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Murine expression of a human IgA lambda locus

  • US 20020088016A1
  • Filed: 12/13/2000
  • Published: 07/04/2002
  • Est. Priority Date: 11/03/1998
  • Status: Active Grant
First Claim
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1. A transgenic mouse comprising as a translocus a YAC of about 410 Kb, wherein the YAC contains most of the human Vλ

  • genes of cluster A and all the human Jλ

    -Cλ

    segments in germline configuration, wherein the translocus shows high expression, and is able to compete equally with the endogenous mouse κ

    locus.

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