DEVICE FOR ENHANCED DELIVERY OF BIOLOGICALLY ACTIVE SUBSTANCES AND COMPOUNDS IN AN ORGANISM
First Claim
1. A device to enhance the delivery of a drug or other substance or compound of interest into a selected target organ or tissue of an organism, comprising a special apparatus, special electrodes, one of the special electrodes carrying a special container with the selected drug or other substance or compound of interest, said electrodes being capable of being positioned at preselected locations of said organ or tissue, wherein the electrodes are all connected with a selected energy source which generates and maintains an energy field before and during the enhanced delivery of said substance or compound, under the influence of which delivery is accomplished in a direction from the active to the passive electrode and into said organ or tissue.
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Accused Products
Abstract
A device to enhance the delivery of a drug or other substance of interest into a selected organ or tissue, comprising special electrodes, one of the electrodes carrying a container with the selected drug or other substance of interest, said electrodes being capable of being positioned at preselected locations of said organ or tissue, wherein the electrodes are all connected with a selected energy source which generates and maintains an energy field before and during the enhanced delivery of said substance, under the influence of which delivery is accomplished in a direction from the active to the passive electrode and into said organ or tissue. The energy source may be selected from suitable sources providing an electric field, a magnetic field, ultrasonic waves, high energy waves like laser beams, or a combination thereof. Further a method for the enhanced delivery of said drug or other substance of interest to an internal organ or target tissue of an organism, for example the brain, bypassing the blood-brain barrier, is disclosed.
52 Citations
41 Claims
- 1. A device to enhance the delivery of a drug or other substance or compound of interest into a selected target organ or tissue of an organism, comprising a special apparatus, special electrodes, one of the special electrodes carrying a special container with the selected drug or other substance or compound of interest, said electrodes being capable of being positioned at preselected locations of said organ or tissue, wherein the electrodes are all connected with a selected energy source which generates and maintains an energy field before and during the enhanced delivery of said substance or compound, under the influence of which delivery is accomplished in a direction from the active to the passive electrode and into said organ or tissue.
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14. Use of an electrode, provided with a drug or other substance or compound of interest, in the manufacture of an iontophoretic device, for the enhanced delivery of said substance or compound to a target organ or tissue of said organism without obtaining significant plasma levels of said drug, substance or compound by generating and maintaining an electric field over said target organ or tissue before and during the delivery of said drug or other substance or compound of interest.
- 16. An enhanced delivery of an effective amount of a drug or other biologically active substance or compound into an internal target organ or tissue of an organism, such as a mammal, particularly a human being, being in need of such a delivery with such a drug, or other substance or compound of interest, wherein said compound is enhanced as such to said organ or tissue from a carrying location in the body of said organism by means of energy-stimulated penetration generated and maintained by a field set between at least two electrodes being split or not, upon connection with a selected energy source, of which electrodes one electrode can function as an active electrode and one as passive electrode, of which at least one electrode is placed on the skin layer of said organism, and one electrode, having the opposite polarity, is placed near the place where said drug or other substance or compound of interest is to be delivered.
Specification