Waveforms for selective stimulation of central nervous system neurons

• US 20020123780A1
• Filed: 03/05/2001
• Published: 09/05/2002
• Est. Priority Date: 09/26/2000
• Status: Active Grant

• Current Assignee: Case Western Reserve University
• Original Assignee: Case Western Reserve University
• Inventors: McIntyre, Cameron C., Grill, Warren M.
• Granted Patent: US 6,560,490 B2
• Time in Patent Office: Days
• US Class Current: 607/72
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/3615 Intensity
• CPC Class Codes: A61N 1/36167 Timing, e.g. stimulation onset

Abstract

Asymmetric charge-balanced stimulation waveforms are defined and used for CNS stimulation with selective stimulation of either neuronal cell bodies or axon fibers of passage in favor of the other. A pre-pulse is followed by an opposite polarity stimulation pulse, with the pre-pulse being relatively low-amplitude and long-duration as compared to the stimulation pulse. The pre-pulse and stimulation pulse are charge-balanced to prevent tissue damage and electrode corrosion. The polarity of the pre-pulse and stimulation pulse control the selectivity of stimulation with respect to neuronal cell bodies versus axon fibers of passage. The waveform used in the stimulation method optionally includes a zero-amplitude phase having a duration of 0 to 500 microseconds.

Claims

1. An electrical waveform for stimulation of central nervous system tissue, said electrical waveform comprising:

a pre-pulse phase having a first polarity, a first amplitude and a first duration, said first amplitude and first duration together defining a pre-pulse charge having a first magnitude and said first polarity; and

,

a stimulation-pulse phase following said pre-pulse phase, said stimulation-pulse phase having a second polarity opposite said first polarity, a second amplitude and second duration less than said first duration, said second amplitude and second duration together defining a stimulation charge having said second polarity and a second magnitude that equals said first magnitude.

2. The electrical waveform as set forth in claim 1, wherein said first duration is at least eight times longer than said second duration.

3. The electrical waveform as set forth in claim 2, wherein said first duration is at least eight times longer than said second duration and less than or equal to twelve times longer than said second duration.

4. The electrical waveform as set forth in claim 1, further comprising:

a zero-amplitude phase located after said pre-pulse phase and before said stimulation-pulse phase, said zero-amplitude phase having a duration in the range of 0 to 500 microseconds.

5. The electrical waveform as set forth in claim 4, wherein said zero-amplitude phase is located immediately after said pre-pulse phase and immediately before said stimulation-pulse phase.

6. A method for selective electrical stimulation of central nervous system tissue, said method comprising:

transmitting a pre-pulse phase of a stimulation waveform into central nervous system tissue through an electrode contacting said central nervous system tissue, said pre-pulse phase of said stimulation waveform having a first polarity, a first amplitude and a first duration, said first amplitude and first duration together defining a pre-pulse charge having a first magnitude and said first polarity; and

,

after said step of transmitting a pre-pulse phase of a stimulation waveform, transmitting a stimulation-pulse phase of said stimulation waveform into said central nervous system tissue through said electrode, said stimulation-pulse phase of said stimulation waveform having a second polarity opposite said first polarity, a second amplitude and second duration less than said first duration, said second amplitude and second duration together defining a stimulation charge having said second polarity and a second magnitude that equals said first magnitude.

7. The method as set forth in claim 6, wherein said first duration of said pre-pulse phase is at least eight times longer than said second duration of said stimulation-pulse phase.

8. The method as set forth in claim 7, wherein said first duration of said pre-pulse phase is at least eight times and no more than twelve times longer than said second duration of said stimulation-pulse phase.

9. The method as set forth in claim 6, further comprising:

delaying for a select duration between said step of transmitting said pre-pulse phase and said step of transmitting said stimulation-pulse phase.

10. The method as set forth in claim 9, wherein said select duration is inclusively between 0 and 500 microseconds.

11. A method for selectively stimulating one of axons of passage and neuronal cells in favor of the other of axons of passage and neuronal cells in central nervous system tissue using electrical stimulation, said method comprising:

transmitting a pre-pulse phase of an electrical waveform into central nervous system tissue through an electrode contacting said central nervous system tissue, said pre-pulse phase of said waveform having a first polarity, a first amplitude and a first duration, said first amplitude and first duration together defining a pre-pulse charge having a first magnitude and said first polarity; and

,

after said step of transmitting a pre-pulse phase, transmitting a stimulation-pulse phase of said waveform into said central nervous system tissue through said electrode, said stimulation-pulse phase of said waveform having a second polarity opposite said first polarity, a second amplitude and second duration less than said first duration, said second amplitude and second duration together defining a stimulation charge having said first magnitude and said second polarity.

12. The method as set forth in claim 11, wherein said pre-pulse phase is cathodic and said stimulation-pulse phase is anodic to effect stimulation of neuronal cells in favor of axons of passage.

13. The method as set forth in claim 11, wherein said pre-pulse phase is anodic and said stimulation-pulse phase is cathodic to effect stimulation of axons of passage in favor of neuronal cells.

14. The method as set forth in claim 11, wherein said first duration of said pre-pulse phase is at least eight times longer than said second duration of said stimulation-pulse phase.

15. The method as set forth in claim 14, wherein said first duration of said pre-pulse phase is at least eight times and no more than twelve times longer than said second duration of said stimulation-pulse phase.

16. The method as set forth in claim 11, further comprising:

delaying for a select duration between said step of transmitting said pre-pulse phase and said step of transmitting said stimulation-pulse phase.

17. The method as set forth in claim 16, wherein said select duration is inclusively between 0 and 500 microseconds.

19. The apparatus as set forth in claim 18, wherein said first duration is at least eight times longer than said second duration.

20. The apparatus as set forth in claim 19, wherein said first duration is at least eight times longer than said second duration and less than or equal to twelve times longer than said second duration.

21. The apparatus as set forth in claim 18, wherein said stimulation waveform further comprises:

a zero-amplitude phase located after said pre-pulse phase and before said stimulation-pulse phase, said zero-amplitude phase having a duration in the range of 0 to 500 microseconds.

18. An apparatus for stimulating central nervous system tissue, said apparatus comprising:

an electrode adapted for contact with central nervous system tissue; and

,

an electrical stimulation waveform generator electrically connected to said electrode, said waveform generator adapted to generate and output to said electrode a stimulation waveform comprising;

a pre-pulse phase having a first polarity, a first amplitude and a first duration, said first amplitude and first duration together defining a pre-pulse charge having a first magnitude and said first polarity; and

,

a stimulation-pulse phase following said pre-pulse phase, said stimulation-pulse phase having a second polarity opposite said first polarity, a second amplitude and second duration less than said first duration, said second amplitude and second duration together defining a stimulation charge having said first magnitude and said second polarity.