Multiple data layer optical discs for detecting analytes

• US 20020097658A1
• Filed: 12/10/2001
• Published: 07/25/2002
• Est. Priority Date: 12/08/2000
• Status: Active Grant

• Current Assignee: Vindur Technologies, Inc.
• Original Assignee: Nagaoka & Co., Ltd.
• Inventors: Norton, James R., Ortiz, Victor M., Worthington, Mark O., Kido, Horacio
• Granted Patent: US 6,760,298 B2
• Time in Patent Office: Days
• US Class Current: 369/94
• CPC Class Codes: B01L 2300/021 Identification, e.g. bar codes
• CPC Class Codes: B01L 2300/0609 Holders integrated in container to position an object
• CPC Class Codes: B01L 2300/0806 Standardised forms, e.g. compact disc [CD] format
• CPC Class Codes: B01L 2400/0409 centrifugal forces
• CPC Class Codes: B01L 2400/06 Valves, specific forms thereof
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/545 for laboratory containers
• CPC Class Codes: G01N 21/07 Centrifugal type cuvettes G01N21/09 takes precedence
• CPC Class Codes: G01N 21/55 Specular reflectivity
• CPC Class Codes: G01N 21/59 Transmissivity G01N21/25 takes precedence
• CPC Class Codes: G01N 21/9506 Optical discs
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: G01N 35/00069 whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk

Abstract

This invention relates to optical discs that preferably include multiple data layers and are configured to receive analytes which can be detected by an optical disc reader. The optical disc reader may be a standard optical disc reader or an optical disc reader modified therefrom. The optical disc may include (1) a first layer including optically readable structures which have encoded tracking information, and speed information enabling an optical disc reader to rotate the optical disc at a speed that is determinable from the speed information; (2) a second layer including optically readable structures; and (3) an analyte section capable of receiving an analyte which can be read by the optical disc reader.

Claims

1. An optical disc, comprising at least:

a first layer including optically readable structures which have encoded tracking information, and speed information enabling an optical disc reader to rotate the optical disc at a speed that is determinable from said speed information;

a second layer including optically readable structures; and

an analyte section capable of receiving an analyte which can be read by the optical disc reader.

2. The optical disc according to claim 1 wherein the analyte section includes a first chamber, and at least part of the first chamber is within the optical disc.

3. The optical disc according to claim 2 wherein at least one of the first layer and the second layer contains a first channel connecting to the first chamber.

4. The optical disk according to claim 3 wherein the optical disc reader is a DVD reader or a CD reader.

5. The optical disc according to claim 3 wherein the first channel includes a valve which can be regulated by optically readable data encoded in the optical disc.

6. The optical disc according to claim 3 wherein the analyte section includes a second chamber, at least part of the second chamber being located within the optical disc, and at least one of the first layer and the second layer containing a second channel connecting to the second chamber.

7. The optical disc according to claim 2 wherein said optically readable structures in the first layer are impressed in a surface of the first layer and are coated with a first reflective layer, and said optically readable structures in the second layer are impressed in a surface of the second layer and are coated with a second reflective layer, the first reflective layer and the second reflective layer being located between the first layer and the second layer.

8. The optical disc according to claim 7 wherein the second reflective layer is semi-reflective.

9. The optical disc according to claim 7 wherein the first reflective surface is semi-reflective.

10. The optical disc according to claim 7 wherein the first chamber includes a surface which is located within 15 micrometers from either said surface of the first layer or said surface of the second layer.

11. The optical disc according to claim 10 wherein said surface of the first chamber holds the analyte.

12. The optical disc according to claim 7 wherein at least one of said surface of the first layer and said surface of the second layer includes an area which lacks optical readable structures that have encoded tracking information, and a surface of the first chamber includes said area.

13. The optical disc according to claim 7 wherein at least one of said surface of the first layer and said surface of the second layer includes an area which lacks reflective coatings, and a surface of the first chamber includes said area.

14. The optical disc according to claim 7 wherein said optically readable structures in the first layer or said optically readable structures in the second layer have encoded assay information for conducting an assay on the analyte.

15. The optical disc according to claim 14 wherein said optically readable structures in the first layer or said optically readable structures in the second layer have encoded focus control information enabling the optical disc reader to move the focal point of a reading beam in a manner determinable from said focus control information.

16. The optical disc according to claim 1 wherein at least one of the first layer and the second layer is a hologram.

17. The optical disc according to claim 16 wherein the optical disc reader is a CD or DVD reader.

18. The optical disc according to claim 16 wherein at least part of an image plane of the hologram is located with the analyte section.

19. The optical disc according to claim 16 wherein the analyte section includes a surface which is located within 15 micrometers from the image plane of the hologram.

20. The optical disc according to claim 19 wherein said surface of the analyte section is within the image plane of the hologram.

21. The optical disc according to claim 19 wherein said surface of the analyte section holds the analyte.

22. A method for detecting an analyte held in the analyte section of the optical disc of claim 1, comprising:

providing the optical disc to the optical disc reader;

reading the optical disc; and

obtaining at least one signal which is indicative of the presence of the analyte.

23. The method according to claim 22 wherein the optical disc reader includes at least two detectors, one detector being capable of generating tracking signals, and the other detector being capable of receiving radiation that passes through the optical disc and generating said signal which is indicative of the presence of the analyte.

24. An optical disc, comprising:

optically readable structures which have encoded tracking information, and speed information enabling an optical disc reader to rotate the optical disc at a speed that is determinable from said speed information; and

an analyte section capable of receiving an analyte which can be read by the optical disc reader.