Pharmaceutical composition containing IL-10

• US 20020128447A1
• Filed: 02/26/2002
• Published: 09/12/2002
• Est. Priority Date: 08/09/1995
• Status: Active Grant

• Current Assignee: Armo BioSciences Inc.
• Original Assignee: Renovo Ltd. (Bentley Park Ltd.)
• Inventors: Ferguson, Mark W.J.
• Granted Patent: US 7,052,684 B2
• Time in Patent Office: Days
• US Class Current: 530/351
• CPC Class Codes: A61K 38/2066 IL-10
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention provides IL-10 or a fragment or a partially modified form thereof for use in promoting the healing of wounds and fibrotic disorders with reduced scarring and methods for same.

Claims

1. The use of IL-10 or a fragment or a partially modified form thereof in promoting the healing of wounds or fibrotic disorders with reduced scarring.

2. The use of IL-10 or a fragment or a partially modified form thereof according to claim 1 in conjunction with a pharmaceutically acceptable carrier, diluent or excipient.

3. The use of IL-10 or a fragment or a partially modified form thereof according to any one of the preceding claims in conjunction with a composition for promoting the healing of wounds with reduced scarring.

4. The use of IL-10 or a fragment or a partially modified form thereof according to any one of the preceding claims in conjunction with a composition for promoting the healing of chronic wounds.

5. A method for promoting the healing of wounds or fibrotic disorders with reduced scarring comprising the use of IL-10 or a fragment or a partially modified form thereof according to any one of the preceding claims.

6. A method according to claim 5, IL-10 being administered to a wound site or site of a fibrotic disorder.

7. A method according to claim 6, wherein IL-10 or a fragment or a partially modified form thereof being administered at a concentration of between about 1 μ

M and about 10 μ

M.

8. A method according to claim 7, IL-10 or a fragment or a partially modified form thereof being administered at a concentration of between about 2.5 μ

M and about 5 μ

M.

9. A method according to any one of claims 5-8 for use in conjunction with a method for promoting the healing of wounds or fibrotic disorder with reduced scarring.

10. A method according to any one of claims 5-9 for use in conjunction with a method for promoting the healing of chronic wounds.