Compositions useful for regulating hair growth containing metal complexes of oxidized carbohydrates

• US 20020119174A1
• Filed: 07/19/2001
• Published: 08/29/2002
• Est. Priority Date: 07/26/2000
• Status: Abandoned Application

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Gardlik, John Michael, Comstock, Bryan Gabriel, Severynse-Stevens, Diana
• Application Number:
  US09/909,440
• Publication Number:
  US 20020119174A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/58 Metal complex; Coordination compounds
• CPC Class Codes: A61K 31/7032 attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/49 containing heterocyclic compounds
• CPC Class Codes: A61K 8/4953 containing pyrimidine ring derivatives, e.g. minoxidil
• CPC Class Codes: A61K 8/60 Sugars; Derivatives thereof
• CPC Class Codes: A61K 8/73 Polysaccharides
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/733 Alginic acid; Salts thereof
• CPC Class Codes: A61K 8/736 Chitin; Chitosan; Derivatives thereof
• CPC Class Codes: A61K 8/737 Galactomannans, e.g. guar; Derivatives thereof
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: A61Q 3/00 : Manicure or pedicure preparations
• CPC Class Codes: A61Q 5/006 : Antidandruff preparations
• CPC Class Codes: A61Q 5/02 : Preparations for cleaning the hair
• CPC Class Codes: A61Q 5/06 : Preparations for styling the hair, e.g. by temporary shaping or colouring
• CPC Class Codes: A61Q 7/00 : Preparations for affecting hair growth

Abstract

A stable cosmetic, dermatological, or pharmaceutical composition comprising: (a) from about 0.001% to about 99.9%, by weight, of at least one metal complex of an oxidized carbohydrate; wherein the metal complex of an oxidized carbohydrate is neither zinc gluconate nor manganese gluconate nor lithium gluconate; and (b) from about 0.1% to about 99.999%, by weight, of a vehicle, wherein the vehicle comprises at least about 5%, by weight of the composition, of propylene glycol.

Claims

1. A stable cosmetic, dermatological, or pharmaceutical composition comprising:

(a) from about 0.001% to about 99.9%, by weight, of at least one metal complex of an oxidized carbohydrate;

wherein said metal complex of an oxidized carbohydrate is neither zinc gluconate nor manganese gluconate nor lithium gluconate; and

(b) from about 0.1% to about 99.999%, by weight, of a vehicle, wherein said vehicle comprises at least about 5%, by weight of the composition, of propylene glycol.

2. The composition of claim 1, wherein said composition comprises:

(a) from about 0.001% to about 15%, by weight, of said at least one metal complex of an oxidized carbohydrate; and

(b) from about 85% to about 99.999%, by weight, of said vehicle.

3. The composition of claim 1, wherein the metal comprising said at least one metal complex is selected from the group consisting of lithium, sodium, silver, gold, zinc, copper, nickel, iron, chromium, calcium, magnesium, molybdenum, cobalt, palladium, platinum, tin, and mixtures thereof.

4. The composition of claim 3, wherein said metal comprising said at least one metal complex is selected from the group consisting of lithium, sodium, zinc, copper, and mixtures thereof.

5. The composition of claim 4, wherein said metal comprising said at least one metal complex is zinc.

6. The composition of claim 1, wherein said oxidized carbohydrate is selected from the group consisting of oxidized aldoses, oxidized ketoses, oxidized trioses, oxidized tetroses, oxidized pentoses, oxidized hexoses, and mixtures thereof.

7. The composition of claim 1, wherein said oxidized carbohydrate is selected from the group consisting of ribonic acid;

ribulonic acid;

arabinonic acid;

xylonic acid;

xylulonic acid;

lyxonic acid;

allonic acid;

altronic acid;

gluconic acid;

mannonic acid;

gulonic acid;

idonic acid;

galactonic acid;

talonic acid;

glucoheptonic acid;

psiconic acid;

fructonic acid;

sorbonic acid;

tagatonic acid;

lactobionic acid;

maltobionic acid;

isomaltobionic acid;

cellobionic acid;

oxidized malto-oligosaccharide;

oxidized cello-oligosaccharide;

oxidized cellulose;

chitin;

gum arabic;

gum karaya;

gum xanthan;

oxidized gum guar;

oxidized locust bean gum;

oxidized agars;

oxidized algins;

oxidized gellan gum; and

mixtures thereof.

8. The composition of claim 7, wherein said oxidized carbohydrate is selected from the group consisting of lactobionic acid;

maltobionic acid;

isomaltobionic acid;

cellobionic acid; and

mixtures thereof.

9. The composition of claim 8, wherein said oxidized carbohydrate is lactobionic acid.

10. The composition of claim 1, wherein said oxidized carbohydrate is not gluconate.

11. The composition of claim 1, wherein said composition further comprises a metal complex of an oxidized carbohydrate selected from the group consisting of zinc gluconate, manganese gluconate, lithium gluconate, and mixtures thereof.

12. The composition of claim 1, wherein the carbohydrate comprising said oxidized carbohydrate is selected from the group consisting of monosaccharides, disaccharides, polysaccharides, and mixtures thereof.

13. The composition of claim 1, wherein said vehicle comprises at least one ingredient selected from the group consisting of solvents;

thickeners;

propellants;

powders;

fillers;

plasticizers;

lubricants; and

emollients and humectants; and

mixtures thereof.

14. The composition of claim 13, wherein said vehicle comprises a solvent selected from the group consisting of water, C₂ to C₃ monohydric alcohols, propylene glycol, and mixtures thereof.

15. The composition of claim 14, wherein said vehicle comprises a solvent comprising:

(a) from about 50% to about 70%, by weight, of water;

(b) from about 20% to about 40%, by weight, of ethanol; and

(c) from about 5% to about 20%, by weight, of propylene glycol.

16. The composition of claim 14, wherein said solvent comprises from about 10% to about 15%, by weight, of propylene glycol.

17. The composition of claim 1, wherein said composition further comprises at least one ingredient selected from the group consisting of surfactants, conditioning agents, cationic polymers, anti-dandruff actives, activity enhancers, penetration enhancers, dyes, suspending agents, non-steroidal anti-inflammatory drugs, topical anesthetics, sunscreen actives, flavoring agents, preservatives, sweeteners, and mixtures thereof.

18. The composition of claim 17, wherein:

(a) said conditioning agents are selected from the group consisting of polydimethylsiloxane, polydiethylsiloxane, polymethylphenylsiloxane, amodimethicone, trimethylsilylamodimethicone, paraffin oil, mineral oil, polydecene, 1-decene homopolymer, C₈-C₁₀ triester of trimethylolpropane, polyethylene glycol, and mixtures thereof; and

(b) said cationic polymers selected from the group consisting of Polyquaternium 10, Polyquaternium 24, guar hydroxypropyltrimethylammonium chloride, Polyquaternium 16, and mixtures thereof; and

(c) said anti-dandruff actives selected from the group consisting of zinc pyrithione, sulfur, ketoconazole, climbazole, and mixtures thereof; and

(d) said activity enhancers selected from the group consisting of minoxidil, finasteride, cyclosporin, ketoconazole, triclocarbon, triclosan, zinc pyrithione, itraconazole, hinokitiol, mipirocin, hydrocortisone, tenidap, triiodothyrionine, latanoprost, isotretinoin, acitretin, tazarotene, nicotinic acid, niacinamide, glycosaminoglycanase inhibitors, ethylenediaminetetraacetic acid, oleanolic acid, ursolic acid, interleukin-1 inhibitors, interleukin-6 inhibitors, interleukin-10 promotors, saponins, triterpenes, betulinic acid, betulonic acid, crataegolic acid, celastrol, asiatic acid, inhibitors of 5-α

-reductase, progesterone, 1,4-methyl4-azasteroids, 17-β

-N,N-diethylcarbamoyl-4-methyl-4-aza-5-α

-androstan-3-one, androgen receptor antagonists, cyproterone acetate, azelaic acid, diazoxide, potassium channel openers, cromakalin, phenytoin, dutasteride, coal tar, zinc gluconate, manganese gluconate, glucocortisoids, macrolides, aminexil, ginkgo biloba, ivy, methyl salicylate, clinacycin hydrochloride, benzoyl peroxide, benzyl peroxide, minocyclin, and mixtures thereof;

(e) said penetration enhancers selected from the group consisting of propan-2-ol;

1-propan-1,2-diol;

propan-1-ol;

di-isopropyl adipate;

dimethylsulfonyl oxide;

octonol;

niacinamide; and

mixtures thereof; and

(f) said suspending agents selected from the group consisting of ethylene glycol monostearate, ethylene glycol distearate, stearyl stearate, cetyl palmitate, xanthan gum, copolymers of acrylic acid crosslinked with polyallylsucrose, methylcellulose, hydroxybutyl methylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose, hydroxyethylcellulose, guar gum, polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl guar gum, starch, trihydroxystearin, and mixtures thereof.

19. The composition of claim 18, wherein said activity enhancers are selected from the group consisting of minoxidil, finasteride, cyclosporin, ketoconazole, triclocarbon, triclosan, zinc pyrithione, itraconazole, tenidap, niacinamide, triterpenes, betulinic acid, betulonic acid, zinc gluconate, manganese gluconate, lithium gluconate, glucocortisoids, and mixtures thereof.

20. The composition of claim 1, wherein said oxidized carbohydrate is amido-, amino-, or phospho-substituted.

28. The composition of claim 1, wherein said at least one metal complex of an oxidized carbohydrate is zinc lactobionate.

29. The composition of claim 1, wherein said composition is packaged as a component part of a kit, said kit containing at least one additional component for use in pretreatment or post-treatment steps, said steps being part of a regimen for regulating hair growth performance.

30. A method for treating hyperandrogenic conditions selected from the group consisting of benign prostatic hyperplasia, androgenetic alopecia, acne vulgaris, female hirsuitism, seborrhea, and prostatic carcinoma, in a human in need of such treatment by disrupting the activity of a hormone selected from the group consisting of testosterone, testosterone derivatives, dihydrotestosterone, dihydrotestosterone derivatives, and combinations thereof, comprising administering to the human an effective amount of a composition according to claim 1.

31. The method of claim 30, wherein said composition is administered orally, parenterally, or topically.

32. The method claim 31, wherein said composition is administered in a form selected from the group consisting of tablets, capsules, caplets, creams, gels, hydrogels, lotions, shampoos, rinses, tonics, sprays, ointments, mousses and pomades.

33. The method of claim 31, wherein said composition is administered topically.

34. A method for treating dandruff comprising administering to a mammal, an effective amount of a composition according to claim 1.

35. A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to claim 1.

36. A method for regulating the growth of finger nails or toe nails comprising administering to a mammal, an effective amount of a composition according to claim 1.

37. A method for styling the hair, comprising administering to the hair of a mammal, an effective amount of a composition according to claim 1.

39. The composition of claim 38, wherein the composition is the product of a process comprising the steps (a) to (c) in any order:

(a) adding from about 3% to about 10%, by weight, of a metal salt, and mixing;

(b) adding from about 5% to about 25%, by weight, of a carboxylic acid of a carbohydrate, and mixing; and

(c) adding from about 0.1% to about 99.999%, by weight, of a vehicle, and mixing;

wherein said product comprises from about 0.001% to about 15%, by weight, of said metal complex of an oxidized carbohydrate.

40. The composition of claim 38, wherein the metal comprising said metal salt is selected from the group consisting of lithium, sodium, silver, gold, zinc, copper, nickel, iron, chromium, calcium, magnesium, molybdenum, cobalt, palladium, platinum, tin, and mixtures thereof.

41. The composition of claim 40, wherein said metal comprising at least one said metal complex is selected from the group consisting of lithium, sodium, zinc, copper, and mixtures thereof.

42. The composition of claim 41, wherein said metal comprising said at least one metal complex is zinc.

43. The composition of claim 38, wherein said carboxylic acid of a carbohydrate is selected from the group consisting of lactobionic acid;

maltobionic acid;

isomaltobionic acid;

cellobionic acid; and

mixtures thereof.

44. The composition of claim 43, wherein said carboxylic acid of a carbohydrate is lactobionic acid.

45. The composition of claim 38, wherein the salt portion of said metal salt is selected from the group consisting of chlorides, sulfates, acetates, oxides, and mixtures thereof.

46. The composition of claim 38, wherein said metal salt is selected from the group consisting of zinc sulfate, zinc acetate, zinc oxide, cupric chloride, cupric sulfate, cupric acetate, and copper oxide.

47. The composition of claim 46, wherein said metal salt is zinc sulfate.

48. The composition of claim 43, wherein said metal salt is zinc sulfate.

49. A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to claim 38.

50. A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to claim 48.

21. A stable cosmetic, dermatological, or pharmaceutical composition comprising:

(a) zinc lactobionate;

(b) zinc gluconate, zinc pyrithione, or both; and

(c) a vehicle.

22. A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to claim 21.

24. A method for regulating the growth of hair comprising administering to a mammal, an effective amount of a composition according to claim 23.

25. The composition of claim 23, wherein said at least one metal complex of an oxidized carbohydrate has a solubility in water of at least 40%.

26. The composition of claim 25, wherein said at least one metal complex of an oxidized carbohydrate has a solubility in water of at least 50%.

27. The composition of claim 26, wherein said at least one metal complex of an oxidized carbohydrate has a solubility in water of at least 60%.

23. A stable cosmetic, dermatological, or pharmaceutical composition comprising:

(a) from about 0.001% to about 99.9%, by weight, of at least one metal complex of an oxidized carbohydrate having a solubility in water of at least 10%; and

(b) from about 0.1% to about 99.999%, by weight, of a vehicle, wherein said vehicle comprises at least about 5%, by weight of the composition, of propylene glycol.

38. A stable cosmetic, dermatological, or pharmaceutical composition that is the product of a process comprising the steps (a) to (c) in any order:

(a) adding from about 1% to about 25%, by weight, of a metal salt, and mixing;

(b) adding from about 1% to about 30%, by weight, of a carboxylic acid of a carbohydrate, and mixing; and

(c) adding from about 0.1% to about 99.999%, by weight, of a vehicle, and mixing;

wherein said product comprises from about 0.001% to about 99.9%, by weight, of at least one metal complex of an oxidized carbohydrate, wherein said metal complex of an oxidized carbohydrate is neither zinc gluconate nor manganese gluconate nor lithium gluconate.