Ligament and tendon replacement constructs and methods for production and use thereof

• US 20020133229A1
• Filed: 06/11/2001
• Published: 09/19/2002
• Est. Priority Date: 03/24/2000
• Status: Abandoned Application

• Current Assignee: Drexel University
• Original Assignee: Drexel University
• Inventors: Lu, Helen H., Cooper, James A., Attawia, Mohammed A., Laurencin, Cato T., Ko, Frank K.
• Application Number:
  US09/878,641
• Publication Number:
  US 20020133229A1
• Time in Patent Office: Days
• US Class Current: 623/13.17
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2230/0006 circular
• CPC Class Codes: A61F 2230/0019 rectangular
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body

Abstract

Degradable, polymeric fiber-based, three-dimensional braided scaffolds for use as graft materials in ligament and tendon repair, reconstruction and replacement are provided. Also provided are methods for preparing these scaffolds.

Claims

1. A replacement construct comprising a degradable, polymeric fiber-based, three-dimensional braided scaffold.

6. A method for repairing, replacing or reconstructing a damaged tendon or ligament in a patient comprising implanting at a damaged tendon or ligament the replacement construct of claim 1.

8. A method for producing a graft material composed of living cells in a degradable matrix comprising:

(a) harvesting, growing and passaging cells in tissue culture; and

(b) seeding the cultured cells onto the degradable, polymeric fiber-based, three-dimensional braided scaffold of claim 1.

9. The method of claim 8 wherein the cells are mesenchymal in origin.

10. The method of claim 8 wherein the cells generate mesenchymal cells.

11. The method of claim 10 wherein the cells are pluripotent stem cells.

2. A replacement construct comprising a degradable polymeric fiber-based, three-dimensional braided scaffold seeded with cells, ingrowth of which is support by the scaffold.

3. The replacement construct of claim 2 where the cells are mesenchymal in origin.

4. The replacement construct of claim 2 wherein the cells generate mesenchymal cells.

5. The replacement construct of claim 4 wherein the cells are pluripotent stem cells.

7. A method for repairing, replacing or reconstructing a damaged tendon or ligament in a patient comprising implanting at a damaged tendon or ligament the replacement construct of claim 2.