Acoustic border detection using power modulation

• US 20020111553A1
• Filed: 04/08/2002
• Published: 08/15/2002
• Est. Priority Date: 02/11/2000
• Status: Active Grant

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Prater, David M., Brock-Fisher, George A.
• Granted Patent: US 6,997,875 B2
• Time in Patent Office: Days
• US Class Current: 600/443
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039

Abstract

The method of the invention controls an ultrasound system to identify a boundary between a tissue region and a blood-filled region that lies within an ROI. The method initially administers a contrast agent to the region of interest and then transmits first and second ultrasound beams at a different power levels into the ROI. Signal returns from the first and second beams are processed to derive first and second digital values, respectively. It has been determined that, under certain circumstances, a phase change of echo returns occurs at the boundary between tissue and blood-containing contrast agent. Detection of the phase change enables precise identification of the boundary, based upon the time segment in which the phase change is detected. Accordingly, time segment values of the first and second stored digital values are then phase-compared to enable determination of a boundary location between the tissue region and the blood-filled region by detection of the phase change.

Claims

1. A method for enabling an ultrasound system to identify a boundary between a tissue area and a blood-filled area, both lying within a region of interest ROI) to which a contrast agent has been administered, said method comprising the steps of:

a) transmitting a first ultrasound beam at a first power level into said ROI, processing first echo return signals and storing first digital values in accord therewith;

b) transmitting a second ultrasound beam at a second power level into said ROI, processing second echo return signals and storing second digital values in accord therewith; and

c) deriving phase information from coherent time segments of said first digital values and second digital values to determine a boundary location between said tissue area and said blood-filled area.

2. The method as recited in claim 1 wherein step c) applies a threshold test to said second digital values in order to determine if said difference value is of sufficient magnitude to enable said deriving step.

3. The method as recited in claim 1, wherein step c) derives differences between said first echo return signals and said second echo return signals and employs said differences to determine said boundary location between said tissue area and said blood-filled area.

4. The method as recited in claim 1 wherein said phase information evidences a boundary when a time segment of said first digital values and said second digital values evidence an out-of-phase relationship.

5. The method as recited claim 1 wherein said phase information evidences a boundary when a time segment of said first digital values and second digital values evidence an in-phase relationship.

6. The method as recited in claim 1 wherein one or more frequency components of the second ultrasound beam are modulated in phase with respect to said first ultrasound beam.

7. The method as recited in claim 1 wherein said first ultrasound beam and said second ultrasound beam are transmitted in phase coherence when considering a reference time.

8. The method as recited in claim 1 wherein said first ultrasound beam and said second ultrasound beam are transmitted in phase opposition when considering a reference time.

9. A memory media including instructions for controlling an ultrasound system to identify a boundary between a tissue area and a blood-filled area, both lying within a region of interest ROI) to which a contrast agent has been administered, said memory media comprising:

a) means for controlling said ultrasound system to transmit a first ultrasound beam at a first power level into said ROI, to process first echo return signals and store first digital values in accord therewith;

b) means for controlling said ultrasound system to transmit a second ultrasound beam at a second power level into said ROI, to process second echo return signals and store second digital values in accord therewith; and

c) means for controlling said ultrasound system to derive phase information from coherent time segments of said first digital values and second digital values to determine a boundary location between said tissue area and said blood-filled area.

10. The memory media as recited in claim 9 wherein means c) controls said ultrasound system to apply a threshold test to said second digital values in order to determine if said difference value is of sufficient magnitude to enable said deriving step.

11. The memory media as recited in claim 9, wherein said phase information evidences a boundary when a time segment of said first digital values and said second digital values evidence an out-of-phase relationship.

12. The memory media as recited in claim 9, wherein said phase information evidences a boundary when a time segment of said first digital values and second digital values evidence an in-phase relationship.

13. The memory media as recited in claim 9, wherein means a) and means b) control said ultrasound system to cause one or more frequency components of said first ultrasound beam to be modulated in phase with respect to said second ultrasound beam.

14. The memory media as recited in claim 9 wherein means a) and means b) control said ultrasound system to cause said first ultrasound beam and said second ultrasound beam to be transmitted in phase coherence when considering a reference time.

15. The memory media as recited in claim 9 wherein means a) and means b) control said ultrasound system to cause said first ultrasound beam and second ultrasound beam to be transmitted in phase opposition when considering a reference time.

17. The method as recited in claim 16, comprising the further step of:

determining a boundary between said fluid-filled cavity and said surrounding tissue by detecting a region where brighter areas of the fluid-filled cavity adjoin darker areas of said surrounding tissue.

18. The method as recited in claim 17, comprising the further step of:

performing real time calculations employing said determined boundary.

20. The memory media as recited in claim 19, further comprising:

d) means for controlling said ultrasound system to determine a boundary between said fluid-filled cavity and said surrounding tissue by detecting of a region where brighter areas of the fluid-filled cavity adjoin darker areas of said surrounding tissue.

21. The memory media as recited in claim 20, further comprising:

d) means for controlling said ultrasound system to perform real time calculations employing said determined boundary.

16. An ultrasound method for determining boundaries of a fluid-filled cavity, comprising the steps of:

introducing a contrast agent into a fluid-filled cavity within a body; and

imaging the fluid-filled cavity and surrounding tissue such that an image is created where the contrast agent in the fluid-filled cavity is represented in brighter intensities than is said surrounding tissue;

applying a threshold value to pixel data values comprising regions of the image;

classifying brighter areas of the image as representing the fluid-filled cavity and darker areas of the image as representing surrounding tissue.

19. A memory media including instructions for controlling an ultrasound system to determine boundaries of a fluid-filled cavity into which a contrast agent has been introduced, comprising

a) means for controlling said ultrasound system to image the fluid-filled cavity and surrounding tissue such that an image is created where the contrast agent in the fluid-filled cavity is represented in brighter intensities than is said surrounding tissue;

b) means for controlling said ultrasound system to apply a threshold value to pixel data values comprising regions of the image; and

c) means for controlling said ultrasound system to classify brighter areas of the image as representing the fluid-filled cavity and darker areas of the image as representing surrounding tissue.