Methods for treating a patient using a bioengineered flat sheet graft prostheses
First Claim
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1. A prosthesis comprising two or more superimposed, chemically bonded layers of processed tissue material which, when implanted into a mammalian patient, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient'"'"'s living cells.
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Abstract
This invention is directed to tissue engineered prostheses made from processed tissue matrices derived from native tissues that are biocompatible with the patient or host in which they are implanted. When implanted into a mammalian host, these prostheses can serve as a functioning repair, augmentation, or replacement body part or tissue structure.
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Citations
19 Claims
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1. A prosthesis comprising two or more superimposed, chemically bonded layers of processed tissue material which, when implanted into a mammalian patient, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient'"'"'s living cells.
- 2. A prosthesis comprising two or more superimposed, chemically bonded layers of processed tunica submucosa of small intestine which, when implanted into a mammalian patient, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient'"'"'s living cells.
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4. The method of preparing a bioremodelable prosthesis having two or more superimposed, bonded layers of processed tissue matrix, comprising:
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(a) layering two or more sheets of hydrated processed tissue layers;
(b) dehydrating said tissue layers to adhere the layers together;
(c) crosslinking said tissue layers with a crosslinking agent to bond the layers together; and
,(d) rinsing said layers to remove the crosslinking agent;
wherein the prosthesis, when implanted into a mammalian patient, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient'"'"'s living cells. - View Dependent Claims (5, 6)
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- 7. A method of repairing or replacing a damaged tissue comprising implanting a prosthesis in a patient comprising two or more superimposed, bonded layers of collagen material which, when implanted into a mammalian patient, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient'"'"'s living cells.
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9. A prosthesis comprising a single layer of processed intestinal tissue material derived from the small intestine submucosa used as a wound dressing.
- 10. A method for treating a damaged or diseased soft tissue in need of repair, comprising implantation of a prosthesis comprising two or more superimposed, chemically bonded layers of processed intestinal collagen derived from the tunica submucosa of small intestine which, when implanted on the damaged or diseased soft tissue, undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted prosthesis is remodeled by the patient'"'"'s living cells.
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13. A wound dressing comprising a sheet of processed intestinal collagen derived from the tunica submucosa of small intestine having a thickness between about 0.05 to about 0.07 mm which is biocompatible and bioremodelable.
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15. A method for treating a wound comprising applying a wound dressing construct comprising a sheet of processed intestinal collagen derived from the tunica submucosa of small intestine having a thickness between about 0.05 to about 0.07 mm which is biocompatible and bioremodelable, to a wound to treat the wound.
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17. A method for treating a hypermobile organ comprising implanting a surgical sling device comprising three to five layers of processed intestinal collagen derived from the tunica submucosa of small intestine which is bonded and crosslinked together with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride at a concentration between 0.1 to 100 mM.
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18. A surgical sling device for supporting hypermobile organs comprising three to five layers of processed intestinal collagen derived from the tunica submucosa of small intestine which is bonded and crosslinked together with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride at a concentration between 0.1 to 100 mM.
Specification