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Noninvasive vascular therapy

  • US 20020127230A1
  • Filed: 07/13/2001
  • Published: 09/12/2002
  • Est. Priority Date: 01/15/1999
  • Status: Active Grant
First Claim
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1. A method for destroying or impairing target cells that comprise a lesion in the vascular system in a mammalian subject comprising:

  • administering to the subject a therapeutically effective amount of a photosensitizing agent, wherein said photosensitizing agent selectively binds to target cells of the lesion;

    irradiating at least a portion of the subject with light at a wavelength absorbed by said photosensitizing agent, wherein said light is provided by a light source that is external to the intact body of the subject; and

    wherein said irradiation is at a relatively low fluence rate that results in the activation of said photosensitizing agent or said prodrug product wherein said PDT drug is cleared from the skin and subcutaneous tissues of the subject prior to said irradiation.

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