Dendrimeric support or carrier macromolecule
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Abstract
The present invention provides a family of dendrimers that are useful as supports, vectors, carriers or delivery vehicles for a variety of compounds in biomedical and technological applications. In particular, the macromolecules may be used for the delivery of drugs, genetic material, imaging components or other functional molecule to which they can be conjugated. An additional feature of the macromolecules is their ability to be targeted for certain organs, tumors, or types of tissues.
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Citations
48 Claims
- 1. An anhydride having the structure:
- 6. An anhydride having the structure:
- 8. A dendrimer which is substantially free of urea side products, said dendrimer comprising a subunit having the structure:
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24. A dendrimer comprising a subunit having the structure:
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25. A dendrimer comprising a subunit having the structure:
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26. A dendrimer having the structure:
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28. A dendrimer comprising the structure:
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30. A dendrimer comprising the structure:
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32. A biological compartment comprising a membrane defining an interior space, said interior space comprising a dendrimer comprising a subunit having the structure:
- 33. A biological compartment comprising a membrane defining an interior space, said interior space comprising a dendrimer comprising a subunit having the structure:
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39. A method of producing a protected first generation dendrimer substantially free of urea side products, said dendrimer comprising a subunit having the structure:
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48. A method of enhancing water solubility of an agent, said method comprising forming a conjugate between said agent and a dendrimer comprising a subunit having the structure:
Specification