Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
First Claim
1. An array for screening to identify conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state comprising at least 24 samples, each sample comprising a medium, wherein one or more of the samples comprises a disease-causing substance.
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Abstract
The invention concerns arrays comprising hundreds, thousands, to hundreds of thousands of samples and methods for screening thereof. These methods are useful to optimize, select, and discover compounds, compositions, or conditions that prevent, inhibit, induce, modify, or reverse physical-state transitions, particularly in-vivo physical-state transitions relating to disease causing processes. Such compounds, compositions, or conditions can be exploited to treat (e.g., reverse) or prevent the disease itself, the cause of the disease, or the symptoms of the disease.
67 Citations
80 Claims
- 1. An array for screening to identify conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state comprising at least 24 samples, each sample comprising a medium, wherein one or more of the samples comprises a disease-causing substance.
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15. A method of preparing an array of at least 24 samples for screening to identify conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state comprising:
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(a) adding a medium to each of the samples; and
(b) adding a disease-causing substance to at least one of the samples.
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29. A method of screening an array of at least 24 samples to identify conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state comprising:
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(a) preparing an array of at least 24 samples each sample comprising a medium and a disease-causing substance;
(b) processing one or more of the samples to induce or reverse the transition of physical-state in the disease causing substance; and
(c) analyzing the processed samples to detect the induction or reversal of the transition in physical state.
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51. A method to discover conditions, compounds, or compositions that prevent or inhibit crystallization, precipitation, polymerization, or deposition of a disease-causing substance, or promote depolymerization comprising:
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(a) preparing an array comprising at least 24 samples each sample comprising a medium and one or more components to induce a disease-causing substance;
(b) processing one or more of the samples to induce crystallization, precipitation, or deposition of the disease-causing substance;
(c) screening the array by analyzing the processed samples to detect the absence of crystallization, precipitation, polymerization, depolymerization, or deposition of the disease-causing substance; and
(d) selecting the samples wherein crystallization, precipitation, polymerization, depolymerization, or deposition of the disease-causing substance did not occur to identify the conditions, compounds, or compositions. - View Dependent Claims (52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
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66. A method to discover conditions, compounds or compositions that promote dissolution, destruction, or breakup of a disease-causing substance, comprising:
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(a) preparing an array comprising at least 24 samples each sample comprising a medium and the disease-causing substance;
(b) processing one or more of the samples to induce the dissolution, destruction, or breakup of the disease-causing substance;
(c) screening the array by analyzing the processed samples to detect the dissolution, destruction, depolymerization, or breakup of the disease-causing substance; and
(d) selecting the samples wherein the dissolution, destruction, depolymerization, or breakup of the disease-causing substance occurred to identify the conditions, compounds, or compositions. - View Dependent Claims (67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80)
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Specification