Sensitive and selective chemical sensor with nanostructured surfaces

• US 20020122179A1
• Filed: 08/09/2001
• Published: 09/05/2002
• Est. Priority Date: 01/10/2001
• Status: Active Grant

• Current Assignee: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
• Original Assignee: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE
• Inventors: Pipino, Andrew C.R.
• Granted Patent: US 6,515,749 B2
• Time in Patent Office: Days
• US Class Current: 356/440
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: G01N 21/554 detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance

Abstract

A chemical sensor is provided which includes an optical resonator including a nanostructured surface comprising a plurality of nanoparticles bound to one or more surfaces of the resonator. The nanoparticles provide optical absorption and the sensor further comprises a detector for detecting the optical absorption of the nanoparticles or their environment. In particular, a selective chemical interaction is provided which modifies the optical absorption of the nanoparticles or their environment, and an analyte is detected based on the modified optical absorption. A light pulse is generated which enters the resonator to interrogate the modified optical absorption and the exiting light pulse is detected by the detector.

Claims

1. A chemical sensor comprising an optical resonator including a nanostructured surface comprising a plurality of nanoparticles bound to at least one surface of the resonator.

2. A sensor as claimed in claim 1 wherein said nanoparticles provide optical absorption and said sensor further comprises means for detecting the optical absorption of at least one of said nanoparticles.

3. A sensor as claimed in claim 1 wherein a selective chemical interaction is provided which modifies the optical absorption of one of (i) at least one nanoparticle and (ii) the environment of the at least one nanoparticle, and an analyte is detected based on the modified optical absorption.

4. A sensor as claimed in claim 3 wherein said sensor further comprises means for generating a light pulse which enters the resonator to interrogate the modified optical absorption, said detecting means comprising a detector for detecting the light pulse when the light pulse exits the resonator.

5. A sensor as claimed in claim 3 wherein said selective chemical interaction is provided by a direct chemical interaction between the at least one nanoparticle and the analyte which alters the absorption of the at least one nanoparticle.

6. A sensor as claimed in claim 3 wherein said at least one nanoparticle comprises a coated nanoparticle having a coating that selectively binds to the analyte to produce an effective coating refractive index change and said selective chemical reaction comprises the selective binding of the coating to the analyte.

7. A sensor as claimed in claim 3 wherein at least one nanoparticle comprises a plurality of nanoparticles which support a surface plasmon polariton resonance.

8. A sensor as claimed in claim 3 wherein said at least one nanoparticle comprises a nanoparticle selected from the group consisting of gold, silver, cadmium sulfide and zinc selenide nanoparticles.

9. A sensor as claimed in claim 3 wherein said at least one nanoparticle comprises a nanoparticle selected from the group consisting of spherical, spheroidal, and tetrahedral nanoparticles.

10. A sensor as claimed in claim 3 wherein said at least one nanoparticle comprises a gold nanosphere.

11. A sensor as claimed in claim 3 wherein said at least one surface comprises an ultra-smooth polished surface and said optical resonator comprises a resonator employing intracavity total internal reflection so as to permit the use of evanescent wave cavity ring-down spectroscopy in probing the modified optical absorption.

12. A sensor as claimed in claim 1 wherein said sensor is used to detect NO₂ and nitrocompounds and said nanoparticles comprise gold nanoparticles.

13. A sensor as claimed in claim 1 wherein said sensor is used to detect volatile organic compounds and said nanoparticles have a coating of cyclodextrin molecules.

15. A sensor as claimed in claim 14 wherein said nanoparticles comprise gold nanospheres.

16. A sensor as claimed in claim 14 wherein said light pulse comprises a laser pulse.

18. A sensor as claimed in claim 17 wherein said selective chemical interaction is provided by a direct chemical interaction between the at least one nanoparticle and the analyte which alters the absorption of the at least one nanoparticle.

19. A sensor as claimed in claim 17 wherein said at least one nanoparticle comprises a coated nanoparticle having a coating that selectively binds to the analyte to produce an effective coating refractive index change and said selective chemical reaction comprises the selective binding of the coating to the analyte.

20. A sensor as claimed in claim 17 wherein said at least one nanoparticle comprises a nanoparticle selected from the group consisting of gold, silver, cadmium sulfide and zinc selenide nanoparticles.

14. A chemical sensor comprising a resonator providing intracavity total internal reflection and comprising first and second opposed planar coated facets and a further convex facet acting as a total internal reflection surface;

a light source for producing a light pulse which enters through said first coated surface and exits through said second coated surface;

a plurality of nanoparticles covalently attached to said convex surface so as to absorb an evanescent field produced by said convex surface.

17. A chemical sensor comprising a resonator defining a cavity, a light source for generating light which enters said cavity, said resonator providing intracavity total internal reflection of said light, and including at least one surface having a plurality of nanoparticles bound thereto such that the optical absorption of one of (i) at least one of the nanoparticles and (ii) the environment of the nanoparticles is modified in response to a selective chemical interaction, said sensor further comprising means for detecting an analyte based on the modified optical absorption.