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Differentially expressed epitopes and uses thereof

  • US 20020115065A1
  • Filed: 08/27/2001
  • Published: 08/22/2002
  • Est. Priority Date: 08/28/2000
  • Status: Abandoned Application
First Claim
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1. A process for identifying a disease associated molecular marker which disease associated molecular marker is associated with a subset of cells, said process comprising the steps of:

  • a) incubating cells of a species with a library of binding molecules, combined with an incubation with diseased cells of the species;

    b) obtaining, from said incubation, a collection of diseased cells essentially free from non-diseased cells, by sorting said collection of diseased cells from non-diseased cells according to parameters that distinguish between said collection of diseased cells and said non-diseased cells;

    c) obtaining binding molecules from said collection of diseased cells;

    d) selecting, from said obtained binding molecules, an individual binding molecule that preferentially binds to said diseased cells in comparison to binding to said non-diseased cells;

    e) identifying a molecular marker which, in its disease associated form, binds to said individual binding molecule selected under step d), said disease associated molecular marker being associated with said collection of diseased cells obtainable according to step b); and

    f) establishing that said disease associated molecular marker has a counterpart associated with non-diseased cells wherein said counterpart is less capable of binding said individual binding molecule.

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