Production of gamma linolenic acid by a delta6-desaturase
First Claim
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1. An isolated nucleic acid encoding an evening primrose Δ
- 6-desaturase.
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Abstract
Linoleic acid is converted into γ-linolenic acid by the enzyme Δ6-desaturase. The present invention is directed to isolated nucleic acids comprising the Δ6-desaturase gene. More particularly, the isolated nucleic acid comprises the promoter, coding region and termination regions of the Δ6-desaturase gene. The present invention provides recombinant constructions comprising the Δ6-desaturase coding region in functional combination with heterologous regulatory sequences. The nucleic acids and recombinant constructions of the instant invention are useful in the production of GLA in transgenic organisms.
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Citations
46 Claims
- 1. An isolated nucleic acid encoding an evening primrose Δ
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3. An isolated nucleic acid that codes for the amino acid sequence of SEQ ID NO:
- 27.
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36. A method of inducing production of gamma linolenic acid (GLA) in an organism deficient or lacking in or producing low levels of GLA and linoleic acid (LA) which comprises transforming said organism with an isolated nucleic acid encoding bacterial Δ
- 6-desaturase and an isolated nucleic acid encoding Δ
12-desaturase.
- 6-desaturase and an isolated nucleic acid encoding Δ
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37. A method of inducing production of gamma linolenic acid (GLA) in an organism deficient or lacking in or producing low levels of GLA and linoleic acid (LA) which comprises transforming said organism with at least one expression vector comprising an isolated nucleic acid encoding evening primrose Δ
- 6-desaturase and an isolated nucleic acid encoding Δ
12desaturase.
- 6-desaturase and an isolated nucleic acid encoding Δ
Specification