Method for tracking compounds in solution phase combinatorial chemistry

• US 20020098598A1
• Filed: 01/24/2002
• Published: 07/25/2002
• Est. Priority Date: 01/24/2001
• Status: Abandoned Application

• Current Assignee: NEXUS Biosystems, Inc. (Azenta, Inc.)
• Original Assignee: NEXUS Biosystems, Inc. (Azenta, Inc.)
• Inventors: Hu, Yi, Xiao, Xiao-Yi, Coffen, David L.
• Application Number:
  US10/056,257
• Publication Number:
  US 20020098598A1
• Time in Patent Office: Days
• US Class Current: 506/27
• CPC Class Codes: C07C 231/02 from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
• CPC Class Codes: C07C 233/07 having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
• CPC Class Codes: C07D 471/10 Spiro-condensed systems
• CPC Class Codes: C40B 40/04 Libraries containing only organic compounds
• CPC Class Codes: C40B 50/08 Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support

Abstract

A method for the generation of chemical libraries using machine-readable passive tagging systems is described. The preferred embodiment uses radiofrequency tags or one- or two-dimensional bar codes to track vials and the contents therein throughout the course of the synthesis. This abrogates the need for specialized combinatorial chemistry equipment, allowing the use of standard laboratory baths, ovens, shakers and racks, as well as manual fluid handling techniques.

Claims

1. A method for producing combinatorial chemical libraries using solution phase combinatorial chemistry comprising labeling vials with unique, machine readable tags, performing at least two chemical reactions and tracking the reactions using the machine readable tags.

2. A method as in claim 1, wherein the machine readable tags comprise radiofrequency (Rf) encoded transponders.

3. A method as in claim 1, wherein the machine readable tags comprise one- and two-dimensional bar codes.

4. A method as in claim 1, wherein the reactions comprise a chemical synthesis plan.

5. A method as in claim 1, wherein machine readable tags encode information links which relate to each individual container and its contents to a specific compound in the chemical synthesis plan.

6. A method as in claim 1, wherein machine readable tags guide machines and automation devices employed for tracking, sorting and manipulating individual containers throughout the synthesis plan.