Spectrophotometric blood glucose determination apparatus and determination method thereof

• US 20020123677A1
• Filed: 09/28/2001
• Published: 09/05/2002
• Est. Priority Date: 12/28/2000
• Status: Abandoned Application

• Current Assignee: BIOX Corporation (Clearwater Fine Foods, Inc.)
• Original Assignee: BOIS Labs Incorporated
• Inventors: Amano, Toshio, Miki, Keizaburo, Hoshina, Sadayori
• Application Number:
  US09/966,531
• Publication Number:
  US 20020123677A1
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips

Abstract

To provide a portable blood glucose determination apparatus and a determination method for either invasive or non-invasive measurement of glucose concentration in blood by optical observation excelling in measuring accuracy and reproducibility.

A spectrophotometric blood glucose determination apparatus is an infra-red quantitative analysis instrument for measuring concentration of glucose in blood, provided with the following units numbered (1) through (3):

(1) a near-infrared irradiating unit for continuously dividing wavelengths of near-infrared light in a wavelength range of 0.8 to 2.5 μm into fine portions with acousto-optic tunable filter and irradiating the subject of measurement therewith;

(2) a photoelectric conversion unit for receiving and photoelectrically converting lights transmitted by the subject of measurement irradiated therewith by the near-infrared irradiating unit; and

(3) a glucose concentration computing unit for determining the glucose concentration in the blood within the subject of measurement by analyzing an absorbance spectrum obtained on the basis of detection signals resulting from photoelectric conversion by the photoelectric conversion unit,

and a spectrophotometric blood glucose determination method including each step using the above described each unit.

Claims

1. A spectrophotometric blood glucose determination apparatus capable of measuring the concentration of glucose in blood, comprising:

(1) near-infrared irradiating means for continuously dividing the wavelengths of near-infrared light in a wavelength range of 0.8 to 2.5 μ

m into fine portions and irradiating a subject of measurement therewith;

(2) photoelectric conversion means for receiving and photoelectrically converting the lights transmitted or reflected by said subject of measurement irradiated therewith by said near-infrared irradiating means; and

(3) glucose concentration computing means for determining the glucose concentration in the blood within said subject of measurement by analyzing the absorbance spectrum obtained on the basis of detection signals resulting from photoelectric conversion by said photoelectric conversion means.

2. The spectrophotometric blood glucose determination apparatus as set forth in claim 1, in which said near-infrared irradiating means is a near-infrared spectrophotometric unit, comprising:

(i) a light source;

(ii) an acousto-optic variable oscillation tunable filter, on which light comes incident from said light source, for emitting near-infrared light in the wavelength range of 0.8 to 2.5 μ

m;

(iii) a high frequency vibrator for applying acoustic vibration to said acousto-optic tunable filter; and

(iv) a high frequency generating unit for applying a high frequency to said high frequency vibrator.

3. The spectrophotometric blood glucose determination apparatus as set forth in claim 2, wherein the medium of said acousto-optic tunable filter is a birefringent crystalline material.

4. The spectrophotometric blood glucose determination apparatus, as set forth in claim 1, wherein said photoelectric conversion means is a photoelectric conversion unit consisting of a light receiving element for receiving the light transmitted by the subject of measurement and supplying detection signals giving an absorbance spectrum.

5. The spectrophotometric blood glucose determination apparatus as set forth in claim 1, wherein said glucose concentration computing means comprises an absorbance spectrum waveform analyzing unit to which detection signals from said light receiving element are supplied and a glucose concentration computing unit for converting the absorbance spectrum into glucose concentrations.

6. The spectrophotometric blood glucose determination apparatus as set forth in claim 5, wherein said absorbance spectrum is a blood spectrum resulting from the subtraction of a normal state spectrum from a hemostatic state spectrum figured out by an arithmetic circuit in an image processing manner.

7. The spectrophotometric blood glucose determination apparatus as set forth in claim 5, wherein wavelengths selected in said absorbance spectrum are converted values based on five or more wavelengths at 1.44 μ

m, 1.94 μ

m and in a 0.8 to 2.5 μ

m band.

8. The spectrophotometric blood glucose determination apparatus as set forth in claim 1, wherein said subject of measurement is part of a human body whose glucose concentration in blood is measurable.

9. The spectrophotometric blood glucose determination apparatus as set forth in claim 1, wherein fixing means for said subject of measurement is capable of giving rise to blood congestion by holding with pressure the position to be measured of a human body.

10. A spectrophotometric blood glucose determination method permitting determination of a concentration of glucose in blood, comprising:

(1) a near-infrared irradiating step of continuously dividing wavelengths of near-infrared light in a wavelength range of 0.8 to 2.5 μ

m into fine portions and irradiating a subject of measurement therewith;

(2) a photoelectric conversion step of receiving and photoelectrically converting the lights transmitted or reflected by said subject of measurement irradiated therewith at said near-infrared irradiating step; and

(3) a glucose concentration computing step of assessing the glucose concentration in the blood within said subject of measurement by analyzing and computing an absorbance spectrum obtained on the basis of detection signals resulting from photoelectric conversion at said photoelectric conversion step.

11. The spectrophotometric blood glucose determination method as set forth in claim 10, wherein said near-infrared irradiating step is a combination of:

(i) a sub-step of applying a high frequency onto a high frequency vibrator;

(ii) a sub-step at which the high frequency vibrator to which the high frequency was applied at said sub-step (i) applies acoustic vibration to an acousto-optic tunable filter; and

(iii) a sub-step of bringing light incident on an acousto-optic tunable filter, to which acoustic vibration is applied at said sub-step (ii), from a light source, and causing near-infrared light in the wavelength range of 0.8 to 2.5 μ

m to be emitted.

12. The spectrophotometric blood glucose determination method as set forth in claim 10, wherein the medium of said acousto-optic tunable filter is a birefringent crystalline material.

13. The spectrophotometric blood glucose determination method as set forth in claim 10, wherein said photoelectric conversion step is a combination of a sub-step of supplying light transmitted or reflected by the subject of measurement to a light receiving element and a sub-step at which the light receiving element supplies detection signals giving an absorbance spectrum.

14. The spectrophotometric blood glucose determination method as set forth in claim 10, wherein said glucose concentration computing step is a combination of an absorbance spectrum waveform analyzing step to which detection signals from said light receiving element are supplied and a glucose concentration computing step of converting the absorbance spectrum into glucose concentrations.

15. The spectrophotometric blood glucose determination method as set forth in claim 10, wherein said absorbance spectrum is a blood spectrum resulting from the subtraction of a normal state spectrum from a hemostatic state spectrum figured out by an arithmetic circuit in an image processing manner.

16. The spectrophotometric blood glucose determination method as set forth in claim 10, wherein wavelengths selected in said absorbance spectrum are converted values based on five or more wavelengths at 1.44 μ

m, 1.94 μ

m and in a 0.8 to 2.5 μ

m band.

17. The spectrophotometric blood glucose determination method as set forth in claim 10, wherein said subject of measurement is part of a human body whose glucose concentration in blood is measurable.

18. The spectrophotometric blood glucose determination method as set forth in claim 10, wherein said subject of measurement is a blood-congested part resulting from the holding of the measured region of a human body with pressure.