Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor
First Claim
1. A method of calibrating a non-invasive blood glucose measurement instrument to an individual, said method comprising the steps of:
- providing one or more targeted glycemic profiles;
manipulating said individual'"'"'s blood glucose level such that patterns of said profiles are reproduced by subject'"'"'s own glycemic profile;
performing reference blood glucose measurements at predetermined intervals;
gathering non-invasive spectral measurements with said non-invasive glucose measurement instrument at said predetermined intervals; and
generating a calibration that correlates said reference measurements and said spectral samples, such that an algorithm predicts a blood glucose level from a new spectral sample.
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Abstract
A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvasive spectral measurements are made using the noninvasive glucose monitor. Through controlled oral ingestion by the subject of calculated amounts of carbohydrate, the subject'"'"'s blood glucose level is manipulated to mimic the patterns of the targeted profiles. During a first visit, a first profile of a pair is induced; during a second visit the inverse of the first profile is induced. The targeted profiles produce reference blood glucose values in which correlation to sampling factors is reduced or eliminated, thus the resulting calibration is correlated to glucose, and not to other analytes, sampling factors or environmental factors. A formula is provided for calculating the required amount of carbohydrate to ingest to induce a targeted glycemic profile in a test subject.
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Citations
31 Claims
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1. A method of calibrating a non-invasive blood glucose measurement instrument to an individual, said method comprising the steps of:
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providing one or more targeted glycemic profiles;
manipulating said individual'"'"'s blood glucose level such that patterns of said profiles are reproduced by subject'"'"'s own glycemic profile;
performing reference blood glucose measurements at predetermined intervals;
gathering non-invasive spectral measurements with said non-invasive glucose measurement instrument at said predetermined intervals; and
generating a calibration that correlates said reference measurements and said spectral samples, such that an algorithm predicts a blood glucose level from a new spectral sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification