Polymeric heart valve fabricated from polyurethane/polysiliconeurethane blends

• US 20020082689A1
• Filed: 12/21/2000
• Published: 06/27/2002
• Est. Priority Date: 12/21/2000
• Status: Active Grant

• Current Assignee: Corcym SRL (LivaNova Plc)
• Original Assignee: Joseph Andrew Chinn
• Inventors: Chinn, Joseph Andrew
• Granted Patent: US 6,596,024 B2
• Time in Patent Office: Days
• US Class Current: 623/2.17
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10S 623/926 Synthetic

Abstract

Biocompatible prostheses, specifically, biocompatible heart valves, are described which comprise a blend of a polyurethane (PU) and a polysiliconeurethane (PSU). Preferably, the polyurethane is a polyetherurethane (PEU). More preferably, it is a polyetherurethane urea (PEUU). Such prostheses typically exhibit reduced mineralization or thrombosis and/or reduced biological degradation.

Claims

1. A biocompatible heart valve prosthesis, comprising:

a valve body comprising a blood flow orifice;

at least one polymeric leaflet coupled to said valve body, said leaflet comprising a blend of a polyurethane (PU) and a polysiliconeurethane (PSU).

2. The biocompatible prosthesis of claim 1, wherein the polyurethane is selected from polyetherurethane (PEU), polyetherurethane urea (PEUU), or polycarbonateurethane (PCU).

3. The biocompatible prosthesis of claim 1, wherein the polysiliconeurethane is selected from polysiliconeurethane (PSU), polysiliconeurethane/polyetherurethane (PSU/PEU) copolymer, or polysiliconeurethane/polycarbonateurethane (PSU/PCU) copolymer.

4. The biocompatible prosthesis of claim 1, wherein the weight ratio of PU:

PSU in the blend is from about 1;

99 to about 9;

1.

5. The biocompatible prosthesis of claim 4, wherein the weight ratio of PU:

PSU in the blend is from about 1;

5 to about 1;

1.

6. The biocompatible prosthesis of claim 1, wherein the prosthesis is a heart valve comprising a stent defining a blood flow path, and a plurality of polymeric leaflets comprising a blend of PU and PSU.

7. A method of reducing mineralization, thrombosis, or biological degradation of an implanted prosthesis, comprising:

prior to implantation, fabricating at least a portion of the prosthesis from a blend of a polyurethane (PU) and a polysiliconeurethane (PSU); and

,

implanting the prosthesis.

8. The method of claim 7, wherein the polyurethane is selected from polyetherurethane (PEU), polyetherurethane urea (PEUU), or polycarbonateurethane (PCU).

9. The method of claim 7, wherein the polysiliconeurethane is selected from polysiliconeurethane (PSU), polysiliconeurethane/polyetherurethane (PSU/PEU) copolymer, or polysiliconeurethane/polycarbonateurethane (PSU/PCU) copolymer.

10. The method of claim 7, wherein the weight ratio of PU:

PSU in the blend is from about 1;

99 to about 9;

1.

11. The method of claim 10, wherein the weight ratio of PU:

PSU in the blend is from about 1;

5 to about 1;

1.

12. The method of claim 7, wherein the prosthesis is a heart valve comprising a stent defining a blood flow path, and a plurality of polymeric leaflets comprising a blend of PU and PSU.