subject diagnoses hypothyroidism in the subject; and
ii) a concentration of triiodothyronine-sulfate which is higher than the urinary concentration of triiodothyronine-sulfate in the normal subject diagnoses hyperthyroidism in the subject.
-
-
25. A method of diagnosing a thyroid condition in a subject which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of thyroxine present in the sample by a method which is not a radioimmunoassay;
c) comparing the concentration of thyroxine with a urinary concentration of thyroxine in a normal subject;
whereini) a concentration of thyroxine which is lower than the concentration of thyroxine in the normal subject diagnoses hypothyroidism in the subject; and
ii) a concentration of thyroxine which is higher than the urinary concentration of thyroxine in the normal subject diagnoses hyperthyroidism in the subject.
-
-
33. A method of diagnosing a thyroid condition in a subject which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of thyroxine-glucuronide present in the sample by a method which is not a radioimmunoassay;
c) comparing the concentration of thyroxine-glucuronide with a urinary concentration of thyroxine-glucuronide in a normal subject;
whereini) a concentration of thyroxine-glucuronide which is lower than the concentration of thyroxine-glucuronide in the normal subject diagnoses hypothyroidism in the subject; and
ii) a concentration of thyroxine-glucuronide which is higher than the urinary concentration of thyroxine-glucuronide in the normal subject diagnoses hyperthyroidism in the subject. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40)
-
-
41. A method of diagnosing a thyroid condition in a subject which comprises:
-
(2) obtaining a suitable urine sample from the subject;
b) determining the concentration of thyroid stimulating hormone and the concentration of triiodothyronine in the sample by a method which is not a radioimmunoassay;
c) comparing the concentration of thyroid stimulating hormone with a urinary concentration of thyroid stimulating hormone in a normal subject and comparing the concentration of triiodothyronine with a urinary concentration of triiodothyronine in a normal subject;
whereini) a concentration of thyroid stimulating hormone which is higher than the urinary concentration of thyroid stimulating hormone in the normal subject, and a concentration of triiodothyronine which is lower than the urinary concentration of triiodothyronine in the normal subject, diagnoses hypothyroidism in the subject; and
ii) a concentration of thyroid stimulating hormone which is lower than the urinary concentration of thyroid stimulating hormone present in the normal subject, and a concentration of triiodothyronine which is higher than the urinary concentration of triiodothyronine in the normal subject, diagnoses hyperthyroidism in the subject. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 55, 56, 57, 58, 59)
-
-
54. A method of diagnosing a thyroid condition in a subject which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of thyroid stimulating hormone and the concentration of thyroxine in the sample by a method which is not a radioimmunoassay;
c) comparing the concentration of thyroid stimulating hormone with a urinary concentration of thyroid stimulating hormone in a normal subject and comparing the concentration of thyroxine with a urinary concentration of thyroxine in a normal subject;
whereini) a concentration of thyroid stimulating hormone which is higher than the urinary concentration of thyroid stimulating hormone in a normal subject, and a concentration of thyroxine which is lower than the urinary concentration of thyroxine in a normal subject, diagnoses hypothyroidism in the subject; and
ii) a concentration of thyroid stimulating hormone which is lower than the urinary concentration of thyroid stimulating hormone in a normal subject, and a concentration of thyroxine which is higher than the urinary concentration of thyroxine in a normal subject, diagnoses hyperthyroidism in the subject. - View Dependent Claims (60, 61, 62, 63, 64, 65, 66, 68, 69, 70, 71, 72, 73)
-
-
67. A method of determining whether a subject being treated with thyroxine is receiving a proper dosage of thyroxine which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of thyroid stimulating hormone in the sample by a method which is not a radioimmunoassay; and
c) comparing the concentration of thyroid stimulating hormone with a urinary concentration of thyroid stimulating hormone in a normal subject;
wherein a concentration of thyroid stimulating hormone which is higher or lower than the urinary concentration of thyroid stimulating hormone in a normal subject indicates that the subject is not receiving the proper dosage of thyroxine. - View Dependent Claims (88, 90)
-
-
74. A method of determining whether a subject being treated with thyroxine is receiving a proper dosage of thyroxine which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of triiodothyronine in the sample by a method which is not a radioimmunoassay; and
c) comparing the concentration of triiodothyronine with a urinary concentration of triiodothyronine in a normal subject;
wherein a concentration of triiodothyronine which is higher or lower than the urinary concentration of triiodothyronine in a normal subject indicates that the subject is not receiving the proper dosage of thyroxine. - View Dependent Claims (75, 76, 77, 78, 79, 80)
-
-
81. A method of determining whether a subject being treated with thyroxine is receiving a proper dosage of thyroxine which comprises:
-
a) obtaining a suitable urine sample from the subject;
b) determining the concentration of thyroxine in the sample by a method which is not a radioimmunoassay;
c) comparing the concentration of thyroxine with a urinary concentration of thyroxine in a normal subject;
wherein a concentration of thyroxine which is higher or lower than the urinary concentration of thyroxine in a normal subject indicates that the subject is not receiving the proper dosage of thyroxine. - View Dependent Claims (82, 83, 84, 85, 86, 87)
-
Specification