Apparatus for determining concentrations of hemoglobins

• US 20020111748A1
• Filed: 02/15/2002
• Published: 08/15/2002
• Est. Priority Date: 11/30/1999
• Status: Active Grant

• Current Assignee: Nihon Kohden Corporation
• Original Assignee: Nihon Kohden Corporation
• Inventors: Kobayashi, Naoki, Takamura, Yoshiaki, Ukawa, Teiji, Usuda, Takashi, Kanemoto, Michio
• Granted Patent: US 6,622,095 B2
• Time in Patent Office: Days
• US Class Current: 702/31
• CPC Class Codes: A61B 5/14551 for measuring blood gases

Abstract

An apparatus for determining concentrations of hemoglobins includes a light source for emitting lights of at least three different wavelengths, a first wavelength in a near-infrared region, a second wavelength in a red region, and a third wavelength in a red orange region, light receiving device for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue, attenuation ratio processing device for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving device, the variations are caused by a pulsation of blood and concentration ratio processing device for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing device.

Claims

1. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting lights of at least three different wavelengths, a first wavelength in a near-infrared wavelength region, a second wavelength in a red wavelength region, and a third wavelength in a red orange wavelength region;

a light receiving means for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations are caused by a pulsation of blood; and

concentration ratio processing means for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing means.

2. An apparatus for determining concentrations of hemoglobins according to claim 1, wherein the concentration ratio processing means is configured so as to process a proportion between an ever-changing concentration of oxyhemoglobin, an ever-changing concentration of methemoglobin, and an ever-changing concentration of mathylene blue when medical treatment of methemoglobinemia is performed by administration of methylene blue into a living tissue, provided that at least a concentration of deoxyhemoglobin and that of carboxyhemoglobin remains unchanged.

15. An apparatus for determining concentrations of hemoglobins according to claim 1, wherein the light source for emitting lights of at least three different wavelengths, a first wavelength selected from a near-infrared wavelength region of 790 to 1000 nm, a second wavelength from a red wavelength region of 640 to 675 nm, and a third wavelength from a red orange wavelength region of 590 to 660 nm.

3. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting a plurality of lights of different wavelengths;

light receiving means for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations caused by a pulsation of blood;

concentration ratio processing means for processing concentration ratios of at least oxyhemoglobin, deoxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing means; and

oxygen saturation processing means for processing one of a functional oxygen saturation and a fractional oxygen saturation based on an output signals of the concentration ratio processing means.

11. An apparatus for determining concentrations of hemoglobins as claimed in claim 3, wherein the light source for emitting lights are at least three different wavelengths, a first wavelength in a near-infrared region, a second wavelength in a red region, and a third wavelength in a red orange region.

13. An apparatus for determining concentrations of hemoglobins as claimed in claim 12, wherein a predetermined threshold is set for an attenuation ratio to be processed by the attenuation ratio processing means, and

further comprising;

display means for displaying an alarm when an attenuation ratio processed for the hemoglobin to which the switch means has been switched has exceeded the threshold value.

16. An apparatus for determining concentrations of hemoglobins according to claim 15, wherein the third wavelength in a red orange wavelength region is 621 nm.

19. The apparatus for determining concentrations of hemoglobins according to claim 18, wherein the input means corresponds to calibration value input means, and the concentration variation processing means processes variation in the concentration since the reference time by inputting a tentative value by way of the calibration value input means as a concentration of light-absorbing material in blood.

4. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting a plurality of lights of different wavelengths;

light receiving means for receiving light emitted by the light source, transmitted through a living tissue or reflected by a living tissue;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations caused by a pulsation of blood;

concentration ratio processing means for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing means; and

alarm display means for displaying an alarm in accordance with a level of a concentration ratio of methemoglobin obtained by the concentration ratio processing means.

5. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting a plurality of lights of different wavelengths;

light receiving means for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations caused by a pulsation of blood;

concentration ratio processing means for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing means;

event input means for inputting information on the medical treatment or information on a patient as an event when the event occurs; and

storage means for storing times when information is input and event information or input by the event input means, and the processing results output from the concentration ratio processing means.

6. An apparatus for determining concentrations of hemoglobins according to claim 5, further comprising:

display means for displaying the processing results in the form of a trend display together with the event information stored in the storage means at a corresponding time of the trend display.

7. An apparatus for determining concentrations of hemoglobins according to claim 5, further comprising:

an interface used for transmitting the event information, the times and the processing results, which are stored in the storage means, to an external device.

8. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting a plurality of lights of different wavelengths;

light receiving means for receiving light emitted by the light source transmitted through the living tissue or reflected by the living tissue;

calibration value input means for inputting a concentration value of at least one kind of light absorbing material in blood for calibration;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations caused by a pulsation of blood; and

concentration ratio processing means for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing means and the concentration of light-absorbing material input by way of the calibration value input means.

9. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting a plurality of lights of different wavelengths;

light receiving means for receiving light emitted by the light source, transmitted through or reflected by a living tissue;

a attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, which variations are caused by a pulsation of blood;

concentration ratio processing means for processing concentration ratios of at least oxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing means; and

select means for giving an instruction to process a concentration ratio of methemoglobin;

wherein when the select means does not give an instruction to process a concentration ratio of methemoglobin, the concentration ratio processing means processes at least a concentration ratio of oxyhemoglobin on the basis of variations of signals output from the light receiving means upon reception of lights of at least two different wavelengths that are emitted from the light source and transmitted through and reflected by a living tissue, and

wherein when the select means gives an instruction to process a concentration ratio of methehemoglobin, the concentration ratio processing means processes at least concentration ratios of oxyhemoglobin and methemoglobin on the basis of variations of signals output from the light receiving means upon reception of lights of at least three different wavelengths that are emitted from the light source and transmitted through and reflected by a living tissue.

10. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting a plurality of lights of different wavelengths;

light receiving means for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations caused by a pulsation of blood;

concentration ratio processing means for processing concentration ratios of at least oxyhemoglobin deoxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing means; and

display means for displaying measured values of oxyhemoglobin, deoxyhemoglobin and methemoglobin on the X-Y coordinates.

12. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting lights of at least three different wavelengths, a first wavelength in a near infrared region, a second wavelength in a red region, and a third wavelength in a red orange region;

light receiving means for receiving light emitted by the light source, transmitted through a living tissue or reflected by the living tissue;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations are caused by a pulsation of blood; and

concentration ratio processing means for processing concentration ratios of at least oxyhemoglobin, carboxyhemoglobin and methemoglobin based on the output signals from the attenuation ratio processing means; and

switch means for causing the concentration ratio processing means to selectively process a concentration ratio of carboxyhemoglobin to that of methemoglobin.

14. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting lights of at least three different wavelengths, a first wavelength in a near-infrared region, a second wavelength in a red region, and a third wavelength in a red orange region;

light receiving means for receiving light emitted by the a light source, transmitted through a living tissue or reflected by the living tissue;

attenuation ratio processing means for processing attenuation ratios associated with concentrations of carboxyhemoglobin and methemoglobin in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations are caused by a pulsation of blood; and

display means for displaying an alarm when at least one of a processed attenuation ratio of carboxyhemoglobin and a processed attenuation ratio of methemoglobin has exceeded a range of a predetermined threshold value, the threshold value being set for an attenuation ratio of carboxyhemoglobin and an attenuation ratio of methemoglobin which are to be processed by the attenuation ratio processing means.

17. An apparatus for determining concentrations of hemoglobins comprising:

a light source for emitting a plurality of lights of different wavelengths;

light receiving means for receiving light emitted by the light source, transmitted through a living tissue or reflected by a living tissue;

calibration value input means for inputting a concentration value of at least one kind of light absorbing material in blood for calibration;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations caused by a pulsation of blood;

storage means for storing data concerning the attenuation ratios; and

concentration ratio processing means for retroactively re-process of at least a concentration ratio of oxyhemoglobin and a concentration ratio of methemoglobin, through use of the data stored in the storage means and the concentrations of light-absorbing materials in blood entered by way of the calibration value input means.

18. An apparatus for determining concentrations of hemoglobins, comprising

a light source for emitting a plurality of lights of different wavelengths;

light receiving means for receiving a plurality of light emitted by the light source, transmitted through a living tissue or reflected by a living tissue;

input means for entering a reference time;

attenuation ratio processing means for processing attenuation ratios between the wavelengths in accordance with variations of received-light output signals in each of the wavelengths output from the light receiving means, the variations caused by a pulsation of blood; and

concentration variation processing means for processing variation in the concentration of at least one of carboxyhemoglobin and methemoglobin having arisen since the reference time entered by way of the input means.