Drug eluting encapsulated stent
First Claim
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1. A device for intravascular placement, the device comprising:
- a substantially cylindrical hollow body;
a membrane positioned about a periphery of the body, the membrane containing at least one pharmacotherapeutic agent for the treatment or prevention of restenosis; and
a plurality of micropores throughout the membrane.
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Abstract
A stent substantially completely encapsulated with a microporous polymeric membrane is provided. Encapsulation of the stent may be accomplished by an electrostatic deposition process. The microporous polymeric membrane may contain variable concentrations of one or more pharmacotherapeutic agents. After deployment to a site of interest, the stent and more specifically, the membrane, provides local delivery of sustained or controlled therapeutic dose of one or more of suitable pharmacotherapeutic agent.
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Citations
17 Claims
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1. A device for intravascular placement, the device comprising:
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a substantially cylindrical hollow body;
a membrane positioned about a periphery of the body, the membrane containing at least one pharmacotherapeutic agent for the treatment or prevention of restenosis; and
a plurality of micropores throughout the membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 17)
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11. A method of manufacturing an intravascular device for local delivery of a pharmacotherapeutic agent, the method comprising:
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forming a polymeric solution;
adding at least one pharmacotherapeutic agent into the polymeric solution, so as to generate a polymer-agent mixture;
applying the mixture on to a periphery of an intravascular device, so as to encapsulate the device; and
permitting a porous membrane to form from the mixture applied to the device. - View Dependent Claims (12, 13, 14, 15, 16)
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Specification