Drug delivery system for implantable cardiac device

• US 20020099328A1
• Filed: 11/30/2001
• Published: 07/25/2002
• Est. Priority Date: 10/21/1999
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Girouard, Steven D., Scheiner, Avram, Heil, Ronald W. Jr., Herner, Mark
• Granted Patent: US 7,201,733 B2
• Time in Patent Office: Days
• US Class Current: 604/67
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
• CPC Class Codes: A61N 1/3621 for treating or preventing abnormally high heart rate
• CPC Class Codes: Y10S 128/12 Pressure infusion
• CPC Class Codes: Y10S 128/13 Infusion monitoring

Abstract

A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.

Claims

1. A drug delivery system comprising:

a cardiac device comprising a sensing channel for sensing electrical activity occurring in a patient'"'"'s heart and generating sensing signals in accordance therewith, circuitry for extracting information from the sensing signals, circuitry for detecting a particular medical condition from the extracted information and generating a command signal if the medical condition is present, a telemetry interface for receiving and transmitting radio frequency signals, and circuitry for modulating the radio frequency signals with information relating to the command signal; and

,

an external drug delivery device for affixation to a patient having incorporated therein a telemetry interface for receiving and transmitting radio frequency signals, circuitry for demodulating radio signals to derive a command signal therefrom, and circuitry for controlling the drug delivery device in order to deliver a drug in accordance with the command signal.

2. The system of claim 1 wherein the drug delivery device is an electrically modulated transdermal injector comprising:

a first electrode connected to a first drug reservoir for containing a drug and contacting a patient'"'"'s skin;

a second electrode for contacting a patient'"'"'s skin; and

,

a controllable power source for connecting to the electrodes and imposing a voltage therebetween.

3. The system of claim 2 wherein the cardiac device sends a command signal upon detection of a cardiac arrhythmia.

4. The system of claim 3 wherein the drug delivered is an antiarrhythmic.

5. The system of claim 2 wherein the cardiac device sends a command signal upon detection of myocardial ischemia.

6. The system of claim 5 wherein the drug delivered is selected from a group consisting of a vasodilator, a thrombolytic, an anti-platelet agent, an analgesic, and an anticoagulant.

7. The system of claim 2 wherein the medical condition detected is selected from a group consisting of hypotension and cardiac failure.

8. The system of claim 2 wherein the command signal is generated by the cardiac device.

9. The system of claim 2 wherein the command signal is generated by an external programmer.

10. The system of claim 2 wherein the external drug delivery device is configured to transmit a status signal back to the cardiac device after receipt of a command signal.

11. The system of claim 2 wherein the second electrode is connected to a second drug reservoir for simultaneously delivering drugs from both first and second reservoirs.

12. The system of claim 11 wherein the pH of a solution containing the drug in each reservoir is separately adjusted to be above or below the pK of the drug in accordance with the polarity of the electrode to which the reservoir is connected.

13. The system of claim 2 wherein the cardiac device is an implantable cardioverter/defibrillator having an output channel for delivering an electrical pulse to the heart upon detection of a fibrillation condition.

14. The system of claim 2 wherein the cardiac device is an implantable cardiac pacemaker having an output channel for pacing the heart.

16. The method of claim 15 wherein the drug delivery device delivers the drug by electrically modulated transdermal injection.

17. The method of claim 16 wherein the medical condition detected is a cardiac arrhythmia.

18. The method of claim 16 wherein the medical condition detected is myocardial ischemia.

19. The method of claim 16 wherein the drug delivered is selected from a group consisting of a thrombolytic, an analgesic, an anticoagulant, an anti-platelet agent, and a vasodilator in accordance with the command signal.

20. The method of claim 16 further comprising transmitting a status signal from the external drug delivery device after receipt of a command signal.

21. The method of claim 16 wherein the external drug delivery device delivers drugs in an amount in accordance with information contained in the command signal.

22. The method of claim 16 wherein the external drug delivery device delivers drugs over a period of time in accordance with information contained in the command signal.

23. The method of claim 16 wherein the external drug delivery device maintains downloadable logs of sensed electrical activity as transmitted to the drug delivery device by the cardiac device and of amounts of drugs administered by the drug delivery device.

15. A method for drug delivery comprising:

sensing electrical activity occurring in a patient'"'"'s heart with a cardiac device and generating sensing signals in accordance therewith;

extracting information from the sensing signals to detect whether a particular medical condition is present;

if the particular medical condition is present, transmitting a command signal to an external drug delivery device via a radio link; and

,

receiving the transmitted command signal with the drug delivery device and delivering a drug in accordance with the command signal.