Method and apparatus to remove substances from vessels of the heart and other parts of the body to minimize or aviod renal or other harm or dysfunction
First Claim
1. An apparatus for removing contrast from the coronary sinus during angiographic and coronary intervention procedures to substantially prevent the contrast from entering systemic circulation, comprising:
- a catheter having a balloon tip to selectively occlude said vascular circulation to thereby temporarily retain said contrast in a selected portion of vascular circulation upstream of said coronary sinus;
a suction device to selectively remove said contrast from said vascular circulation while temporarily retained in said selected portion of said vascular circulation; and
a controller to stop said suction device when at least a predetermined amount of said contrast has been removed from said vascular circulation.
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Accused Products
Abstract
To accomplish isolation and removal of a substance from a vasculature, a catheter is employed to occlude a vessel of the vasculature. The substance is thus isolated in the vasculature and can be removed. In this way, the substance is removed before entering other parts of the circulatory system. This method is applicable to removal of contrast from the coronary sinus shortly after injection of the coronary arteries with the contrast. The method substantially minimizes or avoids renal dysfunction caused by angiographic procedures in which contrast must be injected. Such angiographic procedures are often performed during intervention procedures. This method substantially prevents circulation of the contrast to the kidneys where it could otherwise cause renal dysfunction or failure. The apparatus for implementation of the method is also disclosed.
68 Citations
53 Claims
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1. An apparatus for removing contrast from the coronary sinus during angiographic and coronary intervention procedures to substantially prevent the contrast from entering systemic circulation, comprising:
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a catheter having a balloon tip to selectively occlude said vascular circulation to thereby temporarily retain said contrast in a selected portion of vascular circulation upstream of said coronary sinus;
a suction device to selectively remove said contrast from said vascular circulation while temporarily retained in said selected portion of said vascular circulation; and
a controller to stop said suction device when at least a predetermined amount of said contrast has been removed from said vascular circulation.
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2. A method for minimizing renal failure due to contrast injected in at least one vessels of the heart during angiographic and coronary intervention procedures, comprising:
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disposing a catheter having a balloon tip through a femoral vein and into a selected portion of said at least one vessel;
inflating said balloon tip to selectively form an occlusion in said at least one vessel to thereby temporarily retain said contrast in said selected portion upstream of said occlusion of said at least one vessel; and
removing at least a portion of said contrast from said at least one vessel while said contrast is temporarily retained in said selected portion of said at least one vessel until a predetermined concentration of said contrast in said vascular system is realized.
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3. An apparatus for occluding a coronary sinus vein and removing contrast from blood upstream of an occluded portion of said coronary sinus vein before permitting a remnant of said contrast to enter body circulatory systems via said blood, said apparatus comprising:
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a catheter having;
a balloon tip on one end for insertion into and occlusion of said vein, said balloon tip comprising a bend; and
a suction device for removing said contrast by suctioning through said catheter; and
a controller for starting and stopping said suction device at specific times. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 37, 38, 39, 40, 41, 42, 43)
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17. A method of isolating a substance in a vessel and a volume of a heart and of removing said substance in blood from said vessel and said volume of said heart during angiographic and coronary intervention procedures to lower an amount of said substance that is permitted to enter said heart and systemic circulation of the body, said method comprising:
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inserting a first catheter having a bend on a distal end through a natural via of said body to said vessel, wherein said first catheter has a means for occluding;
inserting a second catheter through another natural via of said body to a location upstream of said vessel;
injecting said substance into said location upstream of said vessel;
forming an occlusion in said vessel by said means for occluding of said first catheter;
suctioning said blood and said substance from said vessel upstream of said occlusion; and
removing said occlusion after a majority of said substance has been suctioned out of said vessel.
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36. A method of injecting a substance into and removing a substance from a blood vessel of a human body as a primary or a secondary procedure, wherein said substance stays in said vessel temporarily and is removed during said procedure to avoid harmful effects by said substance on said human body, said method comprising the steps of:
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inserting a first balloon tip catheter percutaneously into said vessel;
inserting a second catheter percutaneously into a volume in fluid communication with said vessel;
occluding said vessel by a means for occluding on an end of said first catheter;
injecting said substance in said volume for natural flow toward said vessel;
suctioning said substance in said volume and said vessel by a lumen in said first catheter through an orifice in said catheter distal to said means for occluding; and
coordinating the steps of the method by a controller connected to said catheters.
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44. A system for removing a substance that has been injected into the vasculature of a human or veterinary patient, said system comprising:
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a catheter having an expandable region that, when in an expanded state, will occlude a selected region of the vasculature to retain the substance in that region of the vasculature;
a suction device to remove at least a substantial portion of the injected substance from the region of the vasculature within which the substance has been retained; and
control apparatus to stop said suction device when at least a predetermined amount of the injected substance had been suctioned from the region of the vasculature within which the substance has been retained. - View Dependent Claims (47, 48, 49, 50)
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45. A method for minimizing renal damage resulting from introduction of a substance that causes renal damage into the vasculature of a mammalian patient, the method comprising the steps of:
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disposing a catheter having a balloon tip in a selected portion of said vascular system;
inflating said balloon tip to selectively occlude said vascular system to thereby temporarily retain said contrast in said selected portion of said vascular system; and
removing at least a portion said contrast from said vascular system while said contrast is temporarily retained in said selected portion of said vascular system until a predetermined concentration of said contrast in said vascular system is realized.
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46. An apparatus for removing a quantity of an injected substance from an anatomical vessel within the body of a mammalian patient, said apparatus comprising:
a catheter having;
an occluder for occluding the vessel;
a suction device for removing the injected substance from the vessel upstream of the occlusion created by the occluder; and
,a controller for starting and stopping said suction device at specific times.
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51. A method of isolating and removing at least a portion of a quantity of radiographic contrast medium that has been injected into the vasculature of a human or veterinary patient, said method comprising:
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A) inserting a first catheter having an occluder into a vessel to be occluded;
B) inserting a second catheter to a location upstream of the occluder;
C) injecting contrast into the patient'"'"'s vasculature upstream of the occluder;
D) causing the occluder to occlude the vessel such that at least a portion of the injected contrast medium is retained upstream of the occluder;
E) suctioning and removing from the vasculature at least a portion of the contrast medium that is retained upstream of the occluder; and
F) causing the occluder to cease occlusion of said vessel. - View Dependent Claims (52, 53)
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Specification