Method and system for modeling biological systems
First Claim
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1. A method for storing multiple computational biological models, said method comprising:
- a. selecting a base model from a plurality of computational biological models;
b. computing an overlay for each computational biological model other than the base model;
c. storing said base model; and
d. storing said overlays.
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Abstract
The present invention relates to a method and system for quantitative and semi-quantitative modeling of biological and physiological systems. More specifically, the invention relates to the use of overlays to store and manipulate computational biological models. Also provided by the invention are methods and systems for preparing overlays, methods and systems for creating new computational biological models by applying overlays to old models, and computer program products comprising overlays.
81 Citations
59 Claims
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1. A method for storing multiple computational biological models, said method comprising:
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a. selecting a base model from a plurality of computational biological models;
b. computing an overlay for each computational biological model other than the base model;
c. storing said base model; and
d. storing said overlays. - View Dependent Claims (2, 3, 4, 5, 25, 26, 27, 59)
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6. A method for quantitative or semi-quantitative modeling of a biological or physiological system, said method comprising:
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a. applying one or more overlays to a base computational biological model to generate a second computational biological model; and
b. running a predictive simulation of said second computational biological model. - View Dependent Claims (8, 9, 10)
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7. A method for quantitative or semi-quantitative modeling of a biological or physiological system, said method comprising:
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a. retrieving a base computational biological model;
b. retrieving an overlay;
c. applying said overlay to said base model to generate a new computational biological model; and
d. running a simulation of said new model on a computer.
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11. A method for creating an overlay comprising:
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a. constructing a base computational biological model;
b. constructing a second computational biological model;
c. comparing the second model with the base model to ascertain the differences between the two models; and
d. computing an overlay based upon the differences between the two models. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 28, 29, 30)
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23. A method for creating an overlay comprising:
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a. obtaining information or data relevant to a base computational biological model; and
b. computing an overlay based upon the model changes implied by said information or data.
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31. An overlay incorporated in a computer readable medium comprising:
- means to operate on a computational biological model to introduce at least one change in said model.
- View Dependent Claims (32, 33, 35, 36, 37, 38)
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34. A system for storing multiple computational biological models, said system comprising:
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a. means for selecting a base model from a plurality of computational biological models;
b. means for computing an overlay for each computational biological model other than the base model;
c. means for storing said base model; and
d. means for storing said overlays.
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39. A system for quantitative or semi-quantitative modeling of a biological or physiological system, said system comprising:
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a. means for applying one or more overlays to a base computational biological model to generate a second computational biological model; and
b. means for simulating said second computational biological model. - View Dependent Claims (41, 42, 43)
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40. A system for quantitative or semi-quantitative modeling of a biological or physiological system, said system comprising:
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a. means for retrieving a base computational biological model;
b. means for retrieving an overlay;
c. means for applying said overlay to said base model to generate a new computational biological model; and
d. means for simulating said new model on a computer.
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44. A system for creating an overlay comprising:
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a. means for constructing a base computational biological model;
b. means for constructing a second computational biological model;
c. means for comparing the second model with the base model to ascertain the differences between the two models; and
d. means for computing an overlay based upon the differences between the two models. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 57)
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56. A system for creating an overlay comprising:
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a. means for obtaining information or data relevant to a base computational biological model; and
b. means for computing an overlay based upon the model changes implied by said information or data.
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58. A computer program product comprising at least one overlay stored in a computer usable media in a computer readable format.
Specification