Platelet collecting apparatus

• US 20020099319A1
• Filed: 11/28/2001
• Published: 07/25/2002
• Est. Priority Date: 11/28/2000
• Status: Active Grant

• Current Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Original Assignee: Terumo Kabushiki Kaisha (Terumo Corporation)
• Inventors: Udagawa, Takeshi, Saito, Noboru, Horiuchi, Kunio
• Granted Patent: US 6,893,412 B2
• Time in Patent Office: Days
• US Class Current: 604/6.04
• CPC Class Codes: A61M 1/303 having a reservoir for treated blood to be returned
• CPC Class Codes: A61M 1/304 Treatment chamber used as reservoir, e.g. centrifuge bowl or filter with movable membrane
• CPC Class Codes: A61M 1/308 Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
• CPC Class Codes: A61M 1/36222 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/36225 with blood pumping means or components thereof
• CPC Class Codes: A61M 1/36226 Constructional details of cassettes, e.g. specific details on material or shape
• CPC Class Codes: A61M 1/362265 Details of valves
• CPC Class Codes: A61M 1/362266 Means for adding solutions or substances to the blood
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 2202/0014 removed from the body
• CPC Class Codes: A61M 2202/0415 Plasma
• CPC Class Codes: A61M 2202/0427 Platelets; Thrombocytes
• CPC Class Codes: A61M 2205/331 used as turbidity change detectors, e.g. for priming-blood or plasma-hemoglubine-interface detection
• CPC Class Codes: A61M 2205/3382 Upper level detectors
• CPC Class Codes: A61M 2205/50 with microprocessors or computers

Abstract

A platelet collecting apparatus 1 comprises a centrifugal separator 20 possessing a rotatable rotor 142; a first line 21 for allowing the flow of the blood entering the centrifugal separator 20; a second line 22 for allowing the flow of the blood emanating from the centrifugal separator, a plasma collecting bag 25 connected to the first line 21 and the second line 22 so as to collect the plasma emanating from the centrifugal separator 20 and return the collected plasma to the centrifugal separator 20, a platelet collecting bag 26 connected to the second line 22 so as to collect the platelets emanating from the centrifugal separator 20, a blood delivering pump 11 disposed in the first line 21, and a controller 13 for controlling the operation of the rotor of the centrifugal separator 20 and the operation of the blood delivering pump 11. The controller 13 is endowed with a function of varying the rotational frequency of the rotor 142 during the course of blood collection in conformity with the amount of the blood entered into the centrifugal separator 20 via the first line 21.

Claims

1. A platelet collecting apparatus comprising:

a centrifugal separator possessing a rotatable rotor having a blood storing space formed therein and an inlet and an outlet both communicating with said blood storing space and centrifugally separating the blood introduced through said inlet inside said blood storing space by virtue of the rotation of said rotor;

a first line for allowing the flow of the blood entering said centrifugal separator;

a second line for allowing the flow of the blood emanating from said centrifugal separator;

a plasma collecting bag connected to said first line and said second line so as to collect the plasma emanating from said centrifugal separator and return the collected plasma to said centrifugal separator;

a platelet collecting bag connected to said second line so as to collect the platelets emanating from said centrifugal separator;

a blood delivering pump disposed in said first line; and

a controller for controlling the operation of said rotor of said centrifugal separator and the operation of said blood delivering pump,

wherein said controller is endowed with a function of varying the rotational frequency of said rotor during the course of blood collection in conformity with the amount of the blood entered into said centrifugal separator via said first line.

2. A platelet collecting apparatus according to claim 1, wherein said controller is further furnished with a function of circulating the plasma collected in said plasma collecting bag as accelerated to said centrifugal separator and a function of varying the rotational frequency of said rotor in conformity with the speed of the circulation of said plasma caused by said function of accelerating circulation.

3. A platelet collecting apparatus according to claim 2, wherein said controller, while the plasma is circulated as accelerated by said function of accelerating circulation, increases the rotational frequency of said rotor in conformity with the increase of the flow rate of circulation produced by said blood delivering pump.

4. A platelet collecting apparatus according to any of claim 1, wherein said controller during the course of blood collection increases the rotational frequency of said rotor in conformity with the increase of the volume of erythrocytes in said centrifugal separator.

5. A platelet collecting apparatus according to any of claim 1, wherein said controller during the course of blood collection sequentially increases the rotational frequency of said rotor to a predetermined rotational frequency in conformity with the amount of the blood entered into said centrifugal separator.

6. A platelet collecting apparatus according to claim 1, which is further furnished with an input device for effecting entry of the hematocrit value and wherein said controller is furnished with a function of computing the rotational frequency of the rotor of said centrifugal separator at the end of the first round of blood collection based on the input of hematocrit value and said controller, during the course of blood collection, sequentially increases the rotational frequency of said rotor to the computed rotational frequency of said rotor in conformity with the amount of the blood entered into said centrifugal separator.

7. A platelet collecting apparatus according to claim 1, which is further furnished with a measuring device for measuring the hematocrit value and wherein said controller is furnished with a function of computing the rotational frequency of the rotor of said centrifugal separator at the end of the first round of blood collection based on the determined hematocrit value and said controller, during the course of blood collection, sequentially increases the rotational frequency of said rotor to the computed rotational frequency of said rotor in conformity with the amount of the blood entered into said centrifugal separator.

8. A platelet collecting apparatus according to claim 1, which is further furnished with a memory device for memorizing the amount of blood delivered per unit amount of operation of said blood delivering pump and a detecting device for detecting the amount of operation of said blood delivering pump and wherein said controller computes the amount of blood entered in said centrifugal separator based on the memorized amount of blood delivered per unit amount of operation and the detected amount of operation.

9. A platelet collecting apparatus according to claim 8, wherein said blood delivering pump is formed of a roller pump and said detecting device is formed of a means for detecting the amount of rotation of said roller pump.

10. A platelet collecting apparatus comprising:

a centrifugal separator possessing a rotatable rotor having a blood storing space formed therein and an inlet and an outlet both communicating with said blood storing space and centrifugally separating the blood introduced through said inlet inside said blood storing space by virtue of the rotation of said rotor;

a first line for allowing the flow of the blood entering said centrifugal separator;

a second line for allowing the flow of the blood emanating from said centrifugal separator;

a plasma collecting bag connected to said first line and said second line so as to collect the plasma emanating from said centrifugal separator and return the collected plasma to said centrifugal separator;

a platelet collecting bag connected to said second line so as to collect the platelets emanating from said centrifugal separator;

a blood delivering pump disposed in said first line; and

a controller for controlling the rotational frequency of said rotor of said centrifugal separator and the operation of said blood delivering pump,

wherein said controller is endowed with a function of circulating the plasma collected in said plasma collecting bag as accelerated to said centrifugal separator and a function of varying the rotational frequency of said rotor in conformity with the speed of the circulation of said plasma caused by said function of accelerating circulation.

11. A platelet collecting apparatus according to claim 10, wherein said controller, while the plasma is circulated as accelerated by said function of accelerating circulation, increases the rotational frequency of said rotor in conformity with the increase of the flow rate of circulation produced by said blood delivering pump.