High definition electrical impedance tomography methods for the detection and diagnosis of early stages of breast cancer
First Claim
1. A method of imaging objects in a medium, the objects having specific impedances which are different from the specific impedance of the medium comprising, a) applying an electrical current to the medium at various locations, b) detecting voltages produced by the current which has passed through the medium from the surface of the medium at various locations, c) iteratively repeating steps a) and b), changing the value and locations for applying the electrical current and measuring the voltages, d) successively determining the region of the medium in which the objects are located with increasing accuracy by processing values of the detected voltages, using an algorithm to solve the field conditions in the medium, thereby determining a region in the medium in which the objects are located, e) successively determining the location, shape, and conductivity of the objects with increasing accuracy by i) determining a pattern of convergence, ii) selecting a function which approximates the determined pattern, iii) extrapolating the function for a predetermined number of iterations, iv) determining the boundary conditions of the region of objects v) repeating the iterations in the region defined by the boundaries, until convergence of the pattern and the values of voltage occurs, and f) displaying the results graphically.
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Abstract
The HDEIT method of the present invention permits one to use a variety of such indices to distinguish a tumour from normal surrounding tissue because it produces the value of the tissue characteristic at each zone in the tissues measured in accordance with the applied frequency. The tumour distinguishing analysis may be applied to the HDEIT image, or may be applied to the data that comprise the image without generating the image. Such methods are intended to permit the detection of tumors that are too small to be accurately seen in an image, but produce a large enough index for diagnostic purposes. One can apply this capability of the HDEIT method in a number of ways. For example, one can quickly scan the breast at low resolution, perform a distinguishing analysis for tumors, and then only perform a longer-duration high resolution scan if there was an indication of a diagnostically significant area to be examined.
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Citations
16 Claims
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1. A method of imaging objects in a medium, the objects having specific impedances which are different from the specific impedance of the medium comprising,
a) applying an electrical current to the medium at various locations, b) detecting voltages produced by the current which has passed through the medium from the surface of the medium at various locations, c) iteratively repeating steps a) and b), changing the value and locations for applying the electrical current and measuring the voltages, d) successively determining the region of the medium in which the objects are located with increasing accuracy by processing values of the detected voltages, using an algorithm to solve the field conditions in the medium, thereby determining a region in the medium in which the objects are located, e) successively determining the location, shape, and conductivity of the objects with increasing accuracy by i) determining a pattern of convergence, ii) selecting a function which approximates the determined pattern, iii) extrapolating the function for a predetermined number of iterations, iv) determining the boundary conditions of the region of objects v) repeating the iterations in the region defined by the boundaries, until convergence of the pattern and the values of voltage occurs, and f) displaying the results graphically.
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2. A method of imaging objects in a medium, the objects having a specific impedance which is different than the specific impedance of the medium comprising
a) initializing the conductivity distribution K, b) running a basic algorithm for n iterations, c) saving the conductivity distribution, d) locating peaks with a peak detection method at n +1 iterations, e) compensating for resolution with a new conductivity scheme at n+2 iterations, f) comparing calculated with known K for agreement, i) if agreement is obtained, output results, ii) if no agreement is obtained rerun step e).
- 5. A method of detecting malignant and benign tumors in a breast comprising positioning an electrode array consisting of pairs of electrodes on the surface of the breast, passing current between selected pairs of electrodes sequentially, measuring the voltages between electrode pairs not carrying said currents,and calculating the position, size and malignancy of tumors from the potential and conductivity information derived from said voltage measurements.
- 6. A method of detecting malignant and benign tumors in a breast comprising positioning an electrode array consisting of pairs of electrodes on the surface of a dielectric container containing a conductive fluid, immersing said breast in said fluid, passing current between selected pairs of electrodes sequentially, measuring the voltages between electrode pairs not carrying said currents, and calculating the position, size, and malignancy of tumors from the potential and conductivity information derived from said voltage measurements.
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7. A method of imaging an inhomogeneous or homogeneous medium and objects located therein, the objects having specific electrical properties which are different from the specific electrical properties of the adjacent medium comprising,
a) applying an electrical current to the medium at various locations, b) detecting voltages produced by the current which has passed through the medium from the surface of the medium at various locations, c) repeating steps a) and b), changing the value and locations for applying the electrical current and measuring the voltages, d) successively determining the region of the medium in which the objects are located with increasing accuracy by processing values of the detected voltages, using an algorithm to solve the field equations in the medium, thereby determining a region in the medium in which the objects are located, e) successively determining the location, shape, and conductivity of the objects with increasing accuracy by i) determining a pattern of convergence, ii) selecting a function which approximates the determined pattern, iii) extrapolating the function for a predetermined number of iterations, iv) determining the boundary conditions of the region of objects v) repeating the iterations in the region defined by the boundaries, until convergence of the pattern and the values of voltage occurs, and f) displaying the results graphically.
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8. A method of imaging an inhomogeneous or homogeneous medium and objects located therein, the objects having specific electrical properties which are different than the specific electrical properties of the adjacent medium comprising
a) initializing the electrical properties distribution, b) running the basic algorithm for n iterations, c) saving the conductivity distribution, d) locating peaks with a peak detection method at n +1 iterations, e) compensating for resolution by applying the basis algorithm withiin the restricted region with a new conductivity scheme at n+2 iterations, f) comparing calculated potential with measured potentials for agreement, i) if agreement is obtained, output results, ii) if no agreement is obtained rerun step e).
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11. A method of detecting malignant and benign tumors in a breast comprising positioning an electrode array on the surface of the breast, passing current between selected pairs of electrodes sequentially, measuring the voltages between electrode pairs not carrying said currents, and calculating the position, size and malignancy of tumors from the potential and conductivity information derived from said voltage measurements.
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12. A method of detecting malignant and benign tumors in a breast comprising positioning an electrode array on the inner surface of a dielectric container containing a conductive fluid, immersing said breast in said fluid, passing current between selected pairs of electrodes sequentially, measuring the voltages between electrode pairs not carrying said currents, and calculating the position, size, and malignancy of tumors from the potential and conductivity information derived from said voltage measurements.
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13. A method of detecting malignant and benign tumors in a body part comprising positioning an electrode array on the surface of the body part, passing current between selected pairs of electrodes sequentially, measuring the voltages between electrode pairs not carrying said currents, and calculating the position, size and malignancy of tumors from the potential and conductivity information derived from said voltage measurements.
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14. A method of detecting malignant and benign tumors in a body part comprising positioning an electrode array on the inner surface of a dielectric container containing a conductive fluid, immersing said body part in said fluid, passing current between selected pairs of electrodes sequentially, measuring the voltages between electrode pairs not carrying said currents, and calculating the position, size, and malignancy of tumors from the potential and conductivity information derived from said voltage measurements.
Specification