Methods, circuits and compositions of matter for in vivo detection of biomolecule concentrations using fluorescent tags
First Claim
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1. A method for detecting biomolecules in vivo, the method comprising:
- providing labeled binding molecules in vivo to tissue having biomolecules, wherein the labeled binding molecules specifically binds the biomolecules;
emitting a first optical radiation into the tissue in vivo to excite the labeled binding molecule bound to the biomolecule in vivo; and
detecting, in vivo, a second optical radiation emitted by the excited labeled binding molecule in response to the excitation thereof.
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Abstract
Methods are disclosed wherein labeled antibodies can be provided in vivo to tissue having antigens that specifically bind the labeled antibody. A first optical radiation is emitted into the tissue in vivo to excite the labeled antibody bound to the antigen in vivo. A second optical radiation that is emitted by the excited labeled antibody, in response to the excitation thereof, can be detected in vivo. Related telemetric circuits and compositions of matter are also disclosed.
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Citations
22 Claims
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1. A method for detecting biomolecules in vivo, the method comprising:
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providing labeled binding molecules in vivo to tissue having biomolecules, wherein the labeled binding molecules specifically binds the biomolecules;
emitting a first optical radiation into the tissue in vivo to excite the labeled binding molecule bound to the biomolecule in vivo; and
detecting, in vivo, a second optical radiation emitted by the excited labeled binding molecule in response to the excitation thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A circuit for detecting biomolecules in vivo, the circuit comprising
an optical radiation source configured for in vivo use that emits first optical radiation; -
an optical radiation detector configured for in vivo use that detects second optical radiation emitted by excited labeled binding molecules; and
a processor circuit, coupled to the optical radiation source and the optical radiation detector, that controls the emission of the first optical radiation and that receives an intensity signal associated with the intensity of the second optical radiation and transmits a signal associated with the intensity of the second optical radiation to an ex vivo system. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22)
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18. A composition of matter comprising:
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labeled binding molecules that are excited by optical radiation; and
a material that encapsulates the labeled binding molecules which is dissolved over time to release the labeled binding molecules.
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Specification