Cardiac rhythm management system using time-domain heart rate variablility indicia
First Claim
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1. A method including:
- detecting heart contractions over a time period;
obtaining a time-domain first signal representing time intervals between the detected heart contractions;
filtering the first signal to obtain a time-domain second signal including frequency components substantially in a first frequency band, wherein the second signal is influenced by both sympathetic and parasympathetic components of an autonomic nervous system;
filtering the first signal to obtain a time-domain third signal including frequency components substantially in a second frequency band, wherein the third signal is influenced by the parasympathetic component of the autonomic nervous system and not substantially influenced by the sympathetic component of the autonomic nervous system; and
providing an indication associated with a balance between the sympathetic and parasympathetic components of the autonomic nervous system based on the time-domain second and third signals.
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Abstract
A cardiac rhythm management system that provides an indication of patient well-being based on the autonomic balance between the sympathetic and parasympathetic/vagal components of the autonomic nervous system, using time-domain processing of frequency components of a heart rate interval signal.
112 Citations
32 Claims
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1. A method including:
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detecting heart contractions over a time period;
obtaining a time-domain first signal representing time intervals between the detected heart contractions;
filtering the first signal to obtain a time-domain second signal including frequency components substantially in a first frequency band, wherein the second signal is influenced by both sympathetic and parasympathetic components of an autonomic nervous system;
filtering the first signal to obtain a time-domain third signal including frequency components substantially in a second frequency band, wherein the third signal is influenced by the parasympathetic component of the autonomic nervous system and not substantially influenced by the sympathetic component of the autonomic nervous system; and
providing an indication associated with a balance between the sympathetic and parasympathetic components of the autonomic nervous system based on the time-domain second and third signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method including:
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detecting heart contractions over a time period;
obtaining a time-domain first signal representing time intervals between the detected heart contractions;
bandpass filtering the first signal, using a lowpass cutoff frequency that is approximately equal to 0.15 Hz and a highpass cutoff frequency that is approximately equal to 0.04 Hz, to obtain a time-domain low frequency (LF) signal;
bandpass filtering the first signal, using a lowpass cutoff frequency that is approximately equal to 0.40 Hz and a highpass cutoff frequency that is approximately equal to 0.15 Hz, to obtain a time-domain high frequency (HF) signal; and
obtaining variances of the LF and HF signals; and
ratioing the variances of the LF and HF signals to obtain an LF/HF ratio signal. - View Dependent Claims (21, 22, 24, 25, 26, 27, 28, 29, 30, 31)
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23. A system including:
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a heart contraction detection module, providing a heart rate interval signal carrying information regarding intervals between heart contractions;
a low frequency (LF) bandpass filter, coupled to the detection module for receiving the heart rate interval signal, the LF bandpass filter providing a time-domain LF signal output that is influenced by both sympathetic and parasympathetic components of an autonomic nervous system;
a high frequency (HF) bandpass filter, coupled to the detection module for receiving the heart rate interval signal, the HF bandpass filter providing a time-domain HF signal output having higher frequency components than the LF signal output, the HF signal output being influenced by the parasympathetic component of the autonomic nervous system and not substantially influenced by the sympathetic component of the autonomic nervous system;
an LF variance module coupled to the LF bandpass filter for receiving the LF signal, the LF variance module providing a resulting LF variance signal;
a HF variance module, coupled to the HF bandpass filter for receiving the HF signal, the HF variance module providing a resulting HF variance signal; and
an autonomic balance indicator module, coupled to the LF and HF variance modules, and providing an indication of a balance between sympathetic and parasympathetic components of the autonomic nervous system based on the LF and HF variance signals.
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32. A system including:
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a heart contraction detection module, providing a heart rate interval signal carrying information regarding intervals between heart contractions;
a bandpass filter, coupled to the detection module for receiving the heart rate interval signal, the bandpass filter providing a time-domain bandpass filtered signal output;
an variance module coupled to the bandpass filter for receiving the bandpass filtered signal, the variance module providing a resulting variance signal;
an autonomic balance indicator module, coupled to the variance module, and providing an indication of a balance between sympathetic and parasympathetic components of an autonomic nervous system, based on the variance signal; and
an antitachyarrhythmia therapy module, adapted to be coupled to a heart, the therapy module providing antitachyarrhythmia therapy to the heart based at least in part on the indication of the balance between the sympathetic and parasympathetic components of the autonomic nervous system.
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Specification