Pharmacophore recombination for the identification of small molecule drug lead compounds

• US 20020115107A1
• Filed: 12/28/2001
• Published: 08/22/2002
• Est. Priority Date: 03/27/1998
• Status: Abandoned Application

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Ellman, Jonathan A., Choong, Ingrid
• Application Number:
  US10/029,304
• Publication Number:
  US 20020115107A1
• Time in Patent Office: Days
• US Class Current: 435/7.1
• CPC Class Codes: C40B 30/04 by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• CPC Class Codes: G01N 2500/04 Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
• CPC Class Codes: G01N 33/531 Production of immunochemical test materials
• CPC Class Codes: G01N 33/6845 Methods of identifying protein-protein interactions in protein mixtures
• CPC Class Codes: Y10S 530/807 Hapten conjugated with peptide or protein

Abstract

A library of candidate target binding fragments (CTBF'"'"'s) each CTBF being a small organic molecule and having a linkable functional group (LFG) or blocked form thereof (BLFG), wherein the LFG or BLFG contains a linking group (LG), the LG being a disulfide group.

Claims