Methods of and pharmaceutical compositions for improving implantation of embryos
First Claim
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1. A method of improving embryo implantation, the method comprising contacting an embryo with an effective amount of heparanase and implanting the embryo in a receptive uterus.
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Abstract
Methods of improving embryo implantation are disclosed and comprise contacting a receptive uterus and/or an embryo with an effective amount of heparanase and implanting the embryo in the receptive uterus.
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Citations
50 Claims
- 1. A method of improving embryo implantation, the method comprising contacting an embryo with an effective amount of heparanase and implanting the embryo in a receptive uterus.
- 7. A method of improving embryo implantation, the method comprising contacting a receptive uterus with an effective amount of heparanase and implanting the embryo in the receptive uterus.
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13. A method of improving embryo implantation, the method comprising contacting a receptive uterus with an effective amount of heparanase, contacting an embryo with an effective amount of heparanase and implanting the embryo in the receptive uterus.
- 21. A method of improving IVF embryo implantation, the method comprising contacting an IVF embryo with an effective amount of heparanase and implanting the embryo in a receptive uterus.
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26. A method of improving IVF embryo implantation, the method comprising contacting a receptive uterus with an effective amount of heparanase and implanting the IVF embryo in the receptive uterus.
- 31. A method of improving IVF embryo implantation, the method comprising contacting a receptive uterus with an effective amount of heparanase, contacting an IVF embryo with an effective amount of heparanase and implanting the IVF embryo in the receptive uterus.
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38. An embryo coated with exogenous heparanase.
- 42. A pharmaceutical composition comprising, as an active ingredient, an effective amount of heparanase, the pharmaceutical composition is designed for intra-uterine application.
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45. A pharmaceutical composition comprising, as an active ingredient, an effective amount of heparanase, the pharmaceutical composition is designed for application to an embryo in vitro.
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48. An embryo growth composition comprising an effective amount of nutrients for embryonic growth and an effective amount of heparanase for assisting in embryo implantation.
Specification