Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
First Claim
1. A method of making a drug delivery device, comprising the steps of:
- (a) preparing a coatable composition comprising one or more biodegradable polymeric materials, one or more pharmacologically active agents, and one or more biocompatible solvents;
(b) coating the composition to form a film;
(c) drying the coated film until the coated film can be formed into a cohesive body;
(d) forming said cohesive body; and
(e) compressing the cohesive body to form a drug delivery device.
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Abstract
The present invention relates to an improved method of making drug delivery devices for the controlled release of pharmacologically active agents and further, to drug delivery devices made by such method. More specifically, the present invention relates to a method of forming a film comprising one or more biodegradable polymeric materials, one or more pharmacologically active agents, and one or more biocompatible solvents. The film is then partially dried, rolled or otherwise shaped, and then compressed. In this manner, the amount of pharmacologically active agent(s) that can be incorporated into the drug delivery device is increased and the pharmacologically active agent(s) is/are substantially homogeneously distributed throughout the drug delivery device. As a result, the release characteristics of the pharmacologically active agent from the drug delivery device are enhanced.
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Citations
41 Claims
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1. A method of making a drug delivery device, comprising the steps of:
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(a) preparing a coatable composition comprising one or more biodegradable polymeric materials, one or more pharmacologically active agents, and one or more biocompatible solvents;
(b) coating the composition to form a film;
(c) drying the coated film until the coated film can be formed into a cohesive body;
(d) forming said cohesive body; and
(e) compressing the cohesive body to form a drug delivery device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A drug delivery device comprising a compressed matrix comprising at least one biodegradable polymeric material and a plurality of lipospheres comprising an encapsulated pharmacologically active agent, wherein said plurality of lipospheres is substantially homogeneously distributed within the matrix.
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32. A drug delivery device comprising a compressed matrix comprising at least one biodegradable polymeric material and a plurality of microspheres comprising an encapsulated pharmacologically active agent, wherein said plurality of microspheres is substantially homogeneously distributed within the matrix.
- 33. A drug delivery device comprising a compressed matrix comprising at least one biodegradable protein and a macromolecular pharmacologically active agent, wherein said macromolecular pharmacologically active agent is substantially homogeneously distributed within the matrix.
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34. A method of erecting a local therapeutic response in a patient in need of such treatment comprising the step of delivering a drug delivery device to the site at which a local therapeutic response is desired, wherein said drug delivery device comprises a compressed matrix comprising at least one biodegradable polymeric material, at least one pharmacologically active agent, and at least one biocompatible solvent, wherein said pharmacologically active agent is substantially homogeneously distributed within the matrix.
Specification