AHF associated dispersion system and method for preparation
First Claim
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1. A method for complexing AHF in a dispersed medium, comprising:
- a) providing an AHF protein, b) altering the conformational state of said AHF protein to expose hydrophobic domains therein, c) binding a stabilizer to said exposed hydrophobic domains, and d) at least partially reversing said alteration to associate at least a portion of said protein with said stabilizer.
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Abstract
A method for complexing AHF in a dispersed medium, includes: a) providing an AHF protein, b) altering the conformational state of the AHF protein to expose hydrophobic domains therein, c) binding a stabilizer to the exposed hydrophobic domains, and d) at least partially reversing the alteration to associate at least a portion of the protein with the stabilizer. A pharmaceutically effective stabilized AHF dosage wherein above about 0.5%, preferably above about 3%, and more preferably above about 25%, of the AHF molecule is associated with a stabilizer is also disclosed.
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26 Claims
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1. A method for complexing AHF in a dispersed medium, comprising:
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a) providing an AHF protein, b) altering the conformational state of said AHF protein to expose hydrophobic domains therein, c) binding a stabilizer to said exposed hydrophobic domains, and d) at least partially reversing said alteration to associate at least a portion of said protein with said stabilizer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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- 21. A pharmaceutically effective stabilized AHF dosage wherein greater than about 0.5% of the AHF molecule is encapsulated by a stabilizer.
Specification