Localizing intravascular lesions on anatomic images

• US 20020115931A1
• Filed: 02/21/2001
• Published: 08/22/2002
• Est. Priority Date: 02/21/2001
• Status: Abandoned Application

• Current Assignee: Imetrx, Inc.
• Original Assignee: Imetrx, Inc.
• Inventors: Strauss, H. William, Kaufman, Leon, Ghazarossian, Vartan
• Application Number:
  US09/791,499
• Publication Number:
  US 20020115931A1
• Time in Patent Office: Days
• US Class Current: 600/420
• CPC Class Codes: A61B 2034/2051 Electromagnetic tracking systems
• CPC Class Codes: A61B 2034/2072 Reference field transducer attached to an instrument or patient
• CPC Class Codes: A61B 2090/365 augmented reality, i.e. correlating a live optical image with another image
• CPC Class Codes: A61B 2090/376 using X-rays, e.g. fluoroscopy
• CPC Class Codes: A61B 2090/3954 magnetic, e.g. NMR or MRI
• CPC Class Codes: A61B 2090/3983 Reference marker arrangements for use with image guided surgery
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/06 Devices, other than using radiation, for detecting or locating foreign bodies for removing same A61B17/50 ; determining position of probes within or on the body of the patient
• CPC Class Codes: A61B 6/00 Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment instruments measuring radiation intensity for application in the field of nuclear medicine, e.g. in vivo counting, G01T1/161; apparatus for taking X-ray photographs G03B42/02
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/5247 combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
• CPC Class Codes: A61M 25/0108 using radio-opaque or ultrasound markers
• CPC Class Codes: A61M 25/0127 Magnetic means; Magnetic markers
• CPC Class Codes: A61M 31/005 for contrast media

Abstract

Methods and systems for localizing intravascular lesion in a body lumen. In exemplary embodiments, the methods comprise providing or acquiring an image of the body lumen and displaying information about the lesion with or on the image. In some configurations the information is obtained with an intravascular catheter.

Claims

1. A method of localizing a lesion in a body lumen, the method comprising:

providing an image of the body lumen;

acquiring information about the lesion with a detecting device; and

displaying the information in a spatially correct distribution relative to the image of the body lumen.

2. The method of claim 1 wherein displaying comprises placing the information about the lesion in a substantially anatomically correct position on the image of the body lumen.

3. The method of claim 2 wherein the information is not anatomical.

4. The method of claim 1 wherein acquiring comprises measuring temperature, measuring content of the lesion, or measuring radiation.

5. The method of claim 1 wherein the detecting device comprises an intravascular catheter comprising at least one detector.

6. The method of claim 5 wherein acquiring comprises moving the catheter through the body lumen at a constant speed.

7. The method of claim 5 further comprising determining an absolute azimuthal orientation of the catheter.

8. The method of claim 7 wherein determining comprises rotating the catheter about a longitudinal axis until markers are viewable under radiographic imaging.

9. The method of claim 5 further comprising creating a coordinate system along the body lumen to facilitate placing the information in a spatially correct distribution relative to the lumen.

10. The method of claim 9 wherein creating comprises using a fitting program or a tracing program.

11. The method of claim 5 further comprising localizing the position of the catheter with respect to the body lumen.

12. The method of claim 5 comprising positioning the catheter in a stationary position at a targeted region of the body lumen.

13. The method of claim 1 further comprising delivering a contrast medium into the body lumen, wherein obtaining the image of the body lumen comprises using an MRI system.

14. The method of claim 1 wherein providing comprises obtaining the image of the body lumen with an external imaging system.

15. The method of claim 14 wherein obtaining the image comprises:

releasing a contrast medium into the body lumen during transit of the detecting device to the target site to create an opacified body lumen; and

imaging the opacified body lumen.

16. The method of claim 14 wherein obtaining the image of the body lumen comprises using one of a fluoroscopic imaging system or a CT system.

17. The method of claim 14 wherein obtaining the image of the body lumen comprises using an MRI system.

18. The method of claim 1 or 14 further comprising storing images of the body lumen in a computer memory.

19. The method of claim 18 further comprising combining a plurality of stored images of the body lumen to create the image.

20. The method of claim 1 further comprising marking the lesion in the body lumen with a marker that can be sensed by the detecting device.

21. The method of claim 20 wherein marking comprises binding a radiopharmaceutical to the lesion in the body lumen.

22. The method of claim 21 wherein the lesion is vulnerable plaque.

23. The method of claim 21 wherein acquiring information comprises measuring a count activity of the marked lesion.

24. The method of claim 1 or 23 further comprising adding standard deviation marks on the anatomic image to highlight a certainty level of the information.

25. The method of claim 23 wherein displaying comprises expressing the count activity.

26. The method of claim 1 wherein displaying comprises adding histogram bars onto the image.

27. The method of claim 1 wherein displaying comprises varying a brightness intensity along the lumen to indicate a severity of the lesion.

28. The method of claim 1 wherein displaying comprises providing azimuthal distribution information about the lesion.

29. The method of claim 1 wherein displaying comprises indicating distribution of the marker in the lesion.

30. The method of claim 1 wherein acquiring comprises taking readings only at a specific point in a patient'"'"'s electrocardiogram cycle.

31. The method of claim 1 further comprising compensating for a patient'"'"'s heartbeat and breathing during displaying.

32. The method of claim 1 wherein acquiring comprises taking a plurality of readings with the detecting device through a patient'"'"'s electrocardiogram cycle and selecting data from only a portion of the cardiac cycle for display purposes.

33. The method of claim 1 further comprising tracking a patient'"'"'s rigid movements.

34. The method of claim 33 wherein tracking comprises placing markers on at least one of a patient'"'"'s body and a platform beneath the patient'"'"'s body.

36. The method of claim 35 further comprising generating a coordinate system of the body lumen to orient the count activity information onto the anatomic image of the body lumen.

37. The method of claim 36 wherein generating is carried out with a tracing algorithm.

38. The method of claim 36 wherein generating is carried out with a fitting program.

39. The method of claim 35 wherein placing comprises moving a catheter having the detector(s) through the body lumen.

40. The method of claim 35 further comprising tracking the longitudinal positioning and azimuthal orientation of the detector(s).

41. The method of claim 35 wherein displaying comprises showing at least azimuthal distribution of the vulnerable plaque and a longitudinal position of the vulnerable plaque.

42. The method of claim 35 wherein displaying comprises providing bar histograms representing the amount of plaque by the length of the bars.

43. The method of claim 35 wherein displaying comprises providing a line having a color to indicate the amount of plaque.

44. The method of claim 35 wherein displaying comprises providing standard deviation marks.

46. The method of claim 45 wherein providing comprises externally imaging the body lumen to obtain the anatomic image.

47. The method of claim 46 wherein the detecting device comprises a catheter having detectors.

48. The method of claim 47 wherein the detectors detect one of radiolabel marker counts, temperature levels, MRI parameters, x-ray density, paramagnetic, ferromagnetic or iodinated contrast agents, ultrasound signal, infrared, or optical signature.

49. The method of claim 45 wherein displaying comprises superimposing the azimuthal distribution information over the anatomic image of the body lumen.

35. A method of characterizing a vulnerable plaque lesion in a body lumen, the method comprising:

externally imaging the body lumen to obtain an anatomic image of the body lumen;

placing detector(s) in the body lumen to distinguish vulnerable plaque from stable lesions; and

displaying the vulnerable plaque information on the anatomic image.

45. A method of displaying information about a lesion in a body lumen, the method comprising:

providing an anatomic image of the body lumen with an image capture apparatus;

acquiring azimuthal distribution information about the lesion with a detecting device; and

displaying the azimuthal distribution information with the anatomic image of the body lumen.

50. A system for localizing lesions in a body lumen, the system comprising:

a catheter body comprising a proximal and distal portion;

at least one detector that can obtain information about the lesion;

a plurality of markers positioned on the distal portion of the catheter that allow a user to track the azimuthal orientation of the distal portion of the catheter body; and

a computer that superimposes the information obtained by the detector on an anatomic image of the body lumen.

51. The system of claim 50 further comprising imaging means for obtaining the anatomic image of the body lumen, said imaging means being coupled to the computer.

52. The system of claim 50 wherein the markers comprise a magnetic marker.

53. The system of claim 50 wherein the markers comprises tantalum, gold, or platinum.

54. The system of claim 50 wherein the markers have a shape such that their azimuthal orientation can be obtained in a radiographic image.

55. The system of claim 50 wherein the information comprises at least one of a count activity, azimuthal position of the marked lesion in the body lumen, and longitudinal position of the marked lesion in the body lumen.

56. The system of claim 50 wherein the computer is programmed to position the information in an anatomically correct position on the anatomic image of the body lumen.

57. The system of claim 50 further comprising a display for displaying the information and anatomic image of the body lumen.

59. The system of claim 58 wherein the detecting device comprises an intravascular catheter comprising at least one radiation detector.

60. The system of claim 59 wherein the catheter comprises a plurality of markers disposed in a spaced relationship on the catheter.

61. The system of claim 58 wherein the anatomic image is an angiographic image.

58. A system for displaying an anatomic image of a body lumen, the system comprising:

an imaging device that can acquire an anatomic image of the body lumen;

a detecting device to obtain information of a marked lesion in the body lumen; and

a computer configured to store the anatomic image(s) of the body lumen, wherein the computer receives the information from the detecting device and displays the information on the stored anatomic image.

62. A system for localizing lesions in a body lumen, the system comprising:

imaging means for obtaining an image of the body lumen;

detecting means for characterizing the lesion in the body lumen; and

means for storing the image of the body lumen and superimposing information about the lesion onto the image of the body lumen.