Receptor-mediated uptake of peptides that bind the human transferrin receptor
First Claim
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1. A composition of matter comprising a purified peptide containing at least one sequence chosen from HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2).
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Abstract
Peptides have been discovered which are capable of binding to and internalizing with the human transferrin receptor (hTfR). The sequences HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) are capable of binding to and internalizing with the human transferrin receptor. When these molecules were fused with other molecules, the fusion product was internalized in cells expressing hTfR. The sequences have use for targeting other peptides and proteins into cells expressing hTfR.
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Citations
7 Claims
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1. A composition of matter comprising a purified peptide containing at least one sequence chosen from HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2).
- 2. A composition comprising at least one peptide containing within its sequence at least one sequence chosen from HAIYPRH (Seq. ID No. 1) and THRPPMWSPVWP (Seq. ID No. 2) wherein said peptide is fused to a protein or another peptide.
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7. A composition of matter comprising a construct containing a DNA sequence which encodes at least one of the peptides HAIYPRH (Seq. ID No. 1) or THRPPMWSPVWP (Seq. ID No. 2) bound to a nucleotide sequence which encodes a peptide other than HAIYPRH (Seq. ID No. 1) or THRPPMWSPVWP (Seq. ID No. 2).
Specification