Methods, systems, and computer program products for analyzing and presenting NMR lipoprotein-based risk assessment results
First Claim
1. A computer program product for automatically generating personalized lipoprotein-based information for a plurality of subjects, the computer program product comprising:
- a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating lipoprotein measurement values for a patient'"'"'s blood and/or plasma sample, the lipoprotein measurement values including a plurality of lipoprotein subclass variable measurements, including at least two of;
LDL size, LDL density or concentration, large HDL density or concentration, and large VLDL triglyceride density or concentration;
computer readable program code for comparing the plurality of patient lipoprotein subclass variable values with respective predetermined test criteria for determining whether the subclass variable values are associated with a higher or lower risk of developing coronary heart disease; and
computer readable program code for automatically generating personalized lipoprotein-based reports for a plurality of patients, wherein the computer program code for generating the report includes computer program code for generating a plurality of risk analysis portions, one for each measured lipoprotein subclass, so that a respective one risk analysis portion is aligned adjacent the corresponding measured subclass lipoprotein value, each of the respective risk analysis portions visually indicating when there is a higher risk of coronary heart disease for the measured value to thereby provide a contemporaneous reference guideline for interpretation of the measured value.
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Accused Products
Abstract
A method for analyzing a patient'"'"'s risk of coronary heart disease by determining the presence of NMR-derived or based lipoprotein constituent value abnormalities includes determining the presence of atherogenic dyslipidemia based on the existence of a clustering of lipoprotein constituent abnormalities as defined by predetermined test criteria. Computer program products and automatically produced reports for presenting NMR-derived lipoprotein risk assessment based on patient-specific lipoprotein subclass results present the measurement results adjacent to a segmented reference risk analysis portion. The actual measured results are visually aligned and enhanced within the risk analysis portion to provide easy reference and understanding of the results relative to a risk of developing coronary heart disease.
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Citations
51 Claims
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1. A computer program product for automatically generating personalized lipoprotein-based information for a plurality of subjects, the computer program product comprising:
a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating lipoprotein measurement values for a patient'"'"'s blood and/or plasma sample, the lipoprotein measurement values including a plurality of lipoprotein subclass variable measurements, including at least two of;
LDL size, LDL density or concentration, large HDL density or concentration, and large VLDL triglyceride density or concentration;
computer readable program code for comparing the plurality of patient lipoprotein subclass variable values with respective predetermined test criteria for determining whether the subclass variable values are associated with a higher or lower risk of developing coronary heart disease; and
computer readable program code for automatically generating personalized lipoprotein-based reports for a plurality of patients, wherein the computer program code for generating the report includes computer program code for generating a plurality of risk analysis portions, one for each measured lipoprotein subclass, so that a respective one risk analysis portion is aligned adjacent the corresponding measured subclass lipoprotein value, each of the respective risk analysis portions visually indicating when there is a higher risk of coronary heart disease for the measured value to thereby provide a contemporaneous reference guideline for interpretation of the measured value. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A computer program product for providing patient specific NMR-measured lipoprotein information, the computer program product comprising:
a computer readable storage medium having computer readable program code means embodied in said medium, said computer-readable program code means comprising;
computer readable program code for obtaining NMR-measured measurements for a plurality of lipoprotein subclass constituents including at least LDL particle size, LDL concentration, and large HDL concentration;
computer readable program code for determining a coronary heart disease risk level associated with each of the plurality of NMR-measured lipoprotein subclass measurements; and
computer readable program code for automatically generating a lipoprotein report for a plurality of patients with data corresponding to patient specific NMR-measured lipoprotein subclasses, the computer readable program code for generating the reports including computer readable program code for generating, for each reported measured subclass value, an adjacently positioned associated risk analysis portion that visually indicates when there is an increased risk of coronary heart disease associated with the respective lipoprotein subclass measurement to thereby provide a contemporaneous reference guideline for interpretation of the measured lipoprotein subclass value. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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35. A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:
a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code for generating NMR-based lipoprotein measurement values for a patient'"'"'s blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values to determine the presence of a metabolic abnormality or atherogenic dyslipidemia; and
computer readable program code for assessing a patient'"'"'s risk of coronary heart disease based on the presence of at least one of an elevated LDL particle concentration and/or the metabolic abnormality or atherogenic dyslipidemia.
Specification