Microstructured dual sided membrane for tissue growth and regeneration

• US 20020133232A1
• Filed: 02/25/2002
• Published: 09/19/2002
• Est. Priority Date: 11/02/1993
• Status: Abandoned Application

• Current Assignee: Biolok International Incorporated (Biohorizons Incorporated)
• Original Assignee: Biolok International Incorporated (Biohorizons Incorporated)
• Inventors: Alexander, Harold, Ricci, John L.
• Application Number:
  US10/081,478
• Publication Number:
  US 20020133232A1
• Time in Patent Office: Days
• US Class Current: 623/23.5
• CPC Class Codes: A61B 17/68 Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin bone staples A61B17/0642
• CPC Class Codes: A61C 2008/0046 Textured surface, e.g. roughness, microstructure A61C8/0013 takes precedence
• CPC Class Codes: A61C 8/0012 characterised by the material or composition, e.g. ceramics, surface layer, metal alloy use of specific materials A61K6/00
• CPC Class Codes: A61C 8/0013 with a surface layer, coating
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61F 2/30767 Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
• CPC Class Codes: A61F 2/30771 applied in original prostheses, e.g. holes or grooves
• CPC Class Codes: A61F 2/3094 Designing or manufacturing processes
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/367 Proximal or metaphyseal parts of shafts trochanteric devices connected to said proximal parts A61F2/30739
• CPC Class Codes: A61F 2/3672 Intermediate parts of shafts
• CPC Class Codes: A61F 2/3676 Distal or diaphyseal parts of shafts
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/3804 for elbows
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2/4202 for ankles
• CPC Class Codes: A61F 2/4241 for hands, e.g. fingers
• CPC Class Codes: A61F 2/468 Testing instruments for artificial joints for testing non-implantable prostheses A61F2/76
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues of bone tissue onto implantable joints A61F2002/3093
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue of bone tissue onto implantable joints A61F2002/30932
• CPC Class Codes: A61F 2002/30028 : differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2002/30112 : Rounded shapes, e.g. with rounded corners
• CPC Class Codes: A61F 2002/30136 : undulated or wavy, e.g. serpentine-shaped or zigzag-shaped
• CPC Class Codes: A61F 2002/30153 : rectangular
• CPC Class Codes: A61F 2002/30158 : trapezoidal
• CPC Class Codes: A61F 2002/30322 : differing in surface structures
• CPC Class Codes: A61F 2002/30808 : parallel
• CPC Class Codes: A61F 2002/30818 : castellated or crenellated
• CPC Class Codes: A61F 2002/3082 : Grooves
• CPC Class Codes: A61F 2002/30823 : having the shape of a reverse dovetail
• CPC Class Codes: A61F 2002/30828 : parallel
• CPC Class Codes: A61F 2002/30836 : knurled
• CPC Class Codes: A61F 2002/30838 : Microstructures
• CPC Class Codes: A61F 2002/30879 : Ribs
• CPC Class Codes: A61F 2002/30883 : dovetail-shaped
• CPC Class Codes: A61F 2002/30892 : parallel
• CPC Class Codes: A61F 2002/30906 : shot- sand- or grit-blasted
• CPC Class Codes: A61F 2002/30925 : etched
• CPC Class Codes: A61F 2002/3093 : for promoting ingrowth of bone tissue
• CPC Class Codes: A61F 2002/30932 : for retarding or preventing ingrowth of bone tissue
• CPC Class Codes: A61F 2002/30952 : using CAD-CAM techniques or NC-techniques
• CPC Class Codes: A61F 2002/3097 : using laser
• CPC Class Codes: A61F 2002/3611 : Heads or epiphyseal parts of femur
• CPC Class Codes: A61F 2002/3625 : Necks
• CPC Class Codes: A61F 2230/0004 : Rounded shapes, e.g. with rounded corners
• CPC Class Codes: A61F 2230/0019 : rectangular
• CPC Class Codes: A61F 2230/0026 : trapezoidal
• CPC Class Codes: A61F 2250/0026 : differing in surface structures
• CPC Class Codes: A61F 2250/0051 : differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2310/00017 : Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 : Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00179 : Ceramics or ceramic-like structures
• CPC Class Codes: A61F 2310/00329 : Glasses, e.g. bioglass
• CPC Class Codes: A61F 2310/00407 : Coating made of titanium or of Ti-based alloys
• CPC Class Codes: A61F 2310/00616 : Coating made of titanium oxide or hydroxides
• CPC Class Codes: A61F 2310/00796 : Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
• CPC Class Codes: A61F 2310/00928 : Coating or prosthesis-covering structure made of glass or of glass-containing compounds, e.g. of bioglass
• CPC Class Codes: A61F 2310/00976 : Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
• CPC Class Codes: A61F 2310/00982 : Coating made of collagen
• CPC Class Codes: A61L 24/04 : containing macromolecular materials
• CPC Class Codes: A61L 2400/18 : Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 2430/00 : Materials or treatment for tissue regeneration
• CPC Class Codes: A61L 2430/12 : for dental implants or prostheses
• CPC Class Codes: A61L 27/38 : containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/50 : Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: B23K 2103/04 : Steel or steel alloys
• CPC Class Codes: B23K 2103/14 : Titanium or alloys thereof
• CPC Class Codes: B23K 26/06 : Shaping the laser beam, e.g. by masks or multi-focusing
• CPC Class Codes: B23K 26/066 : by using masks

Abstract

An implantable substantially planar bioabsorbable article for the separation and regeneration of tissue at a tissue defect site includes first surface of the article, which may be circular or elliptical, that is provided with a soft tissue side intended for direction towards soft or subcutaneous tissue and having a microtextured surface optimized for promotion of ingrowth of soft tissue. An opposite side of the article comprises a different microgrooved surface, optionally including osteoconductive chemical properties, and physically oriented against or within the bone defect site toward and against the center of the defect into which any graft material placed. The membrane is flexible and of sufficient density to accommodate sutures or is circumfentially provided with perforations to hold sutures.

Claims

1. An article for use in healing of wounds and repair of tissue defects, the article comprising:

(a) a flexible membrane having an upper and a lower surface, each surface defining a substrate formed of a biologically-acceptable biodegradable material adapted to be resorbed in use, each substrate having thereon means capable of orienting cell growth comprising a microgeometry formed in said substrates, a microgeometry of said upper surface proportioned to a cell morphology of soft tissue cells and a microgeometry of said lower surface proportioned to a cell morphology of bone tissue cells.

2. The article as recited in claim 1, in which said microgeometry of each substrate comprises a pattern of grooves and ridges.

3. The article as recited in claim 2, in which said ridges comprise posts.

4. The article as recited in claim 1, in which said membrane defines a width of between about 200 and about 500 microns.

5. The article as recited in claim 3, in which said grooves and ridges upon said upper surface defines a dimension of about 2 to about 10 microns, and those upon said lower surface define a dimension of about 8 to about 25 microns.

6. The article as recited in claim 5 in which said biodegradable material is selected from a member of the group consisting of as polylactic acid homopolymers, polyglycollic acid co-polymers, combinations thereof, polylactones, polypeptides, polyvinyl alcohols and natural polymers such as collagen and polysaccharides, collagen, Hench'"'"'s bioglass, fibrinogen and polyimino-carbonate.

7. The article as recited in claim 1, in which a weight of said resorbed material is in a range of one to five grams/cm².

8. The article as recited in claim 3, in which said lower surface includes osteoconductive chemical properties.

9. The article as recited in claim 5, in which said lower surface includes osteoconductive chemical properties.

10. The article as recited in claim 5, in which said membrane comprises means for suturing into or about a wound or bone defect.