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Compositions and methods for enhancing drug delivery across and into epithelial tissues

  • US 20020127198A1
  • Filed: 02/23/2001
  • Published: 09/12/2002
  • Est. Priority Date: 08/24/1999
  • Status: Active Grant
First Claim
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1. A method of targeting a compound to a gastrointestinal epithelium of an animal, the method comprising administering to the gastrointestinal epithelium a conjugate comprising the compound and a delivery-enhancing transporter, wherein:

  • i. the compound is attached to the delivery-enhancing transporter through a linker; and

    ii. the delivery-enhancing transporter comprises fewer than 50 subunits and comprises at least 5 guanidino or amidino moieties, thereby increasing delivery of the conjugate into the gastrointestinal epithelium compared to delivery of the compound in the absence of the delivery-enhancing transporter.

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