Method for determining the prognosis of a patient with a neurological disease
First Claim
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1. A method of determining the prognosis for a patient already diagnosed with a non-AD neurological disease, said method comprising:
- a) identifying a patient with said disease;
b) determining the apoE genotype or phenotype of said patient;
c) converting the data obtained in step b) into a prognosis for said patient.
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Abstract
The present invention provides a method for the determining the prognosis for a patient diagnosed with a neurological disease. The present invention also provides a method for the identification of human subjects for placement in clinical drug trials of drugs being tested for the treatment of neurological disease and for determining a patient'"'"'s future disease risk.
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Citations
27 Claims
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1. A method of determining the prognosis for a patient already diagnosed with a non-AD neurological disease, said method comprising:
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a) identifying a patient with said disease;
b) determining the apoE genotype or phenotype of said patient;
c) converting the data obtained in step b) into a prognosis for said patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13, 14, 15, 16, 18, 19, 20, 21, 22, 23, 25, 26, 27)
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12. A method for identifying a patient for participation in a clinical trail of a drug for the treatment of a neurological disease, said method compromising:
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a) identifying a patient already diagnosed with said disease or as being predisposed to acquire or be at risk for said disease;
b) determining the apoE genotype or phenotype of said patient;
c) converting the data obtained in step b) and determining the prognosis of said patient, said prognosis including a prediction of whether the patient is a candidate for a drug trial for the treatment of a neurological disease.
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17. A method of determining a prognosis of future risk of a disease for a mammal asymptomatic for said disease, said method comprising:
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a) determining the apoE genotype or phenotype of said mammal;
b) converting the data obtained in step a) into a prognosis for said human, said prognosis including a prediction of a human'"'"'s future disease risk, drug treatment efficacy for said disease, or treatment outcome.
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24. A kit for determining a prognosis, said kit including a means for converting the patient profile into a prognosis.
Specification