Method for detecting body condition using nano and microdevices

• US 20020111551A1
• Filed: 11/30/2000
• Published: 08/15/2002
• Est. Priority Date: 11/30/2000
• Status: Abandoned Application

• Current Assignee: Xillus, Inc.
• Original Assignee: Xillus, Inc.
• Inventors: Smith, Jeffrey M., Scott, Mark D., Hirsch, Robert S., Peterson, James E., Olsen, Arlen L., Bender, Gerald E., Donnelly, Denis P., Smith, Laura B., Stinchcomb, Audra L., Erlach, Julian Van
• Application Number:
  US09/727,749
• Publication Number:
  US 20020111551A1
• Time in Patent Office: Days
• US Class Current: 600/423
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/02014 Determining aneurysm
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14539 for measuring pH

Abstract

A method for detecting body condition using nano and microdevices is disclosed. The microdevice or nanodevice is inserted into a fluid stream within a body, and used in detecting a bodily condition. The bodily condition may be myocardial infarction, stroke, sickle cell anemia, phlebitis, or a vascular aneurysm. The micro or nano device may be detected using electron paramagnetic resonance (EPR), electron spin resonance (ESR), and nuclear magnetic resonance (NMR).

Claims

1. A method for diagnosis comprising the steps of:

providing at least one of a microdevice and a nanodevice;

inserting at least one of said microdevice and a nanodevice into a fluid stream within a body, and

detecting a bodily condition.

2. The method of claim 1, wherein said bodily condition is at least one of myocardial infarction, stroke, sickle cell anemia, phlebitis, and vascular aneurysm.

3. The method of claim 1, wherein at least one of said nanodevice and said microdevice is a resonance type device.

4. The method of claim 1, further comprising the step of

detecting at least one of said nanodevice and said microdevice by one of electron paramagnetic resonance (EPR), electron spin resonance (ESR), and nuclear magnetic resonance (NMR).

5. The method of claim 1, wherein the step of detecting includes molecules selected from the group consisting of free radicals, odd electron molecules, transition metal complexes, lanthanade ions and triplet state molecules.

6. The method of claim 1, wherein at least one of said microdevice and said nanodevice includes a circuit feature selected from the group consisting of a diagnostic system, a transmitter, a receiver, a battery, a transistor, a capacitor, and a detector.

7. The method of claim 1, wherein the step of providing further comprises forming a circuit feature using one of optical lithography, electron beam lithography, ion beam lithography, X-ray lithography, and spatial phase-locked electron beam lithography.

8. The method of claim 1, wherein at least one of said nanodevice and said microdevice is a passive biological sensor.

9. The method of claim 1, wherein at least one of said nanodevice and said microdevice is a resonance type device.

10. The method of claim 1, further comprising the step of:

detecting at least one of said nanodevice and said microdevice by one of electron paramagnetic resonance (EPR), electron spin resonance (ESR), and nuclear magnetic resonance (NMR).

11. The method of claim 1, wherein at least one of said nanodevice and said microdevice includes a material selected from the group consisting of phosphorus, arsenic, sulfur, germanium and organic free-radicals.

12. The method of claim 11, wherein said organic free-radical is Di-phenyl-b-picryl-hydrazyl.

14. The method of claim 13, further comprising the step of chemically modifying at least one of said nanodevice and said microdevice such that it is adapted to prolong vascular retention, prevent immunologic detection, or prevent unwanted endocytosis by cells.

15. The method of claim 14, further comprising the step of chemically modifying at least one of said nanodevice and said microdevice with an organo hydroxyl.

16. The method of claim 15, wherein said organo hydroxyl group is selected from the group consisting of poly (ethylene glycol), methoxypoly (ethylene glycol).

17. The method of claim 13, further comprising attaching a lipid anchor to at least one of said nanodevice and said microdevice with an organo hydroxyl.

13. A method comprising:

providing at least one of a nanodevice and a microdevice,

inserting at least one of said nanodevice and said microdevice in a fluid stream within a body, wherein at least one of said nanodevice and said microdevice is extracellular; and

detecting a body condition.